Mass spectrometry data acquisition and analysis
Data-independent acquisition improves quantitative cross-linking mass spectrometry
... the data set, for each dilution series we only included residue pairs that were quantifiable across the full set of respective ...SEC data set (121 URPs) to the library, 66 unique residue pairs could be ...
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Statistical analysis of proteomic mass spectrometry data
... in data used for the peak finding method as compared with the complete spectra does not result in much lower correct classification ...same data were analysed by Mian et al. (2005) the data were ...
183
Targeted Data Acquisition for Improved Reproducibility and Robustness of Proteomic Mass Spectrometry Assays
... Quantitative mass spectrometry-based proteomic assays often suffer from a lack of robustness and ...targeted mass spectrometric data acquisition strategy for affinity enriched ...
12
Preprocessing, Management, and Analysis of Mass Spectrometry Proteomics Data
... introducing Mass Spectrometry, we survey different techniques for spectra pre- processing and we present a first design of a software tool that allows to manage efficient storing and preprocessing of ...
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Mass spectrometry based proteomics : data analysis and applications
... In data dependent acquisition (DDA) mode, a preset number of top intense peptides are selected for fragmentation, and an exclusion time period is set to avoid the instrument sampling the high abundant ...
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Computational methods for the analysis of mass spectrometry imaging data
... vi von MSI-Daten vorrangig mithilfe von Visualisierung der Massespeziesverteilung anhand der Ionenintensit¨ atskarten oder mittels Methoden zum Data-Mining durchgef¨ uhrt. Den- noch sind diese herk¨ ommlichen ...
126
Challenges in Computational Analysis of Mass Spectrometry Data for Proteomics
... Keywords mass spectrometry, proteomics, bioinformatics 1 Introduction Proteins play the most important role in disease ...sample. Mass spectrometry is an analytical technique that reveals the ...
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Context-based analysis of mass spectrometry proteomics data
... DIA data [58, 59] due to the ambiguity of m/z values in com- plex peptide ...systematic analysis of fragmentation spectra identified with high confidence by generating and evaluating a model spectral ...
148
Mapping differential interactomes by affinity purification coupled with data independent mass spectrometry acquisition
... unbiased data independent acquisition method, SWATH, and the use of weighted statistics to determine changes and associated confidence ...automatic analysis of the large amounts of data that ...
25
Multimodal FTIR Microscopy-guided Acquisition and Interpretation of MALDI Mass Spectrometry Imaging Data
... restrictive mass feature identification Integration of the molecular information provided by MALDI-MSI and tissue anatomical structures that can be resolved by microscopy is mandatory for its clinical ...FTIR ...
115
Phosphorylation Analysis by Mass Spectrometry
... Refs. 7–9). However, when following their line of argument that the phosphorylated form of a particular peptide should have lower ionization/detection efficiencies than their unmod- ified cognate because both the ...
10
Pesticide Analysis by Mass Spectrometry
... Q12. Why was chrysene-d 12 selected as an internal standard rather than chrysene with a natural isotopic abundance of hydrogen nuclei? Would you expect that the chrysene and chrysene-d 12 to be resolved in the GC ...
11
Drug analysis by mass spectrometry
... Plasma morphine concentrations in four patients with renal failure and in three healthy volunteers were measured using CI QSIM, and morphine pharmacokinetics in th[r] ...
186
Statistical Methods for the Analysis of Mass Spectrometry-based Proteomics Data
... functioning. Mass spectrometry proteomics has become the tool of choice for identifying and quantifying the proteome of an ...a mass spectrometer. The three fundamental challenges in the ...
106
Comprehensive Methods of MALDI-TOF Mass Spectrometry Data Analysis
... Input data-set for classification usually contain several hundreds or even thousands of ...smallest data sub-set chosen with defined criteria among the hole data ...biological data, like ...
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OplAnalyzer: A Toolbox for MALDI-TOF Mass Spectrometry Data Analysis
... Keywords: data analysis, differential analysis, bio-marker discovery, MALDI-TOF, mass spectrometry, OplAnalyzer, ...Introduction Mass spectrometry is an attractive method ...
9
Analysis of Mass Spectrometry data: Significance Analysis of Microarrays for SELDI-MS Data in Proteomics
... expression analysis is likely to become one of the main sources of new biomarkers for personalized medicine, which may include early medical diagnosis, tailoring therapy selection to the prediction of individual ...
8
Quantitative proteomic characterization of human sperm cryopreservation: using data-independent acquisition mass spectrometry
... process, Data-independent acquisition (DIA), a proteomics technology with high quantitative accuracy and high reproducibility was used to quantitatively characterize the proteomics of human sperm ...
9
Data mining in proteomic mass spectrometry
... the mass spec- trum, estimating the average or minimum intensity within the window, and then moving the window across the spectrum to estimate the overall ...
20
MSSimulator: Simulation of Mass Spectrometry Data
... E data, for example, ETISEQ. 21 By providing simulated data, we hope to facilitate algorithm development, as the simulator provides an easy means to benchmark the ...E data is generated by ...
8