metalloproteinase and disintegrin
ADAMTS 1: a metalloproteinase disintegrin essential for normal growth, fertility, and organ morphology and function
... A disintegrin and metalloproteinase (ADAM) represents a protein family possessing both metallo- proteinase and disintegrin domains. ADAMTS-1, an ADAM family member cloned from cachexigenic colon ...
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The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family
... (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and ...
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A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection
... (a disintegrin and metalloproteinase domain) are a family of transmembrane metalloproteinases that play important roles in growth factor and cytokine signaling as well as cell-cell signaling, adhesion, and ...
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The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch mediated signaling
... The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and ...
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A Disintegrin and Metalloproteinase 8 as a Potential Blood Biomarker for Early Diagnosis of Gastric Cancer
... In order to know more detailed role of blood ADAM 8 in carcinogenesis and progression process of GC, we evaluated the correlations between blood levels of ADAM 8 and pre-inflammatory cyt[r] ...
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The role of ADAMTS 1, 4 and 5 in multiple sclerosis
... A disintegrin and metalloproteinase A disintegrin and metalloproteinase with throi Antigen presenting cells Amyloid precursor protein Blood brain barrier Bicinchoninic acid Cell adhesion[r] ...
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Favorable course of previously undiagnosed Methylmalonic Aciduria with Homocystinuria (cblC type) presenting with pulmonary hypertension and aHUS in a young child: a case report
... ADAMTS13: A disintegrin and metalloproteinase with thrombospondin1 motifs (13th member of the family); aHUS: Atypical hemolytic-uremic syn- drome; cblC: cobalamin C; HUS: Hemolytic-uremi[r] ...
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E2 regulates MMP 13 via targeting miR 140 in IL 1β induced extracellular matrix degradation in human chondrocytes
... miRNAs are a class of abundant, small, highly con- served noncoding RNA (approximately 22 nucleotides) found in higher eukaryotes. They act as multifunctional mediators of biological processes by partially base- pairing ...
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Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non bleeding critically ill patients: a prospective substudy of a randomized trial
... a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; APACHE IV score: acute physiology and chronic health evaluation IV score; DIC: disseminated intravascular coagulation; ...
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Kitasato symposium 2010: new prospects for cytokines
... the disintegrin metalloproteinase respon sible for membrane shedding of the IL-6R, may act as a molecular switch between the proinfl ammatory and anti- infl ammatory activities of IL-6 by aff ecting the ...
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Role of eculizumab in a pediatric refractory gemcitabine induced thrombotic microangiopathy: a case report
... After platelet transfusion a sudden dyspnea appeared and, with the suspicion of an allergic reaction, chlor- pheniramine maleate was administered without clinical improvement. A second chest X-ray showed a diffuse ...
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Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction
... Members of the recently identified metalloproteinase family of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) also degrade ECM. However, the relevance of the ADAMTS family to ...
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Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems
... a disintegrin and metalloproteinase domain-containing protein; AICD, APP intracellular domain; Akt, RAC-alpha serine/threonine-protein kinase; AMPAR, AMPA receptor; ApoE, apolipoprotein E; APP, amyloid ...
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Regulation of pregnancy-associated plasma protein A2 (PAPPA2) in a human placental trophoblast cell line (BeWo)
... ADAM12: A disintegrin and metalloproteinase 12; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; HELLP: hemolytic anemia, elevated liver enzymes, and low platelet count; IGF: insulin-lik[r] ...
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Acquired thrombotic thrombocytopenia purpura associated with severe ADAMTS13 deficiency in a 3 year old boy: a case report and review of the literature
... Acquired thrombotic thrombocytopenia purpura (TTP) is very rare in children, and this condition is due to severe deficiency of disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 ...
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Towards extracellular matrix normalization for improved treatment of solid tumors
... matrix metalloproteinase (MMP), a disintegrin and metalloproteinase (ADAM), ADAM with thrombospondin motifs (ADAMTS), cathepsin, plasminogen activator, and b) GAG-degrading enzymes like hyaluronidase ...
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Exosomes from IL 1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes
... a disintegrin and metalloproteinase with thrombospondin motifs; CM: conditioned media; CM-exo: exosome-depleted conditioned media; Cont: control; DMEM: Dulbecco ’ s modified Eagle ’ s medium; EBM-2: ...
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Original Article Impact of gene polymorphisms located near ADAM17 and additional SNP-SNP interaction on ovarian cancer risk in Chinese women
... Received September 27, 2017; Accepted May 3, 2018; Epub September 15, 2018; Published September 30, 2018 Abstract: Objectives: The aim of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) ...
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Sepsis-associated disseminated intravascular coagulation and its differential diagnoses
... DIC disseminated intravascular coagulation, TMA thrombotic microangiopathy, TTP thrombotic thrombocytopenic purpura, ADAMTS13 a disintegrin and metalloproteinase with a thrombospondin ty[r] ...
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Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis
... (a disintegrin and metalloproteinase with thrombospondin motifs; aggrecanase-1) [29], and mono- clonal antibody (MAb) OA-1, specific for the N-terminal ARGS neoepitope generated by aggrecanase cleavage at ...
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