Metastatic progression
Downregulation of Nodal inhibits metastatic progression in retinoblastoma
... receptor, which include Nodal, Activin and growth/dif- ferentiation factor 3 (GDF3), to determine the origin of this pro-metastatic signaling in retinoblastoma cells. The intrinsic serine/threonine kinase activity ...
9
The landscape of metastatic progression patterns across major human cancers
... of metastatic progression across 16 major cancer types in a cohort of 1008 patients with metastatic cancer autopsied between 2000 and 2013 to assess cancer specific progression patterns of ...
14
Epithelial to mesenchymal transition in the metastatic progression of gastroenteropancreatic neuroendocrine tumours
... prolonged progression-free survival in advanced P-NETs for patients on mTOR inhibitor, Everolimus, prompted USA Food and Drug Administration, and Health Canada ...and metastatic status corresponded with ...
130
Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.
... and metastatic spread [14, ...early metastatic divergence have been reported in other tumour types using an analogous phylogenomic approach, where in the case of metachronous lesions, the time between ...
714
Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma
... highly metastatic OS cell lines in a series of in vitro and in vivo experiments, in order to identify a tractable metabolically targeted therapeutic strategy for ...
13
Role of splice variants in the metastatic progression of prostate cancer
... The treatment of localized prostate cancer largely results in excellent survival outcome. In contrast, metastatic prostate cancer is associated with a decreased survival rate of 33% [24]. Metastasis occurs as a ...
5
Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.
... In keeping with previous evidence from large-scale genomic studies [19], targeted sequencing showed clonal mutations in genes accounting for the ‘breakthrough’ and ‘expansion’ phase of the primary CRC [20] such as APC, ...
7
The Role Of Calcineurin/nfat Signaling In Fibroblast Homeostasis And Activation
... and metastatic progression; activated fibroblasts remodel extracellular matrix (ECM) in primary tumor and metastatic microenvironments, exerting both pro- and anti-tumorigenic ...
119
Original Article Development and characterization of experimental models of oligometastatic and polymetastatic progression
... stable metastatic dissemination that presents the window for curative ...of metastatic progression, we report detailed characterization of experimental oligo- and polymetastases ...discrete ...
10
Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion
... with metastatic progression of breast cancer, we examined the expression levels of LKB1 in immortalized breast epithelial cell line MCF-10A and breast cancer cell lines, including luminal A subtype (MCF-7 ...
13
Classification of positive surgical margins and tumor recurrence after nephron-sparing surgery for small renal masses
... There were a total of 600 cases collected for the current survey from four centers, including 20 cases with positive margins on final pathological examination. The average positive margin rate was found to be 3.3%. All ...
8
Clinical outcomes after palbociclib with or without endocrine therapy in postmenopausal women with hormone receptor positive and HER2 negative metastatic breast cancer enrolled in the TREnd trial
... In conclusion, our data suggest that subsequent ther- apies in patients with endocrine resistance who progress on palbociclib do not generally lead to durable re- sponses, with the exception of some long responders who ...
7
Evaluation of Radiation Dose-Response in a Breast Cancer Brain Metastasis Model
... Finally, we evaluated the response of treated and un-treated breast cancer brain metastases with MRI. We showed all the tumors, whether treated or un-treated, grew at least three times over the duration of 11 days. ...
106
Clinical efficacy of nab-paclitaxel in patients with metastatic pancreatic cancer
... with metastatic pancreatic ...with metastatic pancreatic carcinoma between June 2015 and June 2017 at the Medical Oncology Unit of the University Palermo and ARNAS Hospital Civico of ...to ...
7
Haemostatic alterations in a group of canine cancer patients are associated with cancer type and disease progression
... distant metastatic disease had a sig- nificantly elevated d-dimer level and thereby more pro- nounced activation of the coagulation and fibrinolytic systems than patients with local invasive ...distant ...
8
Long-term benefit of sunitinib in patients with metastatic renal cell carcinoma in Latin America: retrospective analysis of patient clinical characteristics
... Twenty-nine patients with long-term clinical benefit from sunitinib were identified between September 2005 and August 2009. Nine patients (the total number of patients treated with sunitinib during this time is not ...
6
Management of hemorrhage in gastrointestinal stromal tumors: a review
... Ten-year progression-free and overall survival in patients with unresectable or metastatic GI stromal tumors: long-term analysis of the European Organisation for Research and Treatment of Cancer, Italian ...
9
Bevacizumab Beyond Progression in Metastatic NSCLC
... 36.4% with a median duration of response of 6 months. When we look to the median follow up duration from the time of initial diagnosis till loss of follow up or death, we find a median duration of 23 months, which can ...
6
Quality of care in urology
... The licensed indication for bicalutamide 150 mg has recently changed in the UK and several other countries. In the UK, bicalutamide 150 mg is indicated as an alternative to castration for patients with locally advanced ...
6
Pathobiology of cancer metastasis: a short account
... Primary cancer cells and their associated reactive stro- mal cells secrete humoral factors including an array of cytokines, chemokines and growth factors which deter- mine tropism for specific distant tissues, and ...
5