Methionine-choline deficient (MCD)
Potential of 99mTc-MIBI SPECT imaging for evaluating non-alcoholic steatohepatitis induced by methionine-choline-deficient diet in mice
... Tc-MIBI scintigraphy is useful for discriminating NASH from simple steatosis in clinical studies [19]. These findings suggest the possibility of 99m Tc-MIBI imaging for the evaluation of hepatic mitochondrial function in ...
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Original Article Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice
... a methionine-choline- deficient (MCD) diet in ...an MCD diet for 30 ...the MCD diet for ≥2 weeks exhibited severe steatohepatitis with elevated serum aspartate aminotransferase ...
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Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis
... a methionine-choline-deficient (MCD) diet, the degree of liver damage is related to dietary sugar content, which drives de novo lipogenesis and promotes the hepatic accumulation of saturated ...
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Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy
... 6; MCD: Methionine/ choline-deficient; MCS: Methionine/choline-supplement; NASH: Non- alcoholic steatohepatitis; NAFLD: Non-alcoholic fatty liver disease; NAS: NAFLD activity ...
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Gene Set Enrichment Analysis (GSEA) of Differentially Expressed Genes in Green Tea against Methionine-Choline Deficient Diet in High-Fat Patients in the Development of Non-Alcoholic Fatty Liver Disease (NAFLD)
... For GEO2R analysis two groups named “2% green tea extract” and “methionine-choline deficient diet” were defined. Four samples were included in the green tea extract group and three constituted the ...
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S100A4 Gene is Crucial for Methionine Choline Deficient Diet Induced Non Alcoholic Fatty Liver Disease in Mice
... with MCD or MCS for 8 weeks, no significant dif- ferences were found in liver function (ALT and AST) and lipid- related parameters (TG and TC) between mice of WT/MCS group and KO/MCS group (all ...in MCD ...
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Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities
... Cholesterol and especially FC is supposed to contribute to hepatocyte death and NASH [38]. FC was normal in the liver of the MCD diet fed mice and CE levels were only higher in WT2 NASH liver. Individual CE ...
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Sensitive and early detection of mitochondrial dysfunction in the liver of NASH model mice by PET imaging with 18F-BCPP-BF
... The methionine-choline- deficient diet (MCD) is one of the most common tools inducing NAFLD in many studies ...of MCD in mice: dramatic weight loss and lack of insulin resistance [22], ...
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AIMS In the present study, we evaluated whether RLX affects the development of liver fibrosis in
... AIMS In the present study, we evaluated whether RLX affects the development of liver fibrosis in an experimental mouse model of NASH in C57BL6 male mice fed with a methionine-choline deficient diet ...
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Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH
... the methionine-choline deficient (MCD) diet rapidly produces the NASH phenotype of hepatic ste- atosis, inflammation, and fibrosis in mice within a short timeframe; however, it does not ...
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Supplementation of Rumen-protected Forms of Methionine, Betaine, and Choline to Early Lactation Holstein Cows
... of methionine, betaine, and choline to a Met-limited corn silage-based total mixed ration (TMR) on microbial metabolism by mixed ruminal ...protected methionine (0.09% of DM as methionine), ...
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Rat model of nonalcoholic steatohepatitis created by methionine and choline deficiency: biochemical and histological analyses
... In conclusion, a model of NASH was created by feed- ing Sprague-Dawley rats an MCD diet for 16 weeks. Histological examination of the liver confirmed the occur- rence of centrilobular fatty change and moderate ...
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Dietary strategies to treat hyperhomocysteinaemia based on the biochemistry of homocysteine: a review
... after methionine loading is lower in black Africans than in Caucasians, which points towards a more effective Hcy ...that methionine handling capacity is ...
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Considering choline as methionine precursor, lipoproteins transporter, hepatic promoter and antioxidant agent in dairy cows
... protected choline supplementation is one of the best steps to export hepatic fat by lipoprotein pathway and improved performance of dairy cows (Zom et ...2013). Choline has significant effects on general ...
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THE EFFECTS OF LIPOTROPIC FACTORS ON PHOSPHOLIPIDE TURNOVER IN THE PLASMA OF PATIENTS WITH CIRRHOSIS OF THE LIVER, AS INDICATED BY RADIOACTIVE PHOSPHORUS
... Group 2: Phospholipide turnover studied before and during treatment wcith a large "test dose" of methionine or choline Table 1I and Figure 2 Eight consecutive patients with portal cirrho[r] ...
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Defining and categorizing outcomes of Moral Case Deliberation (MCD): concept mapping with experienced MCD participants
... on MCD in ...of MCD can be categorized in clusters re- ferring to the personal development (both as an individ- ual as well as a professional, including emotions, skills and knowledge), team development, ...
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Modulatory effect of Kolin PlusTM, a polyherbal formulation on muscle growth development in choline deficient diet model of broilers: a genomic analysis using microarray
... Methods: Microarray was performed for four groups, namely, normal diet (ND) as G1, choline chloride deficient (CCD) diet as G2, choline chloride (CCL, 400 g/ton) as G3 and PHF (400 g/ton) as G4. ...
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COMPARATIVE EFFECTS OF A PURIFIED AND AN ADEQUATE DIET ON THE COURSE OF FATTY CIRRHOSIS IN THE ALCOHOLIC
... Although fatty cirrhosis can be produced in animals by means of low protein diets and prevented by methionine or choline, Eckhardt and his coworkers 7, in a previous study from this labo[r] ...
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A Study on MCD Officials Perception Towards Present Information Sharing Potential in MCD
... make MCD more competitive organization to face global challenges. MCD official are asked to provide their responses through questionnaire about their perceptions regarding various aspects of information ...
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Hepatoprotective and antioxidant activities of extracts from Salvia—Nelumbinis naturalis against nonalcoholic steatohepatitis induced by methionine and choline deficient diet in mice
... Liver damage was exhibited by the elevated serum values of ALT (P <0.01), AST (P <0.01), and TBIL (P <0.001) in the model group compared with the control group. SNN treatment prevented the changes to a certain ...
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