microRNA-206
Original Article Norcantharidin nanocapsules inhibit the invasion and metastasis of esophageal cancer by inhibiting microRNA-206 via IGF1R-PI3K-AKT pathway
... EC109 cells were cultured in RPMI-1640 medi- um (Roswell Park Memorial Institute-1640) (Gibco, Rockville, MD, USA) containing 10% FBS (fetal bovine serum) (Gibco, Rockville, MD, USA) and maintained in a 5% CO 2 incubator ...
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microRNA-1/133a and microRNA-206/133b clusters: Dysregulation and functional roles in human cancers
... that microRNA-1 (miR-1), microRNA-133a (miR-133a), microRNA- 133b (miR-133b) and microRNA-206 (miR-206) are frequently downregulated in various types of ...
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Original Article Decreased serum microRNA-206 level predicts unfavorable prognosis in patients with melanoma
... Abstract: Background and purpose: MicroRNA-206 (miR-206) acts as a tumor suppressor in melanoma cell lines. However, its clinical significance remains unclear. The aim of this study was to detect the ...
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Original Article Transient downregulation of microRNA-206 protects alkali burn injury in mouse cornea by regulating connexin 43
... of microRNA 206 (miR-206) in relieving chemical burn in mouse ...miR- 206 down-regulation in alkali-burned cornea. Conclusion: miR-206, associated with Cx43, is a novel molecular ...
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MicroRNA-206: a Promising Theranostic Marker
... miRNA/miR: microRNA; mRNA: messenger RNA; DGCR8: DiGeorge syndrome critical region 8; UTR: untranslated region; Ago: Argounat; hsa: homo sapiens; HMGB1: high mobility group box 1 protein; IL: interleukin; TF: ...
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Original Article Propofol ameliorates ischemia/reperfusion induced cerebral injury by upregulation of microRNA-206 expression
... rching we found that Otx2 is a potential target of miR-206. The transcription factor OTX2, a member of the OTX family that is characterized by the presence of a conserved 60-amino acid residue homeodomain, binds ...
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microRNA-206 is involved in survival of hypoxia preconditioned mesenchymal stem cells through targeting Pim-1 kinase
... The miR-206 oligonucleotides including mimics, inhibitors, and negative control were purchased from GenePharma Co., Ltd (Shanghai, China). We dissolved the oligonu- cleotides with diethylpyrocarbonate ...
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microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13
... produced higher levels of cleaved p25, indicating induction of apoptosis in both MB231 and HepG2 cells (Figure 3D). Moreover, each of these cell lines produced slower growing tumors following subcutaneous injection into ...
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Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation
... physiology [35]. Accordingly, alterations in the expression of target genes could lead to disease states. MET proto- oncogene is located on chromosome 7q21–31 and encodes the receptor tyrosine kinase MET. In several ...
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<p>MicroRNA-206 inhibits metastasis of triple-negative breast cancer by targeting transmembrane 4 L6 family member 1</p>
... Transmembrane 4 L-six family member 1 (TM4SF1) is a small plasma membrane glycoprotein that belongs to the transmembrane 4 superfamily, also known as the tetraspa- nin family. 6 TM4SF1 plays important roles in the ...
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microRNA 206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice
... microRNAs (miRNAs) are a class of small noncoding RNAs that inhibit gene expression via Watson-Crick base pairing between the miRNA “seed” region and sequences located predominantly in the 3′ UTRs of target mRNAs (20). ...
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Overexpression of microRNA 206 in the skeletal muscle from myotonic dystrophy type 1 patients
... Hypothetical mRNA targets of miR-206 can also be derived, trough computational analysis, from microarray studies of mRNA differentially expressed in DM1 tissues. Osborne at al. [8] performed a global mRNA ...
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MicroRNA 206 Reduces Osteosarcoma Cell Malignancy In Vitro by Targeting the PAX3 MET Axis
... Western blot evaluating the protein expression levels of the cell proliferation marker protein PCNA revealed that OS cell pro- liferation was significantly reduced by miR-206 overexpres- sion and increased by ...
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MicroRNA-206 suppresses gastric cancer cell growth and metastasis
... online microRNA tar- get acquisition tools, and cross-referenced the resulting candidates to those that have been reported to play a role in ...P2GM-miR- 206 stable cells compared to their respective levels ...
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Original Article MiR-206 regulates the proliferation and metastasis of HCC cells via targeting E2F5
... Abstract: Background: MicroRNA-206 (miR-206) has been identified as a tumor suppressor in many cancers. How- ever, the molecular biological function in HCC has not been elucidated. The aim of this ...
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MiR-206, a Key Modulator of Skeletal Muscle Development and Disease
... fibers of the mouse model of ALS. There, miR-206 as a key regulator of bidirectional signaling between skel- etal muscle fibers and nerves, miR-206 is capable of sensing damage or loss of motor neurons and ...
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Original Article Down-regulation of microRNA-126 and microRNA-133b acts as novel predictor biomarkers in progression and metastasis of non small cell lung cancer
... of microRNA-126 (miR-126) and microRNA-133b (miR-133b) and also their association with clinicopatho- logical features in patients with non small cell lung cancer ...
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miR 206 regulates the growth of the teleost tilapia (Oreochromis niloticus) through the modulation of IGF 1 gene expression
... miR- 206 inhibition by antagomir treatment resulted in a significant reduction in miR-206 expression, but a significant increase in IGF- 1 expression in tilapia ...
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Differences in microRNA expression between melanoma and healthy adjacent skin
... One mechanism through which cancer cells promote disease progression is alteration oftheir miRNA expres- sion profile. MicroRNAs are small non-coding RNAs playing a key rolein post-transcriptional gene regulation in ...
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Identifying MicroRNA Precursors Using Linear Dimensionality Reduction With Explicit Feature Mapping
... the microRNA family, lin-4 and 14, were originally identified in Caenorhabditis elegans as genes that were necessary for temporal regulation of larval development ...discovering microRNA functions and its ...
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