MicroRNA-27a
MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2
... MicroRNAs (miRNAs) are a class of small non-coding, endogenous, single-stranded RNAs of 18–23 nucleotides in length, which regulate gene expression by promoting mRNA degradation or inhibiting translation by binding to ...
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Original Article MicroRNA-27a adjusts diabetic nephropathy patients and inhibits TGF-β/Smad signaling pathway
... of microRNA- 27a suppressed apoptosis and caspase-3 activity,reduced TGFβ1 and p-Smad2 protein expression in diabetic ...study, microRNA-27a down-regulation suppressed FN, Col-IV, and α-SMA ...
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Original Article MicroRNA-27a-3p promotes the metastasis and epithelial-mesenchymal transition of gastric cancer via targeting RUNX1
... Abstract: Increasing evidence shows that microRNAs (miRNAs) are a novel class of gene regulators, and play a vital role in tumor development and progression. MicroRNA-27a (miR-27a) was previously ...
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Original Article MicroRNA-27a restrains the immune response to mycobacterium tuberculosis infection by targeting IRAK4, a promoter of the NF-κB pathway
... Abstract: This study aimed to explore the influence of microRNA-27a on immune response to mycobacterium tuber- culosis (Mtb) and the molecular mechanism. MiRNA-27a was screened one of the ...
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MicroRNA-27a promotes renal tubulointerstitial fibrosis via suppressing PPARγ pathway in diabetic nephropathy
... MicroRNA-27a (miR-27a) upregulation has been identified in diabetes, but the pathogenesis of miR-27a in renal tubulointerstitial fibrosis (TIF) in diabetic nephropathy (DN) has not been ...
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MicroRNA-27a Regulates Lipid Metabolism and Inhibits Hepatitis C Virus Replication in Human Hepatoma Cells
... Functional relevance of the upregulated miRNAs in HCV-in- fected livers. Previously, 19 miRNAs were shown to be differen- tially expressed in HBV- and HCV-infected livers (2). Of these, 6 miRNAs were upregulated and 13 ...
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Original Article MicroRNA-27a acts as a novel biomarker in the diagnosis of patients with laryngeal squamous cell carcinoma
... Abstract: Background: Increased evidences suggest that the microRNA-23a/24-2/27a (miR-23a/24-2/27a) cluster may play a crucial role in carcinogenesis and act as a novel oncogene. Among these members, ...
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<p>MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma</p>
... To our knowledge, this is the fi rst comprehensive report concerning the role of miR-27a in radiosensitivity in ESCC by modulating Hsp90 expression. In general, miRNAs mod- ulate the gene expression through base ...
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Coordinated Targeting of the EGFR Signaling Axis by MicroRNA- 27a*
... Epidermal growth factor receptor (EGFR) has been characterized as a critical factor in the development and progression of multiple solid tumors, including head and neck squamous cell carcinoma (HNSCC). However, ...
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<p>MicroRNA-27a-3p Reverses Adriamycin Resistance by Targeting BTG2 and Activating PI3K/Akt Pathway in Breast Cancer Cells</p>
... Overall, these results suggest that miR-27a-3p activates the PI3K/Akt signaling pathway by targeting BTG2 in MCF- 7/ADR cells. These early fi ndings may provide a starting point in developing a promising ...
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RETRACTED ARTICLE: Down-regulation of microRNA-26a and up-regulation of microRNA-27a contributes to aggressive progression of human osteosarcoma
... In the present study, the results indicated that patients with high expression of miR-27a had shorter overall sur- vival than those with low miRNAs expression. Moreover, Multivariate Cox proportional hazards model ...
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Reduced Expression of miRNA-27a Modulates Cisplatin Resistance in Bladder Cancer by Targeting the Cystine/Glutamate Exchanger SLC7A11
... in microRNA expression during the development of cisplatin resistance in various cancer lines including those derived from hepatocellular carcinoma (27), ovarian cancer (28), non-small cell lung cancer (29), and ...
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MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2
... microRNA-27a (miR-27a) is frequently dysregulated in human carcinoma, including gastric cancer. The B-cell translocation gene 2 (BTG2) has been implicated in gastric carcinogenesis. However, till ...
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Original Article Downregulation of miR-27a-3p may increase hematoma volume in rats with intracerebral hemorrhage
... chased rats were rigorously screened. Gender, age (weeks), body weight, indoor temperature, and indoor humidity had no effect on the results, thereby ensuring the scientific rigor of this study. In this study, the ...
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A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression
... an miR-27a binding site in its 3’UTR (Figure 5C), as well as PPAR-γ (Figure 5D), a transcriptional activator potentially leading to an enhanced M2 phenotype in the presence of an appropriate M2 stimulus such as ...
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Obesity-associated miR-27a upregulation promotes hepatocellular carcinoma metastasis through suppressing SFRP1
... tissue-secreted miR-27a is upregulated in obese liver cancer tissues. Next, we established the co-culture system of 3T3-L1 cells transfected with a miR-27a overexpress plasmid with HepG2 cells in vitro and ...
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Identifying MicroRNA Precursors Using Linear Dimensionality Reduction With Explicit Feature Mapping
... The authors obtained a total number of 2,241 pre-microRNAs from miRBase 8.2. They used 200 human pre-microRNAs and 400 randomly selected pseudo hairpins for training and finding parameters of miPred and called it TR-H. ...
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miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)
... Damaged mitochondria are selectively tagged by a combin- ation of PINK1 and Parkin and then, delivered to lysosome for hydrolytic degradation [11]. Therefore, we next exam- ined whether miR-27a/b inhibit the ...
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Original Article Down-regulation of microRNA-126 and microRNA-133b acts as novel predictor biomarkers in progression and metastasis of non small cell lung cancer
... of microRNA-126 (miR-126) and microRNA-133b (miR-133b) and also their association with clinicopatho- logical features in patients with non small cell lung cancer ...
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Differences in microRNA expression between melanoma and healthy adjacent skin
... To confirm the microarray results, total RNA previously isolated from melanoma and healthy adjacent skin samples wasused to estimate the expression levels of miR-363-3p and miR-3591. These microRNAs were ...
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