microtubule stability
The Hsp70 and Hsp40 Chaperones Influence Microtubule Stability in Chlamydomonas
... in microtubule stability might involve a client protein that affects the dynamics of microtubules, either by direct interaction with microtubules or through an indirect mecha- ...promote microtubule ...
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RPM 1 regulates axon termination by affecting growth cone collapse and microtubule stability
... for microtubule stability, we examined axonal ...reduced microtubule stability causes axonal swellings in ALM mechanosensory neurons (Topalidou et ...a microtubule destabilizer, and ...
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Dendrites differ from axons in patterns of microtubule stability and polymerization during development
... with microtubule ends ...in microtubule acetylation or dety- rosination could bias kinesin-mediated transport to par- ticular neurites, generating positive feedback signaling to allow for continued ...
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The direct and indirect effects of α-synuclein on microtubule stability in the pathogenesis of Parkinson’s disease
... effecting microtubule dynamics has been investigated as a potential source of ...on microtubule stability. Directly, it may act as a microtubule-associated protein, binding to microtubules and ...
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Saccharomyces cerevisiae PAC2 Functions With CIN1, 2 and 4 in a Pathway Leading to Normal Microtubule Stability
... The products of the Saccharomyces cerevisiae CINl, CIN2 and CIN4 genes participate in a nonessential pathway required for normal microtubule function.. In this article, we d[r] ...
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Cell Cycle Regulators Interact with Pathways That Modulate Microtubule Stability in Saccharomyces cerevisiae
... of FCP1 overexpression, only the swi6-S160A allele is able to suppress the temperature sensitivity of our mutants (Fig. 4B). The fact that rescue of the temperature sensitivity in the absence of FCP1 overexpression ...
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The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye
... mutation causes an amino acid substitution (G382R) within the Sac phosphatase domain, six amino acids upstream of the catalytic motif (Fig. 1B). To determine whether the G382R (TS) mutation affects Sac1 protein ...
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Dosage Suppressors of a Benomyl-Dependent Tubulin Mutant: Evidence for a Link Between Microtubule Stability and Cellular Metabolism
... However, we not only found that a cbfl mutation did not suppress tub2- 150, but also that neitherJYN1 nor JSN2 required CBFZ for suppression (the situation for JSN3is compl[r] ...
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Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachment
... [26–28]. Microtubule stability is associated with greater re-attachment of suspended tumor cells to endothelial monolayers and lung trapping in a murine experimental metastasis model [17, 19, 20, ...
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Basnet, Nirakar (2020): Investigation of self-assembling machinery in cell shape formation. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... 2011). Microtubule minus end directed motor protein dynein selectively transports the cargoes in dendrites (Kapitein et ...with microtubule stabilizing agent taxol shows that there is also some ...
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Chlamydia Hijacks ARF GTPases To Coordinate Microtubule Posttranslational Modifications and Golgi Complex Positioning
... The PTM of tubulin is a consequence of MT stability (41). Interestingly, the loss of CT813, ARF1, and ARF4 profoundly affects the PTM of MT cages present around the inclusion (Fig. 2), indicating that these ...
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Lesions in Many Different Spindle Components Activate the Spindle Checkpoint in the Budding Yeast Saccharomyces cerevisiae
... point: Microtubule motors move along the surface of microtubules, and genetic and cell biological experi- ments have implicated motors in many aspects of mitosis and meiosis in a wide variety of ...of ...
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Neukirchen, Dorothee (2010): CLIPs regulate neuronal polarization through microtubule and growth cone dynamics. Dissertation, LMU München: Fakultät für Biologie
... the microtubule cytoskeleton could be part of this proposed positive feedback loop in the future ...local microtubule stabilization (Witte et ...or microtubule cytoskeleton is sufficient to promote ...
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Regulation of cell migration by dynamic microtubules
... of microtubule-associated proteins relate to their function in regulating microtubule ...persistent microtubule growth in the cytoplasm [75], and APC stabilises microtubules by promoting growth, ...
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Phosphorylation of The Tau Protein in Neurodegenerative Disease
... affect microtubule affinity, cell localization, or the overall function of specific MAPs with a profound effect on neuronal ...The microtubule-binding activity of a MAP is regulated by the phosphorylation ...
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Development of dendrite polarity in Drosophila neurons
... However, the dendrites in which microtubules have been studied most extensively in vivo do not have mixed polarity. Drosophila neurons have axons and dendrites with polarized structure and function similar to mam- malian ...
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Disruption of CEP290 microtubule/membrane binding domains causes retinal degeneration
... responsible for mediating these specific functions. The N terminus of the protein, containing a highly conserved amphipathic helix, mediates CEP290’s membrane-binding activity. Such helices have previously been shown to ...
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Different motilities of microtubules driven by kinesin-1 and kinesin-14 motors patterned on nanopillars
... a microtubule (34); unlike kinesin-14, kinesin-1 is known as a processive ...two microtubule binding domains (MTBDs): The first MTBD, which is referred to as the motor domain, is at the C terminus, and the ...
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Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes
... the microtubule inhibitor nocodazole and the histone deacetylase inhibitor Trichostatin A inhibit markedly the aggresome formation in cells expressing Tks4 R43W ...the microtubule system to the ...
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In vitro wound healing of tumor cells: inhibition of cell migration by selected cytotoxic alkaloids
... the microtubule-stabilizer paclitaxel (a diterpene alkaloid from Taxus that clinically used in the treatment of Kaposi’s sarcoma, lung, ovarian and breast cancer) and the microtubule-destabilizer ...
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