minimal residual
<p>Monitoring of Minimal Residual Disease (MRD) in Chronic Myeloid Leukemia: Recent Advances</p>
... To determine alternative biomarkers to discriminate which patients can safely and successfully discontinue imatinib use, miRNAs expression quanti fi cation has also been con- sidered. Using a TaqMan miRNA array on PB ...
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<p>Strategies for minimal residual disease detection: current perspectives</p>
... Despite the significance of MRD in acute leukemia having been widely explored, with an increasing number of studies demonstrating the positive prognostic value of MRD nega- tivity, the assessment of molecular ...
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The relation between end of induction minimal residual disease and different risk factors in patients with acute lymphoblastic leukemia
... Materials and Methods: This analytic-descriptive study consisted of 91 patients with ALL who referred to Seyed Alshohada Hospital, Isfahan, Iran. The mean age of the patients was 4.91 3.07 years old. The patients were ...
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Brentuximab Vedotin Monotherapy and Combined with Low Dose Donor Lymphocyte Infusion to Control Minimal Residual Disease and Sustain Clinical Remission in a Child with Relapsed Anaplastic Large Cell Lymphoma
... Minimal residual disease (MRD) appears to have a strong negative predictive value for disease recurrence in children with anaplastic large cell lymphoma ...
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A comparison of flow cytometry detection of minimal residual disease and chimerism kinetics in chronic lymphocytic leukemia patients after allogeneic hematopoietic stem cell transplantation
... quality of response, provided by novel agents and new therapeutic approaches, requires necessarily more sensi- tive tools for precise remission assessment [2-7]. The evaluation of response to treatment in CLL is ...
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Automated analysis of acute myeloid leukemia minimal residual disease using a support vector machine
... of minimal residual disease (MRD) using real-time quantitative polymerase chain reaction (RQ-PCR) and flow cytometry (FCM) provide a powerful basis for adjusting the diagnosis and treatment ...
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Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia
... when the ITD is located in the tyrosine kinase domain [3,4]. The internal tandem duplications in FLT3 interferes with the auto-inhibitory function of the juxtamembrane domaine and constitutively activates the tyrosine ...
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Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia
... MRD: Minimal residual disease; CR: Complete remission; FCM: Flow cytometry; RT-PCR: Real-time polymerase chain reaction; TCR: T-cell receptor; Ig: Immunoglobulin; LMW: Low-molecular-weight; SELDI-TOF-MS: ...
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Evaluation of Minimal Residual Disease in Acute Myeloid Leukemia with NPM1 Marker
... NPM1 mutation is more specific, sensitive and stable molecular marker in comparison with the above mentioned markers. 7 After induction therapy, complete remission rate in AML with normal karyotype (AML-NK) patients with ...
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Impact of obesity on breast cancer recurrence and minimal residual disease
... of residual tumor cells that survive and persist following tumor regression suggests a novel hypothesis to explain the biological mechanisms by which obesity might result in accelerated tumor ...
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Studying the Concept of Minimal Residual Disease Detection in Cases of CLL
... The present work aimed at detecting MRD in CLL specimens using a combination of four antibodies (CD5/19/20/79b) and a sequential gating strategy to effectively separate CLL cells from normal B cells. In the present ...
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A QMR Type Algorithm for Drazin Inverse Solution of Singular Nonsymmetric Linear Systems
... Drazin-Quasi-minimal residual algorithm (DQMR here- after) is another implementation of the projection method for singular linear systems is analogues to Lanczos algorithm for non-singular ...
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Impact of obinutuzumab alone and in combination for follicular lymphoma
... Abstract: Although rituximab-based chemoimmunotherapy prolongs the survival of patients with follicular lymphoma (FL), this disease is considered incurable in most patients. Thus, new therapies are needed not only for ...
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Expressions and bounds for the GMREs residual
... the minimal residual norm is large as long as the Krylov basis is ...the minimal residual norm is expressed in terms of eigenvalues and departure from ...the minimal residual ...
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Profile of blinatumomab and its potential in the treatment of relapsed/refractory acute lymphoblastic leukemia
... transiently engage cytotoxic T-cells to CD19+ target B-cells inducing serial perforin-mediated lysis. In the first clinical trial, blinatumomab showed efficacy in non-Hodgkin’s lymphomas, but the most important trials ...
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Long Term Survival in a Patient with Anaplastic Thyroid Carcinoma Treated with Cricotracheal Resection
... with minimal residual disease, that then under- went chemotherapy and radiation compared to those un- dergoing palliative resection or chemotherapy and radia- tion without ...
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Impact of blinatumomab on patient outcomes in relapsed/refractory acute lymphoblastic leukemia: evidence to date
... Abstract: Relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) is associated with a poor prognosis in both children and adults. Traditionally, there were limited options for salvage therapy, which consisted ...
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Using the new INTRABEAM mobile intraoperative radiotherapy system during surgery for pancreatic cancer: a case report
... cancer, with the goal of pain reduction and control of locoregional tumor progression [7, 8]. Formerly, IORT was performed with an electron energy source emit- ting a 6–20 MeV high-powered electron beam [9]: this ...
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Approximation by Splines of Hermite Type
... where the second factor on the right-hand side is the determinant of a block-matrix of order m + 2. Using this assertion, we get the representation of residual of approximation by minimal splines of ...
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Incorporating robotic surgery into the management of ovarian cancer after neoadjuvant chemotherapy
... During this latter period, the decision to proceed with robotic surgery rather than laparotomy was made by the gynecologic oncology tumor board following an initial assessment of whether complete cytoreduction could be ...
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