Minimal Residual Disease
Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse
... Minimal residual disease before and after transplantation Due to the extraordinary genetic heterogeneity of AML, it is difficult to set up general recommendations for mo- lecular monitoring of ...
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Clinical Significance of Minimal Residual Disease at the End of Remission Induction Therapy in Childhood Acute Lymphoblastic Leukemia
... Minimal residual disease (MRD) is defined as the presence of sub-microscopic levels of leukaemic cells. [1] Detection of MRD during remission induction and consolidation therapy is the most sensitive ...
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Downregulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: a possible biomarker to discontinue imatinib safely
... Notes: a distinct expression pattern was found in the STOP-IM group (middle lane). Using SDS (version 2.4) and DataAssist software (Thermo Fisher), we calculated the expression of mirnas based on their ct values ...
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Automated analysis of acute myeloid leukemia minimal residual disease using a support vector machine
... analyze minimal residual disease (MRD) in flow cytometry data from patients with acute myeloid leukemia (AML) automatically, objectively and ...initial disease data and MRD review data in the ...
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Minimal residual disease- and graft-vs.-host disease-guided multiple consolidation chemotherapy and donor lymphocyte infusion prevent second acute leukemia relapse after allotransplant
... In persons receiving an allotransplant for acute leukemia, we reported an association between a positive minimal residual disease (MRD)-test after transplant and an increased risk of subsequent ...
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<p>Monitoring of Minimal Residual Disease (MRD) in Chronic Myeloid Leukemia: Recent Advances</p>
... To determine alternative biomarkers to discriminate which patients can safely and successfully discontinue imatinib use, miRNAs expression quanti fi cation has also been con- sidered. Using a TaqMan miRNA array on PB ...
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The prognostic significance of minimal residual disease in adult Egyptian patients with precursor acute lymphoblastic leukemia
... for Minimal residual disease (MRD) detection were developed for detection of lower frequencies of malignant cells during and after treatment ...
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Evaluation of Relationship between Minimal Residual Disease (MRD) and Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) Using Quantitative Fluorescent PCR
... 13. Cave H., van der Werff ten Bosch J., Suciu S., Guidal C., Waterkeyn C., Otten J., Bakkus M., Thielemans K., Grandchamp B., and Vilmer E. Clinical significance of minimal residual disease in ...
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Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia
... MRD: Minimal residual disease; CR: Complete remission; FCM: Flow cytometry; RT-PCR: Real-time polymerase chain reaction; TCR: T-cell receptor; Ig: Immunoglobulin; LMW: Low-molecular-weight; ...
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Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia
... when the ITD is located in the tyrosine kinase domain [3,4]. The internal tandem duplications in FLT3 interferes with the auto-inhibitory function of the juxtamembrane domaine and constitutively activates the tyrosine ...
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Clinical significance of minimal residual disease in adult acute lymphoblastic leukemia
... between minimal residual disease and outcome in adult acute lymphoblastic leukemia. Detection of[r] ...
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Comparison between qualitative and real-time polymerase chain reaction to evaluate minimal residual disease in children with acute lymphoblastic leukemia
... Introduction: Minimal residual disease is an important independent prognostic factor that can identify poor responders among patients with acute lymphoblastic ...analyze minimal ...
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The relation between end of induction minimal residual disease and different risk factors in patients with acute lymphoblastic leukemia
... the minimal residual disease, can be satisfactory (10-12), where the advanced treatment for increasing survival of children with cancers, especially those with ALL is very important ...in ...
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Comparison between Three Promising ß-emitting Radionuclides, 67Cu, 47Sc and 161Tb, with Emphasis on Doses Delivered to Minimal Residual Disease
... eradicate minimal residual disease [2, ...the disease [4,6,38,39], probably because the distribution of the radiopharmaceutical in tumors is still relatively ...
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Potential biomarkers for adult acute myeloid leukemia minimal residual disease assessment searched by serum peptidome profiling
... MRD: Minimal residual disease; MB-WCX: Weak cation exchange magnetic beads; MALDI-TOF-MS: Matrix assisted laser desorption ionization time of flight mass spectrometry; AML: Acute myeloid leukemia; ...
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Feasibility of Treating Post-Transplantation Minimal Residual Disease in Children with Acute Leukemia
... post-transplantation minimal residual disease (MRD) are ...post-HCT disease restaging evaluation, 31 patients (78%) presented with overt disease at the time of ...rapid disease ...
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Papadaki, Christina (2017): Detection of minimal residual disease in Acute Myeloid Leukemia with t(8;21) translocation. Dissertation, LMU München: Medizinische Fakultät
... heterogeneous disease, as reflected by differences in the morphology of the leukemic blasts and by variations in the clinical picture and therapeutic ...of residual malignant cells surviving after ...of ...
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Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study
... Patients with a poor treatment response by morphologic criteria have a high risk of relapse [11,12]. But morpho- logic studies will only identify a minority of those chil- dren with ALL who eventually fail. ...
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Evaluation of Minimal Residual Disease in Acute Myeloid Leukemia with NPM1 Marker
... 8 Minimal residual disease (MRD) tests provide early identification of hematologic relapse and timely management of acute myeloid leukemia (AML) ...
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IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia
... included minimal residual disease (MRD) analysis and required two MRD targets with sensitivities of # 1 3 10 24 ...had residual disease of $ 5 3 10 24 on treatment day ...
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