minor-groove
Shape selective recognition of the DNA minor groove by hairpin polyamides
... of minor groove-binding polyamides as tools for genomic analysis and expansion of the minor groove recognition code by designing internal and N-terminal replacements for ...
18
Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups
... this minor groove binder rather than any intrinsic property of the ...Nevertheless, minor groove binders with both nitroalkenyl (11a,c) and tri- fl uoroacetamido (14c) tail groups showed signi ...
9
Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A
... CD analysis of each ODN in PIPES buffer indicated a typical B- type DNA tertiary structure: a negative peak at 255 nm and a large positive peak at 285 nm consistent with other short oligonucleotides (Fig. 8). Ligand ...
12
Sequence-selective minor groove recognition of a DNA duplex containing synthetic genetic components
... a minor groove “ G mimic ” via the formation of a hydrogen bond with the endocyclic N3 atom of Im4/Im8 in ...enlarged minor groove width of DNA7 Figure ...(c) Minor and (d) major ...
9
Synthesis of New Series of Bis Benzothiazole Derivatives as DNA Minor Groove Binding Agents
... A series of novel bis-benzothiazole derivaties with head-to head orientation were synthesised, and their anti- proliferative activities on U937, HL60 and HeLa cells were investigated. Most of these new compounds showed ...
6
Four pyrrole derivatives used as building blocks in the synthesis of minor groove binders
... of minor-groove binders (MGBs) has expanded vastly and now these compounds display a wide spectrum of biological activities, such as anti- bacterial, antifungal, antiparasitic and anticancer ...the ...
24
Superresolution imaging of single DNA molecules using stochastic photoblinking of minor groove and intercalating dyes
... and minor groove binders, which attach between the helical ...the minor groove binders, such as SYTO-13, have been less well studied despite being potentially less perturbative to the DNA ...
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A simplified duplex real time PCR incorporating TaqMan minor groove binder (MGB) probes and an exogenous internal positive control for the simultaneous detection of Mycoplasma gallisepticum and Mycoplasma synoviae cultures
... labelled minor groove binder (MGB) probes that target the cytadhesin encoding surface protein (mgc2) gene and the haemagglutinin surface protein (vlhA) gene of MG and MS, ...
6
Establishment of a minor groove binder probe based quantitative real time PCR to detect Borrelia burgdorferi sensu lato and differentiation of Borrelia spielmanii by osp A specific conventional PCR
... TaqMan™ minor groove binder (MGB)- probe has an advantage over a conventional TaqMan™ probe regarding mismatch discrimination [22] and the use of a non-fluorescent quencher (NFQ) results in more precise ...
10
2D-IR spectroscopy shows that optimised DNA minor groove binding of Hoechst33258 follows an induced fit model
... Here, we show that the distinct difference between H33258 binding to A-tract and alternating sequence DNA is the loss of the ordered propeller twist arrangement of the base pairs present in the uncomplexed A-tract. This ...
24
Synthesis a novel DNA minor groove binding agents by bis benzimidazole
... Bis-benzimidazoles have been proved to be potent anti-tumor agents via DNA minor groove binding, such as Hoechst 33258(Scheme 1). Hoechst 33258[1], a fluorescent compound with a head-to-tail ...
5
Why antibacterial minor groove binders are a good thing
... processes associated with cell wall integrity and energy production are affected. Attempts to generate resistant strains have failed. Taken together, these properties identify Strathclyde minor groove ...
21
Ranking ligand affinity for the DNA minor groove by experiment and simulation
... Analysis of the 1 H NMR data for the complex between 1 and 5´-CGACTAGTCG-3´ (Figure 1a) had already established that minor groove binding occurs with a staggered 2:1, head-to-tail, side-by-side binding ...
13
An evaluation of minor groove binders as anti-lung cancer therapeutics
... major groove; however, with the minor groove binding affinity conferred by the distamycin framework, tallimustine has been shown to preferentially monoalkylate the 3’-adenine-N3 atom of 5’-TTTTGA-3’ ...
11
Racial Disparity in Social Spatiality: Usage of National Parks and Opera Attendance
... DNA minor groove, the ligand curvature has been considered as one of the important factors along with hydrogen-bonding and hydrophobic interactions ...the minor groove to yield full contact ...
193
Constructing Empirical Likelihood Confidence Intervals for Medical Cost Data with Censored Observations
... the minor groove of ATGA is illustrated in Figure ...the minor groove to act as a hydrogen bond acceptor with the amino group of G (Figure ...the minor groove while the attached ...
218
Ethyl 2 aminooxazole 5 carboxylate
... Ethyl 2-aminooxazole-5-carboxylate, (I), was prepared as part of an ongoing investigation of anticancer antibiotic drugs such as distamycin and netropsin (lexitropsins; see Khalaf et al., 2000). Since these drugs exhibit ...
7
Positive Impact Program Evaluation
... Minor groove DNA binding compounds hold great potential for new drugs, not only as anti-parasitics, but also as human genome regulators that can target other ...Other minor groove binding ...
114
Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders
... of minor-groove binders (MGBs) has expanded vastly and now these compounds display a wide spectrum of biological activities, such as anti- bacterial, antifungal, antiparasitic and anticancer ...the ...
25
ATP-Dependent Minor Groove Recognition of TA Base Pairs Is Required for Template Melting by the E1 Initiator Protein
... The requirement for multiple TA bp is related to binding of multiple E1 molecules. Proximal and distal T-dependent melt- ing, which in combination accounts for most of the melting that we observe on the wt template, is ...
10