Minor groove binding ligand
Ranking ligand affinity for the DNA minor groove by experiment and simulation
... the ligand have subtle effects on ...on binding and the reasons for the differences and established a computational method to rank ligand affinity against varying DNA ...
13
Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A
... targeting ligand through hydrogen bond formation is enthalpically favourable and assists complex ...of binding processes to be built ...to binding may not be evident if it is offset by greater ...
12
Comparative effects of A.T and G.C sequence selective DNA minor groove binding agents
... strong ligand binding sequences determined in this earlier study was ...the ligand is bound. At the site where binding does not occur, no inhibition was ...which ligand binding ...
227
DNA minor groove binders-inspired by nature
... panel shows DNase I cleavage patterns of Sequence A in the presence of thiazotropsin B. Ligand concentrations 169 (µM) are shown at the top of each gel lane. GA corresponds to marker lanes specific for purines, ...
33
Protein and drug interactions in the minor groove of DNA
... B-DNA minor groove have been analyzed in crystal structures of 60 protein–DNA and 14 drug–DNA ...simultaneous binding to N3 and N2 in guanines is extremely ...acid ligand, are stereochemically ...
10
Interaction of DNA with groove binding ligands
... cooperative binding to homeodomain DNA binding proteins is due to conformational changes in the DNA that are induced by the binding of the first ligand 75 ...drug binding event, or by ...
235
2D-IR spectroscopy shows that optimised DNA minor groove binding of Hoechst33258 follows an induced fit model
... to ligand binding in itself, the disruption of the A- tract structure leads to a closer interaction between ligand and DNA than is possible in the alternating ...that binding to A-tract DNA is ...
24
CiteSeerX — Simultaneous Binding of Minor Groove Binder and Intercalator to Dodecamer DNA: Importance of Relative Orientation of Donor and Acceptor
... bound ligand molecules in genomic ...for minor groove binding in the genomic ...simultaneous binding of ligands is to use a smaller DNA as the host for both of the ...and minor ...
6
Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove
... DNA minor groove carries with it the advantage that a comparison can be drawn between the assembled structure of AIK-18/51 in both free and DNA bound ...of binding. Global rearrangement of a dimer ...
37
Antiparallel Side-by-Side Heterodimer for Sequence-Specific Recognition in the Minor Groove of DNA by a Distamycin/
... of binding mixed sequences with high specificities, the 2:1 models accurately predicted binding to a 5'-(A,T)G(A,T)3- 3' sequence by the D/2-ImN ...each ligand is targeted to a single strand of the ...
5
Synthesis a novel DNA minor groove binding agents by bis benzimidazole
... _____________________________________________________________________________________________ ABSTRACT A new series of bis-benzimidazole derivatives was designed and synthesized. In vitro cytotoxity evaluation showed ...
5
Synthesis of New Series of Bis Benzothiazole Derivatives as DNA Minor Groove Binding Agents
... 2 The 716 th Institute of CSIC, P. R. China ___________________________________________________________________________________ ABSTRACT A series of novel bis-benzothiazole derivaties with head-to head orientation were ...
6
Selectivity in anti-infective minor groove binders
... Abstract: Minor groove binders for DNA synthesised at the University of Strathclyde (S-MGBs) have been successfully shown to be active against a wide range of infectious organisms including bacteria, fungi, ...
18
Molecular pharmacology of a series of nitrogen mustard containing-and AT- and GC- recognising minor groove binding agents related to distamycin
... covalent binding affinity. A higher non-covalent binding affinity m ay not ex p lain the fact th at tw o occurrences of 5 -TTTTAA are only w eakly alk y lated or m issed, how ...non-covalent binding ...
230
Impact of pyrrolidine-bispyrrole DNA minor groove binding agents and chirality on global proteomic profile in Escherichia Coli
... target minor grooves of duplex DNA for controlling specific gene expression implicated in a ...of minor groove binders on DNA interaction, especially at the protein expression ...DNA binding ...
9
Why antibacterial minor groove binders are a good thing
... Med. Chem. Commun., 2013, 4, 1105-1108), which showed that a head-to-tail dimer was especially stable in aqueous solution; this dimer is believed to bind to DNA intact leading to exceptionally tight binding ...
21
Minor groove binders: some recent research in drug development
... the minor groove of DNA at regions with four or five AT base pairs, ...DNA binding molecules, one of which is the treatment of MRSA, hospital acquired infections caused by Staphylococcus aureus and ...
11
An evaluation of minor groove binders as anti-lung cancer therapeutics
... Keywords: Minor Groove Binders; Anti-cancer; Lung Cancer Cancer is a major health problem responsible for approximately 13 % of the deaths ...major groove of the DNA where the drug interferes with ...
11
Minor groove binders for DNA as antitypanosomal agents : the veterinary context
... The metabolomics observations can be compared with the results from RNA-seq experiments using another S-MGB (3) attacking Staphylococcus aureus (see paper ‘Why antibacterial minor groove binders are a good ...
19
Shape selective recognition of the DNA minor groove by hairpin polyamides
... of minor groove-binding polyamides as tools for genomic analysis and expansion of the minor groove recognition code by designing internal and N-terminal replacements for ...
18