MiRNA binding
Bioinformatics approach prediction of nonsynonymous and miRNA-binding site polymorphisms within human SclA9 and Scl22A12 genes
... in miRNA-binding sites not only offer a possibility of novel diagnostic in Gout disease, but can also help to understand complex regulatory networks of miRNAs in health and ...
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Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs
... putative miRNA binding sites affected whether or not a tran- script would be enriched in the pull-down, we fitted a logistic regression model for enrichment status, includ- ing the counts of each type of ...
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MicroRNA-related polymorphisms in apoptosis pathway genes are predictive of clinical outcome in patients with limited disease small cell lung cancer
... affecting miRNA binding to targets in the apoptosis pathway on clinical outcome in ...explore miRNA-related SNPs associated with prognosis in SCLC, we did not recruit enough cases for independent ...
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Partition function and base pairing probabilities of RNA heterodimers
... the binding energy, almost completely destroy the functionality of the binding ...that miRNA binding sites are not functional because of the GU base pairs, testing the dimer with RNAcofold ...
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The inhibition of microRNAs by HIV 1 Tat suppresses beta catenin activity in astrocytes
... HIV‑1 Tat binds to a specific subset of cellular microRNAs Previous studies have shown that Tat interacts with Dicer only in the presence of RNA [33]. Here, we exam- ined which miRNAs are capable of binding to Tat ...
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The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA 122
... RNA is bound and activated by mutant miR122p3+4 (11). As endogenous miR-122 does not regulate this reporter, we were able to measure basal translation in the absence of miRNA binding, and found that LSm1 ...
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Single-nucleotide polymorphism in microRNA-binding site of <em>SULF1</em> target gene as a protective factor against the susceptibility to breast cancer: a case-control study
... the miRNA-binding sites within the 3′-UTR of SULF1 may serve as protective factors against the susceptibility to breast cancer, especially to ER-positive breast cancer in the Chinese ...susceptibility, ...
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Weinmann, Lasse (2009): Functional characterisation of microRNA-containing Argonaute protein complexes. Dissertation, LMU München: Fakultät für Biologie
... mRNA binding proteins that specifically co- immunpoprecipitate with Ago1 and Ago2 in an RNA-dependent manner, suggesting that miRNPs may act in concert with these mRNA binding proteins to achieve repression ...
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The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes
... putative miRNA-binding sites ...the binding sites for miR-584 and miR-744 but the minor allele is pre- dicted to alter the DDG for either miRNA by ,1 kJ/mol (Supplemen- tary Table II is ...
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Potential roles of microRNAs in regulating long intergenic noncoding RNAs
... (4) MiRNA binding sites were predicted on lincRNA sequences derived from transcript ...predicted miRNA sites were evaluated on the pairs showed a significant reverse correlation on their expression ...
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Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data
... from miRNA overexpression [3, 25, ...the miRNA overex- pression strategy, as it is often challenging to distinguish direct miRNA targets from indirect targets ...under miRNA overexpression in ...
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Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
... illegitimate miRNA binding sites could contri- bute significantly to risk for neurodegenerative ...increased binding of miR-659 to the 3 ’ UTR of the progranulin (GRN) gene provides an important risk ...
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Introns targeted by plant microRNAs: a possible novel mechanism of gene regulation
... predicted miRNA—intron ...likely miRNA—intron interactions. During the first step, the predicted miRNA binding sites along with the 50-nt surrounding sequences at both ends were col- ...a ...
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MicroRNAs control mRNA fate by compartmentalization based on 3′ UTR length in male germ cells
... by binding the 3 ′ UTRs of their target transcripts, it remains interesting to study the relationship between miRNAs and ...to miRNA-binding sites (Additional file 1: Figure S8), supporting the ...
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<p>The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer</p>
... multiple miRNA binding sites, indicating that these EV-carried circRNAs may function as competing endogen- ous RNAs in receipt cells after uptaking EVs from cancer ...
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PubMedCentral-PMC4958391.pdf
... The BRIP1 (BRCA1-interacting protein 1), which belongs to the DEAH helicase family [23, 24], is an essential tumor suppressor gene. It has been demonstrated that BRIP1-encoded helicase could interact with BRCA2, playing ...
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A scoring matrix approach to detecting miRNA target sites
... An input alignment of n sequences allows construction of n - 1 leave one out alignments (we did not leave out the reverse complement of the miRNA), so data sets contain- ing more experimentally validated target ...
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Accelerating MicroRNA Target Prediction Using Multithreading
... the miRNA targets with lower false-positive ...between miRNA and mRNA sequences eases the prediction of miRNA targets in ...between miRNA and mRNA lacks the perfect ...validated ...
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MicroRNA-mediated regulation of target genes in several brain regions is correlated to both microRNA-targeting-specific promoter methylation and differential microRNA expression
... between miRNA-mediated gene regulation, miRNA-targeting-specific promoter methylation, and differential miRNA expression, also considering both sample gen- der and age (see ...the miRNA ...
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Polymorphisms at microRNA binding sites of Ara C and anthracyclines metabolic pathway genes are associated with outcome of acute myeloid leukemia patients
... Ara‑C: cytarabine; poly‑miRTS: polymorphisms at microRNA‑binding sites; AML: acute myeloid leukemia; SNPs: single nucleotide polymorphisms; CR: complete remission; OS: overall survival; RFS: relapse‑free survival; ...
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