miRNA target
miRNA-target network reveals miR-124as a key miRNA contributing to clear cell renal cell carcinoma aggressive behaviour by targeting CAV1 and FLOT1
... Two hundred nanograms of total RNA were labelled using Illumina TotalPrep-96 RNA Amplification kit (PN:4393543, Ambion Life Technologies, Grand Island, NY, USA) as per amplification protocol. 750ng of cRNA were generated ...
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Systematic analysis of dynamic miRNA target interactions during C elegans development
... of miRNA::target interactions within the group (FDR ...weak miRNA regulation at all stages ...Drosophila miRNA ‘anti-targets’, which generally have short 3 ⬘ UTRs and low densities of ...
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mirMark: a site level and UTR level classifier for miRNA target prediction
... for miRNA target prediction, based on different ...and target-site abundance ...the target site ...discover miRNA and mRNA correlations by incorporating large amounts of experimental ...
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A scoring matrix approach to detecting miRNA target sites
... Several miRNA target prediction systems have imple- mented post-processing steps in order to increase their ...of target sites. Here target sites that appear not to be conserved between mul- ...
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The miR159-GAMYB pathway: silencing and function of GAMYB homologues amongst diverse plant species
... example, target-site accessibility can influence miRNA-target recognition and has been incorporated in bioinformatic prediction programs of miRNA targets in animals (Figure ...decrease ...
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Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data
... of miRNA target prediction, available prediction algorithms still have sub- optimal performance, leading to frequent false predic- tions that are experimentally costly at the validation ...computational ...
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Original Article Potential gene and microRNA biomarkers for pancreatic cancer with gene expression analysis
... CRTK7 [34, 35]. Meanwhile, STAT1 was also up- regulated by hsa-miR-145. Wu et al. have found that activation of the STAT1 pathway may play an important role in the increased reactive oxy- gen species production which ...
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RETRACTED ARTICLE: Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR-127 in human bladder cancer
... exploring miRNA-target interactions from CLIP-Seq (HITS-CLIP, PAR-CLIP) and degradome sequencing (PARE) data ...multiple target predictions, such as TargetScan, PicTar, miRanda, PITA, RNA22 and ...
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Original Article Down-regulation of microRNA-20a in gemcitabine-resistant pancreatic cancer in in vitro microRNA integrative analysis
... With miRNA microarray, we identi- fied a total of 34 miRNAs that were abnormally expressed in BxPC-3/Gem ...of miRNA target genes, we identified that has-mir-20a, which has a highest-degree node, as ...
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Weinmann, Lasse (2009): Functional characterisation of microRNA-containing Argonaute protein complexes. Dissertation, LMU München: Fakultät für Biologie
... several miRNA targets, although its interaction with Ago proteins is ...to miRNA target mRNAs prior to miRNP ...the target mRNAs or to stabilize the interaction of Ago proteins with ...
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Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One Carbon Metabolism Genes
... predicted miRNA targeting of OCM genes, we first identified all common HapMap Phase III and dbSNP v131 single nucleotide polymorphisms (SNPs with minor allele frequency ...predicted miRNA target ...
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MicroRNAs in Rice Innate Immunity
... the miRNA/miRNA* sequence within a miRNA precursor (transgene) with a sequence designed to match the target ...the miRNA- based technology for plant genetic engineering is the ...
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MmPalateMiRNA, an R package compendium illustrating analysis of miRNA microarray data
... two-color miRNA experiment using available packages from Bio- conductor and the Comprehensive R Archive Network ...ing, miRNA target identification, and gene set enrichment ...of miRNA analysis ...
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Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting in Caenorhabditis elegans Somatic Tissues
... a miRNA target (purple asterisk in Figure 5B) is present and used in the long 39UTR isoform, and therefore acts as a translation reporter (Figure ...
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Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs
... inferred miRNA target sets and those de- duced from the other studies were significantly greater than expected by chance (Table S3 in Additional file 1; FET, P -values from ...miR-17-5p miRNA duplex, ...
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Recent progress in microRNA-based delivery systems for the treatment of human disease
... targets miRNA-122; it is conjugated to a multivalent N-acetylgalactosamine carbohydrate structure that was de- signed to enhance uptake via binding to the asialoglycopro- tein receptor on ...liposome-encapsulated ...
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Micro RNA Mimics And Antagonists
... of miRNA, feedback based on miRNA levels and activity remain ...including miRNA remains a mystery at present. Evolution of miRNA and overall inhibitory RNA machinery also remain largely ...
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MicroRNA Detection Using a Double Molecular Beacon Approach: Distinguishing Between miRNA and Pre-miRNA
... of miRNA vary depending on species, tissue, cell type and disease state with ranges from nanomolar to fetamolar concentrations ...quantitate miRNA, including northern blotting, qRT-PCR, miRNA ...
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Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA
... Four samples were excluded due to low quality. A group of 47 carcinoids tumors were analyzed; each with paired tumor-adjacent normal tissue samples (at least 5 cm away from the primary tumors). There are 24 pairs of ...
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The potential role of miRNAs in therapy of breast and ovarian cancers associated with BRCA1 mutation
... how miRNA-638 influenced sensi- tivity to UV-light and cisplatin in triple- negative breast cancer ...that miRNA-638 regulates BRCA1 ...of miRNA-638 can lead to an increased susceptibility of TNBC ...
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