Mitochondria/metabolism
Interaction between peroxisomes and mitochondria in fatty acid metabolism
... and mitochondria are ubiquitously found ...mitochondrial metabolism is closely related to energy production, peroxisome does not seem to be associated with energy production but with the pro- duction of ...
7
Mitochondria and lipid metabolism in mammalian oocytes and early embryos
... Pyruvate is the primary metabolic substrate used by mouse and human oocyte mitochondria, and may also be important in zygotic genome activation (Nagaraj et al., 2017). However, it is provided at a rather low ...
12
Glutathione influence on energy metabolism in rat liver mitochondria under experimental nephropathy
... The introduction of glutathione showed that it induced to increase the content of sulfhydryl groups (Fig. 4) at third day (17%) and seventh day (2%) compared to groups of animals with nephropathy. We supposed that ...
6
In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity
... adaptations (Asmann et al. 2006; Carrasco-Pozo et al. 2012; Davis et al. 2009; Henagan et al. 2014; Rayamajhi et al. 2013; Sparks et al. 2005; Stewart et al. 2008). Spe- cifically, previous studies revealed that elevated ...
12
Regulation of Renal Citrate Metabolism by Bicarbonate Ion and pH: Observations in Tissue Slices and Mitochondria
... The effect of acid-base balance on the oxidation and utilization of citrate and other organic acids has been studied in tissue slices and isolated kidney mitochondria. The results show that: 1) With ...
15
Impact of a Disruption of a Pathway Delivering Copper to Mitochondria on Podospora anserina Metabolism and Life Span
... Cu/Zn SOD activities document the availability of copper in the cytoplasm of the PaCox17::ble strains. The aim of the present study was to construct a P. anserina strain in which copper depletion is restricted to the ...
12
Connecting lysosomes and mitochondria – a novel role for lipid metabolism in cancer cell death
... the mitochondria fuel flex test to investigate which source the cells mainly use for beta oxi- ...the mitochondria by using the specific inhibitors BPTES, which inhibits conversion of glutamine to ...
16
Mitochondria, cholesterol and cancer cell metabolism
... altered metabolism by redirecting glucose and glutamine to the production of ribose-5-phosphate for nucleotide synthesis and to the regeneration of NADPH through the activation of the pentose-phosphate pathway ...
24
Metformin directly acts on mitochondria to alter cellular bioenergetics
... chondrial metabolism (Figure ...mitochondrial metabolism in cells treated with metformin compared with untreated ...mitochondrial metabolism are more metabolically responsive to ...the ...
14
The role of mitochondria in aging
... The exact reasons why we age are poorly understood. Aging is thought to be a degenerative process caused by accumulated dam- age that leads to cellular dysfunction, tissue failure, and death. A number of aging theories ...
8
Mitochondria in lung disease
... interactions. Mitochondria form a dynam- ic interconnected intracellular network, changing cellular location via cytoskeletal motors and altering size and shape in response to the metabolic needs of the ...cell. ...
13
Skeletal Muscle Lipid Metabolism and Markers of Insulin Resistance in Young Male Low Birth Weight Offspring in Combination With a Postnatal Western Diet
... Defects along this oxidative pathway have the potential to allow for accumulation of acylcarnitine metabolites, which have recently emerged as strong indicators of mitochondrial dysfunction and increased nutrient load. ...
197
Review of the adaptation of skeletal muscle in intermittent claudication
... muscle metabolism include hyperplasia, proliferation, ballooning of the cristae and paracrystalline inclusions in skeletal muscle mitochon- ...the mitochondria are deemed to be the cause of the energy ...
14
STAMPing into Mitochondria
... Figure 2. STAMP2 links inflammation and metabolism. STAMP2 integrates nutrient, hormone and inflammatory signals with metabolic pathways. FFA/feeding stimuli and inflammatory signals (cytokines)/adipokines (TNF-α, ...
6
Mitochondria as signaling organelles
... between mitochondria and the rest of the cell under physiological ...lular metabolism and tumor necrosis factor receptor sig- naling ...to mitochondria, the redox state of the different electron ...
7
Platelet aerobic metabolism: new perspectives
... We have recently shown that platelets display a consistent oxygen consumption and ATP production in the presence of NADH, a respiring substrate not suitable for mitochondria in vitro. This NADH-stimulated oxygen ...
8
Abstract: microRNAs can cause male infertility by impacting sperm
... litter rate in four mating combinations, we suggested that miR-125b-2 knockout could affect the female and male mouse reproduction performances. In this study, it was validated that miR-125b-2 had a greater influence on ...
36
Mitochondrial fidelity and metabolic agility control immune cell fate and function
... in mitochondrial homeostasis (122). Briefly, the mitochondrial regulatory functions of these deacetylases can be exemplified by (a) SIRT1 contribution to nuclear regulatory control of mitochon- drial biogenesis and to ...
12
A radical shift in perspective: mitochondria as regulators of reactive oxygen species
... energy metabolism-linked mitochondrial redox signals may be indirectly mediated via the influence of H 2 O 2 on glutathione (GSH) status – the ratio of GSH ...
11
Tumor metabolism regulating chemosensitivity in ovarian cancer
... bound to the outer mitochondrial membrane (OMM), and localized within mitochondria [33]. Both HKI and HKII are inhibited by G-6-P, its catalytic product via feedback inhibition [13]. HKII, a predominant isoform in ...
21