mitochondrial translocation
Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway
... and mitochondrial translocation of cofilin, based on the following evidence: (i) AITC inhibited PI3K activity and Akt activation in dose- and time-dependent manners; (ii) Pretreatment with PI3K inhibitor ...
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Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
... erucin-mediated mitochondrial fission during ...of mitochondrial fission [26, ...mediates mitochondrial fission ...the mitochondrial tubule ...and mitochondrial fission is strongly ...
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Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y CELLS
... that mitochondrial p53 can induce apoptosis independent of its transcriptional activity [27, 28] and that induction of apoptosis is one of the major mechanistic targets for chemotherapeutic agents, especially ...
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Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC
... the mitochondrial translocation of EGFR; further, it leads to mitochondrial fission and redistribution in the lamellipodia, upregulates cellular ATP production, and enhances motility in vitro and in ...
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Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway
... Our results demonstrate that activation of ROCK1 has a critical role in the regulation of Akt inactivation, JNK activation, cofilin dephosphorylation and mitochondrial translocation, and mitochondrial ...
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Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition
... p53 translocation into mitochondria in response to oxidative stress remains ...of mitochondrial permeability transition, cyclosporine A (CsA) was able to effectively reduce GOX mediated mi- tochondrial p53 ...
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Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53
... p53 mitochondrial translocation was diminished (Figure ...promoted mitochondrial translocation of p53 in Caco-2 (p53-null) cells transfected with ...that mitochondrial ...
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ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine
... of mitochondrial fission, and its recruitment to mitochon- dria is tightly regulated by posttranslational modifica- tions such as phosphorylation, S-nitrosylation, SUMOylation, and ubiquitination ...Drp1-dependent ...
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Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death
... Chemoresistance in cancer has previously been attributed to gene mutations or deficiency. Caspase mutations or Bax deficiency can lead to resistance to cancer drugs. We recently demonstrated that Bak initiates a ...
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Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK
... membrane translocation of p47; mitochondrial translocation of cleaved cleaved form of protein kinase C delta type (PKCδ); mitochondrial membrane potential; intramitochondrial Ca 2+ level; ROS ...
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Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight
... of hTERT expression by low‑dose cisplatin contributes to chemo‑ therapy resistance in human hepatocellular cancer cells.. Role of mitochondrial translocation of telomer‑ ase in hepatocel[r] ...
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How translocation affects the activity, home range and pair-bonds of great spotted kiwi (Apteryx haastii)
... There was no immediate difference between pre and post translocation for either set of birds. This result is interesting because it was hypothesized that the activity would likely increase post ...
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Applying structured decision making to management of the reintroduced hihi population in Bushy Park :|ba thesis presented for the degree of Master of Science in Conservation Biology at Massey University, Palmerston North, New Zealand
... The need of this decision was triggered by Bushy Park Trust application for additional translocation of 15 females in order to reinforce the population. The Hihi Recovery Group developed four fundamental ...
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Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1
... consistent with the finding that the Bim/Mcl-1 complex is critical for apoptosis modulation in chronic lymphocytic leukemia [41, 42]. Moreover, following ATF2 depletion, Bim was no longer released from the Mcl-1/Bim ...
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Requirements for Carnitine Shuttle Mediated Translocation of Mitochondrial Acetyl Moieties to the Yeast Cytosol
... the mitochondrial carnitine shuttle can directly link acetyl-CoA synthesis via the mitochon- drial PDH complex, the predominant source of acetyl-CoA in aerobic, glucose-grown ...
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7. Evaluation of nickel phytoremediation potential of Rumex dentatus: a greenhouse experiment
... factor, translocation factor and bioaccumulation coefficient Bioconcentration factor (BCF), translocation factor (TF) and bioaccumulation coefficient (BAC) of the Rumex dentatus grown in control and ...
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“Mitochondrial remodeling” in coronary heart disease
... for mitochondrial fusion and ...of mitochondrial fusion. Mfn1 and Mfn2 locate in the outer mitochondrial membrane with their GTPase site facing the cytosol to coordinate the fusion process with the ...
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Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons
... in mitochondrial morphology further sup- port that mitochondrial health is likely to be affected in VCP mutant iPSC-derived ...mal mitochondrial morphology has been witnessed in other VCP mutant ...
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A NEW TECHNIQUE FOR THE PRODUCTION OF AB TRANSLOCATIONS AND THEIR USE IN GENETIC ANALYSIS
... Any gene proximal to the break point of the reciprocal A translocation in the chromosome not involved in the original A-B translocation (Figure 1, region 3) will[r] ...
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Uncertainties in assessing tillage erosion – How appropriate are our measuring techniques?
... the translocation calculation, which is based on fluorescence intensity ...lower translocation distances determined by the stone-sized RFID macro-tracers compared to soil-sized micro-tracers (Table ...
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