mitogen-activated ERK kinase
Regulation of Human Immunodeficiency Virus Type 1 Infectivity by the ERK Mitogen-Activated Protein Kinase Signaling Pathway
... ERK2 mitogen-activated protein kinases (MAPK) play a critical role in regulation of cell pro- liferation and differentiation in response to mitogens and other extracellular ...tively activated Ras, ...
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PKM2, function and expression and regulation
... protein kinase, which forms a complex with β-catenin and binds to the CCND1 promoter region to phosphorylate histone H3, and phosphorylated histone H3 is separated from histone deacetylase 3, which will make the ...
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Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice
... of MKP-3 does not influence the extent of acute mechanical allodynia (postoperative day 1). Nonetheless, lack of MKP-3 influences the transition from acute to chronic postoperative hypersensitivity. These data indicate ...
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Regulation of the mitogen activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts
... inactive kinase to the nuclear compartment (Mizukami and Yoshida, ...was activated in response to reperfusion, suggesting an interface capable of ERK activation in the nuclear ...display ERK ...
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Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis like systemic inflammatory response in mice
... and mitogen-activated protein kinases (MAPKs) [extracellular related kinase (ERK) and c-jun-NH2 terminal kinase (JNK)], the production of cytokines [tumor necrosis alpha (TNFa), ...
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Enhanced expression of microtubule-associated protein 7 functioned as a contributor to cervical cancer cell migration and is predictive of adverse prognosis
... of mitogen‑activated protein kinase kinase (MEK) and extracellular signal‑regulated kinase (ERK) in Caski and HeLa cells, and overexpression of MAP7 increased their ...
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ERK-MAPK Signaling Opposes Rho-Kinase to Reduce Cardiomyocyte Apoptosis in Heart Ischemic Preconditioning
... signal–regulated kinase (ERK) 1/2 activity and reduced Rho-kinase activity and cardiomyocyte apoptosis (P < ...of ERK–mitogen-activated protein kinase (MAPK), increased ...
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Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis
... transition; eRK, mitogen-activated protein kinase; G-CSF, granulocyte colony-stimulating-factor; HGF, hepatocyte growth factor; HiF-α, hypoxia-inducible factor; HNSCC, Head and Neck Squamous ...
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A Review of the Molecular Pathways of Oncogenic HPV and Targeted the Rapies in Carcinoma of the Uterine Cervix
... d. ERK/Mitogen Activated Protein Kinase (MAPK) pathway also known as RAF/MEK pathway lies downstream of several growth factors such as Epidermal Growth Factor (EGF) which when activated ...
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The ERK Mitogen-Activated Protein Kinase Pathway Contributes to Ebola Virus Glycoprotein-Induced Cytotoxicity
... the ERK/MAPK signaling cascade, and it is likely that downstream substrates of ERK2 mediate GP ...Once activated, the ubiquitously expressed ERK1 and ERK2 MAPKs modify a diverse array of substrates that ...
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Role of the stress activated protein kinases in endothelin induced cardiomyocyte hypertrophy
... of mitogen-activated protein (MAP) ki- nases or another stress-response MAP kinase, p38, by over- expression of activated mutants of various components of the pathways is sufficient to induce ...
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Pseudorabies Virus Tegument Protein Us2 Recruits the Mitogen-Activated Protein Kinase Extracellular-Regulated Kinase (ERK) to Membranes through Interaction with the ERK Common Docking Domain
... in panel A fused to the Gal4 DBD were cotransformed with a Gal4 AD ERK2 expression plasmid into yeast. Transformants were plated on medium lacking leucine, tryptophan, and histidine (medium stringency). (C) ...
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Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts
... phosphorylated mitogen-activated protein kinases (MAPKs: ERK 1 /ERK 2 ), protein kinase B (Akt), nuclear factor kappa- light-chain-enhancer of activated B cells (NF- κ B), ...
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Selective activation of the mitogen activated protein kinase subgroups c Jun NH2 terminal kinase and p38 by IL 1 and TNF in human articular chondrocytes
... tyrosine kinase inhibitors pre- vented the expression of most IL-1 b inducible proteins in hu- man articular ...nases ERK-1 (44 kD) and ERK-2 (42 ...to ERK showed that chon- drocytes express ...
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“Docking Studies on Eupalitin-3-O-β-D-galactopyranoside as Potential Inhibitor of Cyprinus carpio (KOI CARP) MAPK/ERK Kinase 2 and Mitogen-Activated Protein Kinase (p38)” by Kader Asen Fathima, Chetancherry Somasundaram Parameswari, India.
... MEK1. Val211 and Leu215 form van der Waals interactions with the C-ring of Quercetin. The hydroxyl group at the 3′ position of the C-ring can make a critical hydrogen bond with the backbone amide group of Ser212. These ...
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Heparin Inhibits Proliferation and Migration of Patient-Derived Vascular Cells Only at Non-physiological Concentrations Due to Antagonistic Pathways
... Cold trypsin phosphorylation specific flow cytometry was used to study the response of the MAPK-ERK pathway to varying concentrations of heparin (Fig. 7A) [32-34]. Patient-derived VSMCs were grown in 6-well ...
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Kinase Activity Profiling of Gram-Negative Pneumonia
... pp38–mitogen- activated protein kinase (pp38-MAPK), pp42/44-MAPK, pSMAD1/5/8, pSRC and pGSK-3β (Cell Signaling Technol- ogy, Boston, MA, USA) and β-actin (Santa Cruz Biotechnology, Santa Cruz, CA, ...
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Response of Mammalian Macrophages to Challenge with the Chlorovirus Acanthocystis turfacea Chlorella Virus 1
... Virus infections that persist in and stimulate inflammatory factors in macrophages contribute to pathologies in humans. A pre- vious study showed that DNA sequences homologous to the chlorovirus ATCV-1 were found in a ...
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Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin
... stimulate ERK signaling in PC-12 cells [30], and SORLA-deficient mice showing enhanced APP cleavage to sAPP and Ab display increased neurogenesis and ERK signaling in hippocampal neurons ...
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Molecular responses to abiotic stress and the development of drought tolerance in plants
... A gene encoding a mitogenactivated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, c[r] ...
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