(mouse) androgen receptor
Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages
... immunohistochemistry. Androgen receptor mRNA was detected in hearts from ...in mouse heart at early postnatal development. Androgen receptor expression is similar in males and females ...
6
LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models
... the androgen receptor response element (ARE) in HEK293 cells co-transfected with peAR-Wt and peAR- V7 plasmids and with a renilla luciferase vector used as a transfection efficiency control as previously ...
9
Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions
... the androgen receptor (AR) are one of the causes of defective ...mutant receptor had any androgen-binding ...mutant receptor had a consistently (approximately 50%) reduced capacity to ...
10
Androgen Receptor as a Driver of Therapeutic Resistance in Advanced Prostate Cancer
... the androgen receptor (AR) signaling axis in the progression of prostate cancer is a cornerstone to our understanding of the molecular mechanisms causing castration-resistant prostate cancer ...ago, ...
8
Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization
... of androgen treatment on both muscle mass and strength ...nuclear androgen receptor (AR), a member of the nuclear receptor super-family ...in receptor function lead to multiple ...
12
Correlation of androgen receptor expression in epithelial and Stromal cells of prostatic carcnoma with tumor grade
... Androgen control over normal growth of the prostate is transmitted via Androgen receptor (AR) that is expressed by the nuclei of both stromal and epithelial cells (Sar et al., 1990). mechanisms ...
5
Substitution of arginine 839 by cysteine or histidine in the androgen receptor causes different receptor phenotypes in cultured cells and coordinate degrees of clinical androgen resistance
... the androgen receptor gene with receptor phenotypes and with clinical phenotypes of androgen ...Their androgen receptor mutation changed arginine-839 to ...normal ...
10
Urinary Oxalate Excretion Decreased in Androgen Receptor Knockout Mice by Suppressing Oxalate Synthesis in the Liver
... All mice were fed a standard commercial diet (Rodent Diet CE-2; CLEA Japan, Tokyo, Japan) and given dis- tilled water. At 14 weeks of age, five AR L−/Y and five AR L+/Y mice were weighed, and administered 0.5% ethy- lene ...
10
Targeting Androgen Receptor Action for Prostate Cancer Treatment: Does the Post-Receptor Level Provide Novel Opportunities?
... an androgen-responsive gene is accepted often to in- dicate functional involvement of AR-recruiting re- gions in regulation of gene expression ...and androgen-regulated genes identified ...to ...
12
ARA55 in Cancers: A Double-Edged Sword
... from mouse MC3T3 osteoblasts induced by TGF β1 and H 2 O 2 ...glucocorticoid receptor coactivation and interacting with multiple proteins such as Androgen Receptor (AR), Cysteine-Rich Protein ...
5
1 Importance of the androgen receptor signalling in
... the expression levels increase progressively until pubertal onset, when all Sertoli cells express the.. 69.[r] ...
20
An imaging agent to detect androgen receptor and its active splice variants in prostate cancer
... Iodination improves the potency of EPI-002 in functional assays. Iodination of EPI-002 (I-EPI-002) could potentially alter many of the properties of the parent compound EPI-002, such as potency, biological activ- ity, ...
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The Ongoing Challenges of Targeting the Androgen Receptor.
... Huggins in 1941 [Huggins 1941]. Even in the castration resistant setting, the cancer remains androgen driven in most patients [Ang 2009], a concept that has been unequivocally proven by the clinical success of ...
8
The influence of sex hormones on cardiac and skeletal muscle function in the MDX mouse model of Duchenne Muscular Dystrophy
... GLOSSARY OF ABBREVIATIONS AAV adeno-associated virus ACE angiotensin converting enzyme AO antisense oligonucleotide AR androgen receptor BW body weight C57 C57BL/10ScSn mouse Ca 2+ calci[r] ...
18
Localisation du récepteur des androgènes dans le testicule
... : Immunohistechemical localization of androgen receptor in mouse testicular germ cells during fetal and postnatal development.. Key Words : testis, germ cells, androgen recepto[r] ...
12
Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer
... with androgen dep- rivation therapy (ADT), including chemical or surgical castration, which decreases the tumor size and serum prostate-specific antigen (PSA) level ...[21]. Androgen receptor vari- ...
10
Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... The androgen receptor (AR) is a key transcription factor in the initiation and progression of prostate cancer (PC) and is a major therapeutic target for the treatment of advanced ...elevated receptor ...
13
Recent advances on the progressive mechanism and therapy in castration-resistant prostate cancer
... tumoral androgen is related to the tumor microenvironment to a certain ...through androgen receptor (AR) activation in CRPC cells, could also be enhanced by prostate stromal ...
12
NGF Induces Proliferation and Aggressiveness in Prostate Cancer Cells.
... androgen receptor and nerve growth factor receptor in prostate cancer cells: implications for a new. 725[r] ...
24
Evaluation of denaturing gradient gel electrophoresis (DGGE) as a method of mutation detection
... Single base mutation in the human androgen receptor gene causing complete androgen insensitivity: Rapid detection by a modified denaturing gradient gel electrophores[r] ...
207