Mre11-Nbs1-Rad50 complex
hSSB1 rapidly binds at the sites of DNA double strand breaks and is required for the efficient recruitment of the MRN complex
... MRN complex is thought to be the sensor and initiator of the DSB response pathway, and activates ATM and downstream DSB signalling, by tethering broken DNA ends together and recruiting ATM which facilitates ATM ...
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A Novel Recombination Pathway Initiated by the Mre11/Rad50/Nbs1 Complex Eliminates Palindromes During Meiosis in Schizosaccharomyces pombe
... served Mre11/Rad50/Nbs1 (MRN) complex is likely directly involved in processing palindromes through the homologous recombination pathway of DNA ...MRN complex for full activity and ...
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Serotype-Specific Reorganization of the Mre11 Complex by Adenoviral E4orf3 Proteins
... cellular Mre11 complex and is prevented by both the E4orf3 and E4orf6 ...The Mre11/Rad50/Nbs1 proteins are targeted for proteasome-mediated degradation by the Ad5 viral E1b55K/E4orf6 ...
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Relocalization of the Mre11-Rad50-Nbs1 Complex by the Adenovirus E4 ORF3 Protein Is Required for Viral Replication
... for Mre11 (ATLD1) or Nbs1 (GM07166) where the E4 ORF3/ORF6 double mutants grew nearly as well as the parent virus dl355 ( ⬃ 2-fold average ...functional Mre11 or Nbs1 rescued the growth defect ...
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Ataxia-telangiectasia Mutated Kinase (ATM) as a Central Regulator of Radiation-induced DNA Damage Response
... protein complex is re- quired for its activation – MRN complex consisting of Mre11, Rad50, and Nbs1 protein ...MRN complex and that mu- tation of its components leads to genetic ...
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Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe
... the Mre11-Rad50-Nbs1 (MRN) complex has known roles in repair processes like homologous recombination and microhomology-mediated end-joining, its role in nonhomologous end-joining (NHEJ) is ...
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Adenovirus Regulates Sumoylation of Mre11-Rad50-Nbs1 Components through a Paralog-Specific Mechanism
... of Nbs1 and SUMO-2 conjugation of ...MRN complex is degraded through a Ub-protea- some pathway during Ad infection ...MRN complex is also a substrate of sumoylation, we examined sumoylation using ...
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Ataxia Telangiectasia-Mutated Damage-Signaling Kinase- and Proteasome-Dependent Destruction of Mre11-Rad50-Nbs1 Subunits in Simian Virus 40-Infected Primate Cells
... and Mre11-Rad50-Nbs1 (MRN) assemble with T antigen and other viral DNA replication proteins in large nuclear ...MRN complex, suggesting that MRN may undergo proteasome-dependent ...
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Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours.
... MRN complex with RAD50 and NBS1, and stability of the three MRN proteins is linked, with MRE11 mutations which destabilise the MRN complex being associated with reduced RAD50 and ...
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Möckel, Carolin (2011): Structural and functional analysis of ATP dependent conformational changes in the bacterial Mre11:Rad50 catalytic head complex. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... The Mre11:Rad50:Nbs1 (MRN; MRX in ...bacteria) complex describes such a keystone complex, involved in DSB sensing, nucleolytic processing of DNA ends, recruitment of DSB processing ...
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Mutations in Mre11 Phosphoesterase Motif I That Impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 Complex Stability in Addition to Nuclease Activity
... HE RAD50, XRS2, and MRE11 genes were first iden- tified in screens for ionizing radiation (IR)-sensitive or meiotic recombination-defective mutants in Saccha- romyces cerevisiae (S ymington ...in ...
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The Drosophila Nbs Protein Functions in Multiple Pathways for the Maintenance of Genome Stability
... and rad50 nbs double mutants are significantly higher than those observed in the corresponding single mutants (Table ...ATM/ Rad50/Mre11 ...homolog), Rad50, Mre11, and Xrs2 (the NBS ...
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The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius
... conserved Rad50 and Mre11 proteins must play important roles in these processes even if their precise function is still ...Eucarya, Rad50 and Mre11 proteins are associated with a third ...
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The Mre11p/Rad50p/Xrs2p Complex and the Tel1p Function in a Single Pathway for Telomere Maintenance in Yeast
... 1999 Nbs1 potentiates ATP-driven rates in transcriptionally active ...al., complex. Genes Dev. 13: 1276–1288. 1998 Complex formation and functional versatility of Mre11 of Porter, ...
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The Mre11/Rad50/Nbs1 Complex Limits Adeno-Associated Virus Transduction and Replication
... In order to examine second-strand synthesis in single cells, we recently developed a system to visualize the conversion of rAAV vector genomes from single-stranded to double- stranded DNA in real time. Our approach ...
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Temporal Regulation of the Mre11-Rad50-Nbs1 Complex during Adenovirus Infection
... the Mre11-Rad50- Nbs1 (MRN) complex to inhibit the DNA damage ...MRN complex due to E4-ORF6/E1B-55K does not occur until after viral DNA replication has ...MRN complex is ...
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Insight into the Mechanism of Inhibition of Adeno-Associated Virus by the Mre11/Rad50/Nbs1 Complex
... Mobilization of E1B55k/E4orf6 helper function in rAAV vec- tors. Ad proteins E1B55k and E4orf6 are required for productive infection with AAV during coinfection of these viruses and suffi- cient for enhancement of gene ...
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Aspergillus nidulans uvsBATR and scaANBS1 Genes Show Genetic Interactions during Recovery from Replication Stress and DNA Damage
... The Mre11 (Mre11-Rad50-Nbs1) protein complex has emerged as a central player in the human cellular DNA dam- age response, and recent observations suggest that these pro- teins are at ...
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Physical Interaction between the Herpes Simplex Virus Type 1 Exonuclease, UL12, and the DNA Double-Strand Break-Sensing MRN Complex
... The HSV-1 alkaline nuclease UL12 interacts with compo- nents of the cellular MRN complex during infection. Several HRR proteins, including Rad51, RPA, Ku86, ATM, and MRN, have been reported to localize to RCs (15, ...
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Differential Requirements of the C Terminus of Nbs1 in Suppressing Adenovirus DNA Replication and Promoting Concatemer Formation
... MRN complex may be involved in removal of the terminal protein from the end of the viral genome ...yeast Mre11 pro- tein has been implicated to function with the Sae2 protein in removal of covalently linked ...
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