MTDNA COPY NUMBER
Interrelation of chemerin and TNF-α with mtDNA copy number in adipose tissues and blood cells in obese patients with and without type 2 diabetes
... in mtDNA copy number in SAT and a decrease in mtDNA copy number in ...and mtDNA copy number in the Mes, as well as between mtDNA copy ...
11
Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number
... the mtDNA of 3–15 individual mature oocytes and three somatic tissues from eight zebrafish ...that mtDNA replication errors made during oogenesis are a likely ...variable mtDNA copy ...
9
The relationship between the mtDNA copy number in insulin-dependent tissues and markers of endothelial dysfunction and inflammation in obese patients
... The mtDNA copy number was determined by ...absolute number of copies of mtDNA per cell was calculated using the methods outlined below, using ...
6
Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients
... variable mtDNA copy number with clinicopathological characteristics of laryngeal cancer patients To further investigate the relationship of mtDNA con- tent with clinicopathological ...
9
Abstract: microRNAs can cause male infertility by impacting sperm
... in mtDNA copy number results in decreased sperm ...regulating mtDNA levels are not fully understood, it has already been proved that changes in TFAM protein levels directly influence ...
36
Association of mitochondrial DNA copy number with self-rated health status
... higher mtDNA copy number was associated with better self-rated health, while mitochondrial haplogroups were not associated (Table ...higher mtDNA copy numbers, while the number ...
7
Vitrification of Mouse MII Oocyte Decreases the Mitochondrial DNA Copy Number, TFAM Gene Expression and Mitochondrial Enzyme Activity
... level, mtDNA copy number; TFAM gene expression and mitochondrial enzymes activity (cytochrome C oxidase and succinate dehydrogenase) were assessed and compared with non-vitrified ...
9
Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome
... creases mtDNA copy number (Chen et ...nature, mtDNA changes that were present in all suppressor strains and absent from all nonsuppressor strains (or vice versa) could not be ...
18
Alteration of the copy number of mitochondrial coxi gene in the sperms of iraqi asthenozoospermic patients
... in mtDNA copy number during ...with mtDNA-depletion syndromes (Amaral et ...mitochondrial number and mtDNA content with higher ATP demands (Moraes et ...in mtDNA ...
6
Cadmium Exposure Disrupts Signaling of Placentation Pathways Involved in the Pathogenesis of Preeclampsia.
... Specifically, in Chapter 1 we show that Cd is capable of inducing metal-responsive and oxidative stress biomarker gene expression in placental JEG-3 cells. We also show that there are differences in gene expression ...
179
Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours
... a number of molecular check points at different stages of development, which include mtDNA replication turnover events ...sufficient mtDNA at E6.5 and cannot initiate mtDNA replication at this ...
18
Mitochondrial Dysfunction in Skeletal Muscle of Children With Cardiomyopathy
... We attempted to determine the molecular basis for the reduction in the levels of mitochondrial enzyme activities. Previously characterized pathogenic muta- tions (eg, a total of 12 sites) that have been shown to be ...
6
Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression
... functional mtDNA (see Figure ...without mtDNA could generate a ...of mtDNA and nucleoids could be part of PD ...without mtDNA or nucleoids can survive in culture because of the supportive ...
17
Variable copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in advanced gastric cancer patients
... of mtDNA content with clinicopathological characteristics and poor survival of gastric cancer patients, we categorized the patients into three groups based on two cutoff points (the lower and upper limit of 95% ...
9
Personalized medicine approach confirms a milder case of ABAT deficiency
... ABAT deficiency (OMIM 613163) is a rare inborn error of metabolism caused by recessive variants in the gene 4-aminobutyric acid transaminase (ABAT), which is responsible for both the catalysis of GABA and maintenance of ...
10
Gallo_unc_0153M_17684.pdf
... identified, which is a critical phase II metabolism gene that plays a role in detoxification in the cell (Hayes, Flanagan, & Jowsey, 2004). Our data displayed a negative association between GSTP1 expression and known ...
60
Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state
... amplify mtDNA were 5 ′ -CCTCCTAATAAGCGGCTCCT-3 ′ and 5 ′ -GGAGCTC GATTTGTTTCTGC-3 ′ , ...relative mtDNA copy number was normalized to a single-copy nuclear β -globin gene, and the ...
12
Polycystic ovary syndrome dependency on mtDNA mutation; copy Number and its association with insulin resistance
... The mtDNA content was determined in triplicate in using SYBR green PCR mastermix in QPCR (Applied Biosystems, Foster City) targeting the mitochondrial ND1 gene and normalized with using endogenous con- trol ...in ...
6
Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
... to mtDNA mutation load shifts upon muscle regeneration after muscle ...this mtDNA mutation shift was not observed in all ...the mtDNA mutation load in mesoangioblasts and satellite cells in parallel ...
10
ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions
... of mtDNA gene levels across 4-5 orders of magnitude that were much more clustered in single Purkinje neurons isolated from CTL ...these mtDNA genes, implying greater abundances of mtDNA deletions in ...
9