Multi-targeted Photoactivatable Platinum Anticancer Complexes
Photoactivatable platinum (IV) anticancer complexes
... of photoactivatable metal complexes is of crucial interest in the investigation of their ...of complexes 3-6 in water were determined, as described in Chapter 2 (section ...
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Photodecomposition pathways for photoactivatable platinum(IV) diazido anticancer complexes
... trans- platinum complexes synthesised and their cytotoxic ...trans-configured complexes in cis-platin resistant cell lines, suggested that these geometrical isomers induce their cytotoxic effect ...
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Synthesis, characterization, photochemistry and anticancer activity of novel photoactivatable platinum(IV) diazidodihydroxido complexes
... of platinum-DNA adducts. 15, 52 After administration of the platinum complex by intravenous injection, a large proportion of Pt II drugs are lost in the bloodstream before arriving at their ultimate target ...
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Photoactivatable cell selective dinuclear trans diazido platinum(IV) anticancer prodrugs
... of complexes for 2 h had no effect on EtBr ...dinuclear complexes 1 and 4 due to irradiation resulting in the release of two mononuclear fragments similar to those from ...
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New platinum and palladium complexes: their anticancer application
... compounds. Platinum complexes can, for example, be attached to doxorubicin, an anthracycline antibiotic which intercalates DNA and is commonly used in the treatment of various types of ...cancer. ...
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Supramolecular photoactivatable anticancer hydrogels
... The anticancer activity of diazido-Pt(IV) complexes is mainly due to photoreduction of inert Pt(IV) to cytotoxic Pt(II) together with release of reactive azidyl ...photoactive platinum-based ...
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Cucurbit[n]uril binding of platinum anticancer complexes
... multinuclear platinum complexes by cucurbit[n]uril ...of multi- nuclear platinum ...metal complexes through electrostatic interactions and hydrogen bonds with the ...
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Diazido platinum(IV) complexes for photoactivated anticancer chemotherapy
... Cinzia Imberti Cinzia Imberti obtained a M.Sci degree in Chemistry at the University of Padova (Italy) in 2012. She then obtained a PhD at King’s College London, working on the development of new radiometal-based radio- ...
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Mitochondria targeted spin labelled luminescent iridium anticancer complexes
... of platinum complexes has aroused wider interest in the design of metal-based anticancer ...of platinum drugs are their systemic toxicities and development of resistance, now a clinical ...the ...
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Multifaceted studies of the DNA interactions and in vitro cytotoxicity of anticancer polyaromatic platinum(II) complexes
... of targeted delivery of these complexes to cancerous ...for complexes 3–6; 4 and 5 were the most and least effective in both areas, respectively, while 3 and 6 were approximately equal in both DNA ...
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Sequence dependent attack on peptides by photoactivated platinum anticancer complexes
... to the oxidation of specic sites in both peptides. For SubP oxidation occurred only at Met, 11 whereas for K 3 -Bom, up to three stages of oxidation were observed: oxidation at Met 14 and a single or double oxidation of ...
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Computer aided drug design of photoactivated platinum anticancer complexes
... of platinum complexes have proven successful as anticancer agents in the clinic and in clinical ...the anticancer treatments in widespread use today were developed prior to 1975, at a time ...
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Interactions between anticancer active platinum complexes and non-coding RNAs/microRNAs
... Treatment of CRC (colorectal cancer) cells (HCT-8) with oxali- platin led to suppression of six oncogenic miRNAs (miR-92a, miR- 93, miR-191, miR-197, miR-222, miR-1826) which likely contrib- uted to the potent ...
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Photoactivatable Ru(II) polypyridyl complexes as antibacterial agents
... parallel to an adjacent bpy in order for a π-π interaction to occur (in 4 π-π interactions do not occur). Throughout the crystal structures of 4, 5 and 6 there is a wide array of hydrogen bonding. For 4 there is a dimer ...
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Photoactivatable organometallic pyridyl ruthenium(II) arene complexes
... other complexes so that their generation is ...potential anticancer agents with discriminating preference towards ...pyridine-derivative complexes, studies on CT-DNA interactions in cell-free media ...
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G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs
... as anticancer metallodrugs in clinics, their serious side effects and damage to normal tissues cannot be avoided because cisplatin kills cancer cells by attacking genomic ...for anticancer drug ...metal ...
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Design and development of polynuclear ruthenium and platinum polypyridyl complexes in search of new anticancer agents
... ruthenium-platinum complexes [Cl 3 Ru(dtdeg)PtCl]Cl (3), [Cl(bpy)Ru(dtdeg)PtCl]Cl 2 (4), and [(tpy)Ru(dtdeg)PtCl]Cl 3 (5) is ...the platinum moiety of the complexes is able to both intercalate ...
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Platinum anticancer drug shortages
... of platinum metal is very high. In June 2019 the spot price of platinum was US$814 per ounce, which is more than 50 times higher than the price of silver, but only 58% the cost of ...of platinum, it ...
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Photoactivatable metal complexes : from theory to applications in biotechnology and medicine
... The examples chosen are based on some of the presentations at the Royal Society Discussion Meeting in June 2012, many of which are featured in more detail in other articles in this issue. This is a young field. Even the ...
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Supporting Information - Synthesis and analysis of the. anticancer activity of platinum(ii) complexes. incorporating dipyridoquinoxaline variants
... Fluorescence binding data for complex 10, obtained from the first duplicate used: the emission spectra (top), Stern-Volmer plot (bottom left), and double-logarithm plot. (bottom right).[r] ...