Mutation Accumulation
Fitness Is Strongly Influenced by Rare Mutations of Large Effect in a Microbial Mutation Accumulation Experiment
... of mutation relies heavily on estimates of the rate and fi tness effect of spontaneous mutations generated by mutation accumulation (MA) ...of mutation accumulation, MA lines had ...
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Testing the Mutation Accumulation Theory of Aging Using Bioinformatic Tools
... The mutation Accumulation Theory of Aging proposes that random mutations with aging underlie, to some extent, the aging phenotype; here three proteins were mutated randomly and the effect of mutations ...
12
On the Rate and Linearity of Viability Declines in Drosophila Mutation-Accumulation Experiments: Genomic Mutation Rates and Synergistic Epistasis Revisited
... flawed. Mutation-accumulation experi- to create multiple MA lines, each of which was propagated by ments, however, are difficult to perform, and the magni- repeating the cross with a single Pm/⫹ male each ...
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A Test for Selection Employing Quantitative Trait Locus and Mutation Accumulation Data
... ABSTRACT Evolutionary biologists attribute much of the phenotypic diversity observed in nature to the action of natural selection. However, for many phenotypic traits, especially quantitative phenotypic traits, it has ...
15
The Relative Roles of Three DNA Repair Pathways in Preventing Caenorhabditis elegans Mutation Accumulation
... The above generalization, however, assumes that each of the three repair pathways was completely eliminated in each respective knockout surveyed, which is almost certainly not the case. For instance, despite the central ...
9
Multigeneration Maximum-Likelihood Analysis Applied to Mutation-Accumulation Experiments in Caenorhabditis elegans
... genomic mutation rates (U ) and average homozygous mutation effects (s) from mutation-accumulation (MA) experiments in which phenotypic assays are carried out in several ...if mutation ...
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Comparing Analysis Methods for Mutation-Accumulation Data: A Simulation Study
... in mutation-accumulation (MA) experiments, and we compared three methods of ...deleterious mutation had larger mean square error (MSE) than MD or BM had due to large ...deleterious mutation, ...
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Accelerating Mutational Load Is Not Due to Synergistic Epistasis or Mutator Alleles in Mutation Accumulation Lines of Yeast
... from mutation accumulation (MA) ...genetic mutation rates did not increase in the MA ...increased mutation rates in all lines during the last third of the lines’ ...deleterious mutation ...
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Behavioral Degradation Under Mutation Accumulation in Caenorhabditis elegans
... tions. This overall reduction in chemotaxic and locomo- Figure 2.—Change in behavior after 370 generations of tory ability was accompanied by a significant increase mutation accumulation. Average values for ...
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Mutation Accumulation in Populations of Varying Size: The Distribution of Mutational Effects for Fitness Correlates in Caenorhabditis elegans
... and Walsh 1998; Lynch et al. 1998). Sia et al. 1997; Weirdl et al. 1997; Buermeyer et al. 1999; Empirical evaluation of the relationship between pop- Flores and Engels 1999; Harfe and Jinks-Robertson ulation size and ...
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Essentiality is a strong determinant of protein rates of evolution during mutation accumulation experiments in Escherichia coli
... parallel mutation accumulation experiments in Escherichia coli, during 5,500–5,750 generations, and compared the genomes at different points of the ...
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Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation
... in mutation rates between stem cells and their differentiating descen- dants [11]; slower stem-cell cycling was reported to be favored when the stem-cell mutation rate was orders of magnitude lower than ...
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No Evidence of Elevated Germline Mutation Accumulation Under Oxidative Stress in Caenorhabditis elegans
... mev-1(kn1) mutation in worms is very well char- acterized (for review, see Ishii et ...the mutation is inserted into mammals and mamma- lian cell lines ...vated mutation rates in N2 if offspring born ...
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Increase of the Spontaneous Mutation Rate in a Long-Term Experiment With Drosophila melanogaster
... long mutation-accumulation ...terious mutation rates and average effects given in the literature may be explained by different transposition ...deleterious mutation rates of the order of ...
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The role of menopause and reproductive senescence in a long-lived social mammal
... This result may be spurious if repro- ductive cessation results from the mutation accumulation or attentive mother hypotheses, but it also suggests that killer whale mothers may be simil[r] ...
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Genomic Mutation in Lines of Arabidopsis thaliana Exposed to Ultraviolet-B Radiation
... deleterious mutation has been invoked as an important driving force in the evolution of many basic features of life, including sexual reproduc- tion, genome size, sex chromosomes, sexual selection, molecular ...
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Sex Slows Down the Accumulation of Deleterious Mutations in the Homothallic Fungus Aspergillus nidulans
... saline. Mutation accumulation protocol: The mutation accumula- tion procedure is depicted in Figure ...sexual mutation accumulation (MA) lines all started from one single ...
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Long Microsatellite Alleles in Drosophila melanogaster Have a Downward Mutation Bias and Short Persistence Times, Which Cause Their Genome-Wide Underrepresentation
... in mutation-accumulation lines suggests that long alleles have a mutation bias toward a reduction in the number of repeat ...size-dependent mutation spectra of microsatellite alleles may ...
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Age-Specific Patterns of Genetic Variance in Drosophila melanogaster. II. Fecundity and Its Genetic Covariance With Age-Specific Mortality
... We designed the present study to test the mutation accumulation model by estimating age-specific genetic variance components for fecundity, and to test the an- tagonistic [r] ...
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Quantitative Genetics of Ovariole Number in Drosophila melanogaster. II. Mutational Variation and Genotype-Environment Interaction
... riole number and body size were determined to be 4.75 and 1.97, respectively (Table 3). Similar studies of ab- dominal and sternopleural bristles on these lines yielded estimates of mutational heritabilities from 230 ...
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