Mutation frequency
\u3cem\u3eDACH1\u3c/em\u3e Mutation Frequency in Endometrial Cancer Is Associated with High Tumor Mutation Burden
... high frequency of both DACH1 and POLE mutations when compared to the TCGA PCA, and that POLE and DACH1 are significantly ...Notably, mutation frequencies of other common driver genes, PTEN, PIK3CA, and ...
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Deletion of human metapneumovirus M2 2 increases mutation frequency and attenuates growth in hamsters
... high frequency of readthrough ...increased frequency of readthrough at this gene junction may perturb the expres- sion of downstream genes such as SH, G and ...increased frequency of read-through ...
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Encephalitozoon intestinalis infection increases host cell mutation frequency
... host mutation frequency. To eliminate the possibility that mutation frequency was increased by DNA damage subsequent to pathogen-induced host cell death, dead cells were quantified in all ...
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Ribavirin Reveals a Lethal Threshold of Allowable Mutation Frequency for Hantaan Virus
... in mutation fre- quency reported earlier for HTNV (31), it does not provide additional insight into the operational mechanism of ...drug-induced mutation frequency in viruses (3, ...the ...
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MODIFICATION OF ULTRAVIOLET-INDUCED MUTATION FREQUENCY IN NEUROSPORA CRASSA
... Dependence of the effect of protein synthesis on the dose of UV: When the effect of leucine on the induced mutation frequency was studied as a function of the dose of[r] ...
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X Ray Induced Mutation Frequency at the Hypoxanthine Phosphoribosyltransferase Locus in Clinically Relevant Radioresistant Cells
... baseline mutation frequency at the HPRT locus was higher in HepG2-8960-R than in HepG2 (Figure 1(a) and Figure ...the mutation frequency, HepG2-8960-R were cultured for 3 weeks in medium ...
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Mutation Frequency and Specificity With Age in Liver, Bladder and Brain of lacI Transgenic Mice
... Mutation frequency and specificity were determined as a function of age in nuclear DNA from liver, bladder, and brain of Big Blue lacI transgenic mice aged ...in mutation frequency was ...
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The tRNA-Tyr Gene Family of Saccharomyces cerevisiae: Agents of Phenotypic Variation and Position Effects on Mutation Frequency
... ochre mutation, which acts as a reporter. The ochre mutation reverts to sense at a low frequency while tRNA-Tyr ochre suppressors (SUP-o) arise at a very high frequency to produce this ...
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Determination and Therapeutic Exploitation of Ebola Virus Spontaneous Mutation Frequency
... of mutation frequency of Ebola virus in ...the mutation frequency of EBOV, we utilized a re- combinant EBOV that carries the gene encoding green fluorescent protein (eGFP-ZEBOV) ...spontaneous ...
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Original Article SPOP mutation in prostate cancers in Korean population: variation in its mutation frequency among ethnic groups
... SPOP is Bric-a-brac/Tramtrack/Broad complex (BTB) protein that is a constituent of Cul3- based ubiquitination [10, 11]. The SPOP gene consists of two domains, the N-terminal MATH domain, which directly binds to steroid ...
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THE RELATIVE CONSTANCY OF THE X-RAY-INDUCED MUTATION FREQUENCY OF DROSOPHILA MELANOGASTER SPERM IN INSEMINATED FEMALES
... The results presented indicate that the physiological conditions of aging the sperm when it is in the female, Experiment I, either before or after the irradiation, or aging males pri[r] ...
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THE EFFECT OF MATING INTENSITY ON MUTATION FREQUENCY PATTERNS DETECTED AFTER IRRADIATION OF DROSOPHILA MELANOGASTER MALES
... FIGURE 4.- Patterns of mutation frequencies detected on successive days following irradiation with 4.000r of 3-day-old males subjected to three different intensities of mating[r] ...
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EXPERIMENTS TO TEST THE VALIDITY OF THE LINEAR R-DOSE/MUTATION FREQUENCY RELATION IN DROSOPHILA AT LOW DOSAGE
... placing the creamer on its side under the low power of the binocular microscope, magnification 7X, and checking for wi!d type males which could readily be identified at thi[r] ...
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Influence of laser beams combined with chemomutagen (MNU) on the variability of traits and mutation frequency in spring barley
... The study material consisted of seeds from three brewery cultivars of spring barley: Rudzik, Rambo and Boss. To induce mutation, a chemomutagen N-methyl-N- nitrosourea (MNU) was used at a dose of 1.0 mM. Before ...
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SOME BIOCHEMICAL ASPECTS OF THE POSTIRRADIATION MODIFICATION OF ULTRAVIOLET-INDUCED MUTATION FREQUENCY IN BACTERIA
... It is evident that if RNA and protein are involved in DNA replication and in mutation fixation (DOUDNEY and HAAS 1958, 1959a), then addition of agents blocking RNA or prote[r] ...
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MODIFICATION OF MUTATION FREQUENCY IN MICROORGANISMS. I. PREIRRADIATION AND POSTIRRADIATION TREATMENT
... Two explanations advanced to explain this time delay in mutation expression hold ( 1 ) gene mutation is induced immediately upon application of the mutagen to that particular gene [r] ...
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Higher frequency but random distribution of EGFR mutation subtypes in familial lung cancer patients
... EGFR mutation in lung adenocarcinoma patients with family history of lung ...EGFR mutation frequency and ...EGFR mutation types, we estimated the risk of exon 18 G719X, exon 19 deletions, and ...
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The effects of mutator plasmids on the frequency of mutation to nalidixic acid resistance in Escherichia coli
... However, mutation to nalidixic acid resistance was detected in AB1157(R46) at zero hours and in strains ABl 157 harbouring plasmids R46, R391 or pYDOl (Figure 22) after two hours exponential growth in nutrient ...
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Frequency of Epidermal Growth Factor Mutation Status and Its Effect on Outcome of Patients with Adenocarcinoma of the Lung
... The frequency of EGFR mutations is ethnicity-dependent, with a higher proportion in Asian popu- lation than in ...the frequency and spectrum of EGFR mutations in our popula- tion with lung adenocarcinoma, ...
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Original Article Prevalence of the frequency of JAK2 (V617F) mutation in different myeloproliferative disorders in Egyptian patients
... JAK2 mutation detection is now integrated in the diagnosis of ...(V617F) mutation in Egyptian patients with MPDs and our results are comparable to published literature in the ...12 mutation in JAK2 ...
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