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Non-small cell lung cancers.

DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers

DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers

... in non-small cell lung cancers ...corresponding non-malignant lung tissue (NL) samples from > 1,000 NSCLC patients, we found tumor-specific downregulation of ZNF677 ...

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Integrated molecular portrait of non-small cell lung cancers

Integrated molecular portrait of non-small cell lung cancers

... Human lung cancers are classified into two major sub- types, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with the latter accounting ...

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Original Article Increased tumor ZEB1 protein expression is correlated with poor prognosis in patients with non-small cell lung cancers

Original Article Increased tumor ZEB1 protein expression is correlated with poor prognosis in patients with non-small cell lung cancers

... promoting lung adenocarcinoma me- tastasis and antagonism of PI3K signaling could inhibit metastasis, suggesting promoting metastasis might be a mechanism of ZEB1 related short survival ...on lung cancer ...

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Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers

Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers

... tumor cell intrinsic and extrinsic mecha- ...for cell proliferation and apoptosis ...by small molecule inhibitors led to the transcriptional activation of p53, which in turn activates the expression ...

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Potential Oncogenic Role of the Papillary Renal Cell Carcinoma Gene in Non Small Cell Lung Cancers

Potential Oncogenic Role of the Papillary Renal Cell Carcinoma Gene in Non Small Cell Lung Cancers

... uncontrolled cell proliferation, which may con- tribute to lung ...repressed cell proliferation, suppression of invasiveness was also observed af- ter PRCC silencing in this ...

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Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions

Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions

... EGFR-mutant lung cancer cells in ...distinguish cell lines with mutated (mut) EGFR (red dots) and WT EGFR (blue dots) (n = ...EGFR-mutant cell lines (n = 8/54) was used for hierarchical clustering of ...

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Prevalence of driver mutations in non-small-cell lung cancers in the People’s Republic of China

Prevalence of driver mutations in non-small-cell lung cancers in the People’s Republic of China

... Currently, non-smoker lung adenocarcinoma is the principal subtype of lung cancer, and is recognized as a distinct entity because of its peculiar biological ...adenocarcinoma, non-smokers, and ...

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BCAT1 Overexpression Promotes Proliferation, Invasion, and Wnt Signaling in Non-Small Cell Lung Cancers

<p>BCAT1 Overexpression Promotes Proliferation, Invasion, and Wnt Signaling in Non-Small Cell Lung Cancers</p>

... We fi rst analyzed the expression patterns of BCAT1 in 107 cases of paraf fi n embedded NSCLC tissues and 15 cases of normal lung tissues using immunohistochemistry. Weak/ negative staining of BCAT1 was found in ...

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TRIM32 overexpression improves chemoresistance through regulation of mitochondrial function in non-small-cell lung cancers

TRIM32 overexpression improves chemoresistance through regulation of mitochondrial function in non-small-cell lung cancers

... HBE cell line and seven cancer cell lines including A549, H1299, H460, H358, H3255, H1975, and H2228 (Figure ...in lung cancer cell lines (especially H1299 and H2228) than in ...

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Multiparametric profiling of non–small-cell lung cancers reveals distinct immunophenotypes

Multiparametric profiling of non–small-cell lung cancers reveals distinct immunophenotypes

... B cell infiltrate and also B cells from matched normal lung and generated RNA sequencing (RNAseq) data with single-cell resolution (29, ...normal lung, 83 from tumor) passed our quality ...

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Original Article B7-H6 expression in non-small cell lung cancers

Original Article B7-H6 expression in non-small cell lung cancers

... (NK) cell cytotoxicity and cytokine secretion by binding natural cytotoxicity receptor ...65 non-small cell lung cancer (NSCLC) tissues and 65 matched adjacent non-tumor tissues ...

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Original Article PRR14 is an independent predictor of poor prognosis in resected non-small cell lung cancer patients

Original Article PRR14 is an independent predictor of poor prognosis in resected non-small cell lung cancer patients

... in lung tumor ...the cell migration [13, 14], motility and invasion [15-17] in ...in non-small cell lung cancers (NSCLC) (A), lung adenocarcinomas (ADC) (B) and ...

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EGFR T790M: revealing the secrets of a gatekeeper

<em>EGFR</em> T790M: revealing the secrets of a gatekeeper

... Abstract: Non-small-cell lung cancers that harbor activating mutations in the EGFR gene rep- resent an important molecularly defined subset of lung ...these cancers, the ...

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Anlotinib Suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT/ERK Signaling Cascade

<p>Anlotinib Suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT/ERK Signaling Cascade</p>

... stem cell factor receptor (c-Kit), has been developed independently in ...tumor cell growth, proliferation, angiogenesis, and metastasis in several human cancers, including non-small ...

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NON SMALL CELL LUNG CANCER: PRESENT TREATMENT AND UPCOMING IMPROVEMENTS

NON SMALL CELL LUNG CANCER: PRESENT TREATMENT AND UPCOMING IMPROVEMENTS

... Adjuvant Non-Small Cell Lung Cancer ...years, lung cancer specific survival, disease- free specific survival, and adverse events in curatively resected patients whose lung ...

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Original Article The expression of ERβ2, Bcl-xl and Bax in non-small cell lung cancer and associated with prognosis

Original Article The expression of ERβ2, Bcl-xl and Bax in non-small cell lung cancer and associated with prognosis

... [1]. Non-small- cell lung cancer (NSCLC) is the most common type of the lung ...the lung cancer cases throughout the world and the five-year overall survival rate is almost 15% ...

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Chemokines in tumor progression and metastasis

Chemokines in tumor progression and metastasis

... many cancers including esophageal squamous cell carcinoma [128], melanoma [129], non-small cell lung [130], head and neck [131], gastric [132], and colorectal ...

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Expression and prognostic relevance of Cyclophilin A and matrix metalloproteinase 9 in esophageal squamous cell carcinoma

Expression and prognostic relevance of Cyclophilin A and matrix metalloproteinase 9 in esophageal squamous cell carcinoma

... in non-small cell lung cancer, but overexpression of CypA was associated with decreased survival in various cancers, including endometrial car- cinoma, tongue squamous cell ...

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Mechanisms of resistance to ErbB targeted cancer therapeutics

Mechanisms of resistance to ErbB targeted cancer therapeutics

... cancer cell lines, namely A431 squamous carcinoma cells and HN11 head and neck carcinoma cells ...of nonsmallcelllungcancers that have acti- vating mutations in the kinase  ...

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1 2B adenosine receptor and cancer 2

1 2B adenosine receptor and cancer 2

... with non-small cell lung cancer, breast cancer, ovarian cancer, colorectal and six other types of cancers.. 473.[r] ...

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