Nrf2/ARE signaling pathway
Mechanisms underlying the perifocal neuroprotective effect of the Nrf2–ARE signaling pathway after intracranial hemorrhage
... of Nrf2 and HO-1 increase, whereas the expression of perifocal inflammatory substances NF- κ B and TNF- α decrease in the SFN ...the Nrf2–ARE signaling pathway may be involved in the ...
14
Original Article Glutamine ameliorates intestinal ischemia-reperfusion Injury in rats by activating the Nrf2/Are signaling pathway
... activates Nrf2/ARE sig- naling, we also evaluated whether GLN-induced Bcl2 expression was regualated by Nrf2 tran- scriptional factor in I/R ...of Nrf2 protein on two sites on Bcl2 pro- moter, and ...
9
Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells
... in Nrf2 signaling pathway by using 2 types of cells; mouse embryonic fibroblasts (MEFs) derived from wild-type (WT) and Nrf2 knockout (N0) ...
9
Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway
... To date, numerous compounds, including coumarins, flavonoids, quinones and polyphenols, are derived from natural products distributed extensively in vegetables, fruits and widespread medicinal plants. These compounds ...
15
Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
... [19]. Nrf2 pathway is regarded as the most important pathway in the cell to protect cells against oxidative stress ...of Nrf2 activity represents a critical step in initiating a cellular ...
9
Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review
... the Nrf2/Keap1 signaling pathway is the key player in regulating oxidative stress which may contribute to tumor ...formation. Nrf2 induces the expression of a battery of cytoprotective genes, ...
17
<p>The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation</p>
... major pathway of fi brogenesis which is activated in fi brotic ...downstream signaling pathway, Smad2, Smad3 and Smad7 were determined by RT-PCR and Western blot ana- lyses, so as to determine whether ...
16
Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
... Keap1-Nrf2 pathway is an emerging target for PC prevention and therapy. Indeed, Nrf2 plays an either tumor-suppressive or promoting function in PC, which depends on the developmental stages of the ...
15
Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification
... activate Nrf2 signaling pathway to induce PDAC cellular ...increased Nrf2 nuclear activity and induced transcription of genes involved in ROS detoxification and pentose phosphate ...that ...
14
Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer
... of NRF2 function, and the role of wild-type KEAP1 in negatively regulating NRF2 sig- naling has been well ...of NRF2 exon 2 in the four NSCLC cell lines demonstrated that no mutations existed in this ...
14
Inhibition of Nrf2/HO 1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis
... circumstances, Nrf2 is mainly present in the cytoplasm; however, when the level of ROS is elevated, the transcription of antioxidative stress proteins, including HO-1, is enhanced by Nrf2 [35, ...factor ...
13
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
... The NRF2 antioxidant pathway is known to play a critical role in combating fibrotic injury (Cho et ...rhythmic NRF2 activity may gate the tissue-protective responses to a fibrotic challenge in a ...
14
Brfl Post-Transcriptionally Regulates Pluripotency and Differentiation Responses Downstream of Erk MAP Kinase
... microRNA pathway, AUBPs are known regulators of splicing, mRNA stability, translational efficiency and RNA transport (68), and could provide an additional layer of developmental regulation that complements other ...
89
Identification of key pathways and genes in <em>TP53 </em>mutation acute myeloid leukemia: evidence from bioinformatics analysis
... receptor signaling proteins, serine-threonine kinase activity, and protein tyrosine kinase ...MAPK signaling pathway and pathways in cancer (Figure ...
11
Identification of key gene pathways and coexpression networks of islets in human type 2 diabetes
... apoptotic signaling pathway, and membrane depolarization during action potential were associated with the modules, ...B signaling pathway, tumor necrosis factor signaling path- way, ...
11
The Pharmacological Manipulation of the Nrf2 Pathway and Its Therapeutic Significance
... accumulated Nrf2 levels in the nucleus upon the removal of Nrf2 ...phosphorylating Nrf2 at Y568. Nrf2 is exported upon phosphorylation and targeted for ubiquitination by Keap1 (Jain et ...in ...
212
Identification of COX5B as a novel biomarker in high-grade glioma patients
... and pathway enrichment analysis were conducted, ...notch signaling, cell proliferation, cell-cycle arrest, and DNA repair and several other functional groups, which combine with the KEGG database, were ...
8
In silico identification of potential key regulatory factors in smoking-induced lung cancer
... Cancer is a complex disease and carcinogenesis in humans is a multistep process that transforms normal Cells into malignant derivatives so that investigation of the carcinogenesis from the systems perspective is ...
11
N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury
... As previously described, diverse proteins from the specimens were extracted. The Bradford method was applied for pro- tein concentrations. We used 10% or 12% SDS-PAGE to separate the proteins into different bands. Then ...
11
Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO 1 signaling
... of Nrf2 are supported by previous studies showing that Nrf2 gene ablation inten- sifies inflammation, oxidative stress and histological changes ...of Nrf2, is a natural pentacyclic triterpenoid that ...
10