NUCLEOTIDE ANALOG REVERSE-TRANSCRIPTASE INHIBITORS (NTARTIS
Natural Substrate Concentrations Can Modulate the Prophylactic Efficacy of Nucleotide HIV Reverse Transcriptase Inhibitors
... blocks reverse transcription by competing with the natural dATP substrate, we measured dATP contents in peripheral lymphocytes, lymphoid tissue, and rectal mononuclear ...of nucleotide reverse ...
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Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme
... nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/ NTRIs) and non-nucleoside reverse tran- scriptase inhibitors (NNRTIs), protease inhibitors and HIV integrase ...
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Resistance to Nucleoside Analog Reverse Transcriptase Inhibitors Mediated by Human Immunodeficiency Virus Type 1 p6 Protein
... protease, reverse transcriptase (RT), and ...nucleoside analog RT inhibitor (NRTI) antiretroviral therapy but was identified very rarely from drug- naı¨ve ...
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Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors
... available reverse transcriptase inhibitors (RTIs) at inhibiting the enzymatic activity of HK2 RT and HK2 genomic ...the nucleotide RTI inhibitor tenofovir (TDF), show efficacy in blocking K103 ...
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HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors
... nucleoside reverse trans- criptase inhibitors ...HIV-1 reverse transcriptase (RT) usually uses an ATP-de- pendent excision pathway to develop resistance to the nucleoside analog ...
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Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Target Distinct Phases of Early Reverse Transcription
... commercial reverse transcriptase ELISA (Table ...vitro reverse transcrip- tion on a homopolymer template by recombinant HIV-1 RT than against NERT in intact ...different nucleotide ...
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Mutations That Confer Resistance to Template-Analog Inhibitors of Human Immunodeficiency Virus (HIV) Type 1 Reverse Transcriptase Lead to Severe Defects in HIV Replication
... anti-HIV inhibitors, both their in vivo stability and delivery must be ...RNA-based inhibitors (2, ...protease inhibitors and nucleoside RT inhibitors, as well as nucleic acid-based ...
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Nucleotide priming and reverse transcriptase activity of hepatitis B virus polymerase expressed in insect cells.
... initiate reverse transcription in a protein-primed reaction that involves the covalent linkage of the first deoxyribonucleotide to the polymerase ...for reverse transcription; (iii) the products were small ...
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Potent Inhibition of Human Immunodeficiency Virus Type 1 Replication by Template Analog Reverse Transcriptase Inhibitors Derived by SELEX (Systematic Evolution of Ligands by Exponential Enrichment)
... HIV inhibitors, to be useful to a wider segment of the global population, they should be effective against a broad spectrum of HIV-1 variants, including variants resistant to antiretrovirals, as well as various ...
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Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
... Human immunodeficiency virus type 1 (HIV-1)-specific pyridinone reverse transcriptase (RT) inhibitors prevent HIV-1 replication in cell culture (M.. In contrast to nucleoside analog inhi[r] ...
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Genotypic, Phenotypic, and Modeling Studies of a Deletion in the β3-β4 Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene That Is Associated with Resistance to Nucleoside Reverse Transcriptase Inhibitors
... Stanford University, Stanford, 1 and Quest Diagnostics, San Juan Capistrano, 3 California, and Wayne State University, Detroit, Michigan 2 Received 2 December 1999/Accepted 19 August 2000 Point mutations and inserts in ...
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Effects of the Δ67 Complex of Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Nucleoside Analog Excision
... however, at this time, it is not clear which amino acid sub- stitution(s) is responsible for these effects. The ⌬67 complex was also tested for its ability to excise PMPA from the primer. PMPA differs from the other ...
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2D and 3D QSAR of Benzimidazole Analogues as Novel HIV-1 Non Nucleoside Reverse Transcriptase Inhibitors
... nucleoside/ nucleotide reverse transcriptase inhibi- tors (NRTIs/NTRIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease or entry inhibitors and HIV ...
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Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... multi-nucleoside analog drug resistance, led to a significant decrease in virus mutation ...HIV-1 reverse transcriptase p66 subunit open configuration with newly bound dATP, primer, and ...
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Virtual Screening for Novel HIV-Reverse Transcriptase Inhibitors
... world. Reverse transcriptase, protease and integrase are coded by the gag and gag–pol genes of HIV that shows a significant role in the repetition cycle of ...Viral reverse transcriptase (RT) ...
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Susceptibility of the Porcine Endogenous Retrovirus to Reverse Transcriptase and Protease Inhibitors
... nucleoside reverse transcriptase inhibitors (RTIs) were determined enzymatically for PERV and for wild-type (WT) and RTI-resistant HIV-1 reference ...protease inhibitors against ...
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Molecular Modeling of Potential Dual Inhibitors of HIV Reverse Transcriptase and Integrase
... dual inhibitors of HIV reverse transcriptase (RT) and integrase (IN), herein we report the molecular docking of an initial set of 556 compounds related to the pyridinone ...dual inhibitors of ...
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AZOLES AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NNRTIs): MINI REVIEW
... Two NNRTIs (nevirapine and delavirdine) have been formally licensed for clinical use and several others are (or have been) in preclinical and: or clinical development [tivirapine (TIBO R-86183), loviride (a-APA R89439), ...
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AN INSIGHT TO STRUCTURAL ANALYSIS OF COUMARINS AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
... O O O O OH In order to define ligand-receptor interactions, docking of all the low energy conformations within a range of 5 kcal/mol/Aº from the lowest energy conformation of each molecule, into the cavity of 3HVT, 1IKW, ...
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The Genetic Basis of HIV-1 Resistance to Reverse Transcriptase and Protease Inhibitors
... the reverse transcriptase (RT) and protease enzymes, the molecular targets of antiretroviral ...RT inhibitors, non- nucleoside RT inhibitors, and protease ...
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