ovariectomized rat
Pharmacological Investigation of Bonton Capsule for Anti-osteoporotic Activity in Ovariectomized Rat
... causes decrease in bone mineralization and formation process thus causes osteoporosis. The most common type of osteoporosis is the bone loss associated with ovarian hormone deficiency during and after menopause. 30 The ...
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Protective effect of calcitonin on lumbar fusion induced adjacent segment disc degeneration in ovariectomized rat
... Large numbers of patients undergoing lumbar fusion are the late-middle-aged and elderly population being treated for osteoporosis, which is characterized by a sys- temic impairment of bone mass and microarchitecture that ...
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Review article - Ovariectomized rat model of osteoporosis: a practical guide
... the ovariectomized rat model is the most commonly ...a rat model of osteoporosis by ovariectomy (OVX): (1) selection of the rat strain, (2) choosing the appropriate age of rats at the time of ...
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The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis
... In this study, we clearly demonstrated that the combina- tion treatment of ALF and RIS administered at their respective sub-therapeutic doses improved the mechani- cal properties of the lumbar spine and femoral midshaft ...
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Molecular analysis of the vaginal response to estrogens in the ovariectomized rat and postmenopausal woman
... and rat, and also a large degree of differential expression is expected, due to tissue-specific ...and rat for this tissue comparison to be the upper limit of what can be ...since rat and human are ...
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Phytoestrogens of Pachyrhizus erosus prevent Bone Loss in an Ovariectomized Rat Model of Osteoporosis
... The effects of the etyl acetate extract of root of Pachyrhizus erosus (L) Urb (EPE) on bone loss and in ovariectomized (ovx) rats model of osteoporosis were investigated. Forty-two 6-weeks- old female ...
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Bioactive Propolis and Bone Loss Reduction in an Ovariectomized Rat Model of Hypogonadal Osteoporosis
... Blood and urine biochemistry. Both alkaline phosphatase (ALP) and osteocalcin (OC) are produced by osteoblasts and are often used as markers of bone formation [19], while tartrate-resistent acid phosphatase (TRAP) is ...
5
The bromodomain inhibitor N-methyl pyrrolidone reduced fat accumulation in an ovariectomized rat model
... bones [24]. In the present study, we examined whether NMP could reduce obesity and obesity-related metabolic disorders in ovariectomized rats. During menopausal tran- sition, many women gain weight and weight gain ...
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Effect of extended term estrogen on voiding in a postpartum ovariectomized rat model
... The rat was placed in a fixed prone position at the edge of the mini operating table, leaving the caudal end of the animal hanging downward without touching the ...
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Rabbiteye blueberry prevents osteoporosis in ovariectomized rats
... The ALP activity in the OMG presented a sharp rise compared with those in the other groups and no signifi- cant difference between OBG and SG, suggesting that the rabbiteye blueberry diet played a bone-protective role in ...
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Combination therapy with low-dose teriparatide and zoledronate contributes to fracture healing on rat femoral fracture model
... an ovariectomized rat femoral fracture model, it was reported that ZA increased callus strength, bone mass:volume ratio, trabecular width, and trabecular connectivity density dur- ing the process of bone ...
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Overiectomized Model (Shyam Operated) and Femur Evaluation Parameters for the screening of antiosteoporotic Activity
... Mechanical support is the main function of the skeleton. Osteoporosis damages mechanical property of the bones and typically exposes elderly people, especially, to hip, spine and distal forearm fractures. Mechanical bone ...
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Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats
... clarified in post-menopause women and bilateral oophorec- tomy patients, as ascorbic acid has both an enhancing effect on adipogenesis of 3T3-L1 preadipocytes and a lipolytic ef- fect. Therefore, we tested the effect of ...
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Preliminary Study: Effects of Social Instability Stress on Depressive Behaviours in Ovariectomised Rats
... The animals received surgical operations to remove both ovaries (ovariectomized) under general anaesthesia using a combination of ketamine (Sigma, USA, 60 mg/kg) and xylazine (Sigma, USA, 5 mg/kg) ...
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The Dentete Gyrus Neuronal Density in Ovariectomized and Normal Rats
... Furthermore, induction of hippocampal LTP is facilitated in ovariectomized rats treated with estrogen as compared to untreated ovariectomized rats (1). Generaly, the results of present study indicated that ...
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Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes
... In this study, we explored the impact of menopause on the expression of genes related to the innate immune system in the rat and human cerebral cortex. We fo- cused on the potential alteration of the microglia ...
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Effect of lycopene on titanium implant osseointegration in ovariectomized rats
... Methods: Thirty female Sprague-Dawley rats were randomly divided into the following groups: OVX with vehicle (OVX group), OVX with lycopene (OVX + lycopene group) and sham-operated with vehicle (sham group). Twelve weeks ...
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Comparing the Effects of Various Estrogen Replacement Paradigms on Working Memory Performance in the Radial-Arm Maze
... the rat was placed in the center compartment with all doors leading to the arms ...The rat was allowed to enter any of the eight ...the rat traveled halfway down the length of an ...a rat ...
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The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
... each rat were taken for routine follow-up procedure and these samples were put in paraffin blocks. After the follow-up procedure, 5 µm wide sections were taken from paraffin blocks for histopathological ...
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EVALUATION OF ESTROGENIC ACTIVITY OF ALCOHOLIC EXTRACTS OF FRUITS OF SOLANUM XANTHOCARPUM USING PERCENTAGE VAGINAL CORNIFICATION AND VAGINAL OPENING AS ..
... are ovariectomized, the resultant lack of estrogen causes atrophy of the uterus and the reproductive tract; administration of estrogenic substances to ovariectomized rats leads to vaginal cornification and ...
8