Overlapping Genes
COMPARATIVE STUDY OF OVERLAPPING GENES IN THE GENOMES OF MYCOPLASMA HOMINIS AND MYCOPLASMA PENETRANS
... Overlapping genes are more conserved between species than non-overlapping genes mostly because a mutation in the overlapping region causes changes in both genes 11, 12 .... ...
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Same-strand overlapping genes in bacteria: compositional determinants of phase bias
... lapping genes in different phases are determined by their level of interdependence with respect to selective con- ...for overlapping genes in evolvable phases ...opposite-strand overlapping ...
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Gene Birth Contributes to Structural Disorder Encoded by Overlapping Genes
... in overlapping genes is an artifact of the process of de novo gene birth (Rancurel et ...nonoverlapping genes could re-encode an equiv- alent protein sequence as overlapping; instead, an ...
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Candidates in Astroviruses, Seadornaviruses, Cytorhabdoviruses and Coronaviruses for +1 frame overlapping genes accessed by leaky scanning
... new overlapping CDSs were identified using either MLOGD or analysis of conservation at synon- ymous sites within known ...the overlapping CDS is subject to fairly weak constraints at the amino acid ...novo ...
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Overlapping Genes Produce Proteins with Unusual Sequence Properties and Offer Insight into De Novo Protein Creation
... an overlapping open reading frame (ORF) as described in the NCBI file was incorrect, it was manually corrected (for instance, VP5 of infectious pancreatic necrosis aquabirnavirus starts at nucleo- tide 113 and not ...
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Overlapping genes in a yeast double-stranded RNA virus.
... One of the products of in vitro translation of the denatured viral double-stranded RNA is a polypeptide of the size expected of a capsid-polymerase fusion protein, resulting from a -1 fr[r] ...
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A comprehensive insight into the clinicopathologic significance of miR-144-3p in hepatocellular carcinoma
... 119 overlapping genes of the predicted targets of miR-144-3p, the NLP analysis and the differential expression genes of HCC in TCGA were performed in the STRING ...
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Probable presence of an ubiquitous cryptic mitochondrial gene on the antisense strand of the cytochrome oxidase I gene
... both in eukaryote and alpha-proteobacteria cells. This includes the use of monoclonal antibodies against the putative amino, central, and carboxyl terminal synthetic peptides of GAU proteins, Western blot analysis and ...
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Genomic and Transcriptomic Characterization of the New Human Glioblastoma Cell Line AHOL1
... expressed genes (DEGs) were ...druggable genes were identified, including HCRTR2, ETV1, PTPRD, PRKX, STS, RPS6KA6, ZFY, USP9Y and ...57 overlapping genes enriched in fourteen ...
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A statistical analysis of the three-fold evolution of genomic compression through frame overlaps in prokaryotes
... that overlapping sequences can overlap in different translational phases – the incidence of codon position pairings between ...in overlapping genes. Redundancy describes the ability of ...
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Gene overlapping and size constraints in the viral world
... 1 Overlapping rate is negatively correlated to genome ...of overlapping scenarios. The definition of overlapping in this study is restricted to the presence of two genes that overlap in their ...
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All in the family: proneural bHLH genes and neuronal diversity
... temporally overlapping phases (Jarman et ...just overlapping with it in time, is a transient phase of expression in ‘ intermediate groups ’ of up to ten ...
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The T box gene family: emerging roles in development, stem cells and cancer
... vertebrate genes (Dehal and Boore, 2005; Ruvinsky et ...vertebrate genes, Tbx1 and Tbx10, which presumably arose during one of the genome ...duplicated genes could have further evolved to take on ...
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PTEN opathies: from biological insights to evidence based precision medicine
... other genes encoding components of the PI3K/AKT/mTOR signaling pathway downstream of PTEN predispose patients to partially overlapping sets of clinical manifestations reminiscent of ...pathway genes ...
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A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes
... For the ‘The Cancer Genome Atlas’ (TCGA) dataset, RNAseqV2 normalized data (level 3, reads per kilobase per million mapped reads) of 518 primary HNSCC (421 HPV-negative and 97 HPV-positive) and 43 paired normal mucosa ...
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Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects
... expressed genes are involved in, Gene Set Enrichment Analysis (GSEA) [27] was ...downregulated genes, we identified 17 significant gene sets, including gene sets related to DNA replication and nucleotide ...
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Overlapping Patterns Recognition with Linear and Non Linear Separations using Positive Definite Kernels
... We proposed in this paper a kernel based overlapping k-means method to detect overlapping patterns in unlabeled data sets. The proposed method performs all the learning process in a high di- mensional ...
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Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
... A separate extension of the synthetic lethal principle might be to identify higher order synthetic lethal effects. Rather than single cancer driver genes being synthetic lethal with inhibition of a target (e.g. ...
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Prokaryotic expression of a VP1 polypeptide antigen for diagnosis by a human parvovirus B19 antibody enzyme immunoassay
... To produce parvovirus B19 antigen for diagnostic purposes, partially overlapping segments covering the genes encoding the viral structural proteins VP1 and VP2 were cloned into expressio[r] ...
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Simultaneous Positive and Purifying Selection on Overlapping Reading Frames of the tat andvpr Genes of Simian Immunodeficiency Virus
... Furthermore, overlapping reading frames add an additional complication to the estimation of R even at fourfold degenerate ...of overlapping reading frames, the effects of transitional bias and purifying ...
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