PAI-1
Original Article Meta-analysis of the association between endometriosis and polymorphisms in ACE and PAI-1
... In conclusion, this meta-analysis is the first to investigate the association between endome- triosis and polymorphisms of ACE and PAI-1. The results presented evidence for the associa- tion of ACE 2350 A/G ...
13
Lipoatrophy of the footpad in HIV-treated patients is associated with increased PAI-1
... Furthermore, the study also revealed a high prevalence of lipoatrophy in other body regions. The patients with plantar lipoatrophy were characterised by higher age, higher PAI-1, higher prevalence of ...
29
Elevated Tumor Expression of PAI 1 and SNAI2 in Obese Esophageal Adenocarcinoma Patients and Impact on Prognosis
... control medium (adjusted Po0.05) (Table 2). The top 10 differentially expressed genes (with adjusted P o 0.1) in each pathway were subsequently ranked by logFC; 9 belonging to the glycolysis pathway were listed, as only ...
9
Erratum to Hypoxia induced down regulation of microRNA 449a/b impairs control over targeted SERPINE1 (PAI 1) mRNA a mechanism involved in SERPINE1 (PAI 1) overexpression
... Figure six (figure 4 here) needed a substantial revision to allow a clear-cut interpretation of our findings. As stated in the results section, hypoxia per se induces i) down-regulation of miRNA-449a/b and also miRNA- ...
5
Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells
... candidate, PAI-1, which is highly secreted by glioma ...of PAI-1 in GBM is significantly correlated with shorter survival [11] and, that PAI-1 serum level could be attributed as ...
15
Significant associations of PAI 1 genetic polymorphisms with osteonecrosis of the femoral head
... plasma PAI-1 levels are highest in ONFH patients with the 4G/4G genotype, but that the incidence of ONFH is not related to genotype ...of PAI-1 on ONFH, we selected SNPs in the promoter and ...
7
Effects of teneligliptin on PDMPs and PAI-1 in patients with diabetes on hemodialysis
... We divided patients with diabetes into two subgroups according to whether they were receiving HD treatment or not. HD patients showed significant reductions in plasma concentrations of sP-selectin, PDMPs, and ...
7
synergistically increase PAI-1 expression in hepatic stellate cells of rats
... induce PAI-1 over-expression in HSCs, which is partially mediated by TGF-β 1 ...Increased PAI-1 expression may reduce the ECM degrada- ...in PAI-1 expression, Ald may ...
9
"Hypoxia induced down regulation of microRNA 449a/b impairs control over targeted SERPINE1 (PAI 1) mRNA a mechanism involved in SERPINE1 (PAI 1) overexpression"
... b 1-3) and bone morphogenetic proteins (BMPs) ...bitor-1, PAI-1) is an inhibitor of plasmin action and was shown to be a target of TGF b -1 which implicates cross- talks between the ...
14
Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments
... of PAI-1 knockout (PAI-1 − / − ) and wild-type (PAI-1+/+) male mice with a range of behavioral tests assessing depressive-like behaviors ( n = ...relating PAI-1 to ...
12
The cellular microenvironment modulates the role of PAI 1 and vitronectin in mediating cell matrix interactions
... [7-9], PAI-1 [10-12], complement proteins [13] and several cell surface receptors, including in- tegrins and the urokinase plasminogen activator receptor (uPAR) ...
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A small molecule inhibitor of PAI-1 protects against doxorubicin- induced cellular senescence
... that PAI- 1 inhibitor TM5441 efficiently decreases the levels of senescence in three major normal cell types ...and PAI-1 in a cell-type specific manner (Figure ...of PAI-1 using ...
15
Angiotensin induction of PAI 1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV
... Recent studies from this laboratory have demonstrated that angiotensin II (Ang II) stimulates the expression of plasminogen activator inhibitor 1 (PAI-1) in cultured endothelial cells. This response ...
7
uPA and PAI 1 as biomarkers in breast cancer: validated for clinical use in level of evidence 1 studies
... inhibitor PAI-1 (plasmino- gen activator inhibitor-1) - also meet most of the above ...and PAI-1 are among the best vali- dated biomarkers currently available for breast cancer, having ...
10
Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration and angiogenesis through increasing secretion of PAI-1
... of PAI-1 on CRC with overexpression of Rab11-FIP2, we used an anti-phos- photyrosine antibody array (Cell signaling Technology, #14471) to detect the phosphorylated or cleaved signal- ing ...the ...
13
High Concentrations of Plasminogen Activator Inhibitor-1 in Lungs of Preterm Infants With Respiratory Distress Syndrome
... (Fig 1, B and C). A positive correlation existed between the levels of PAI-1 and tPA in TAF during days 1 to 4 (days 1–2: ⫽ ...whereas PAI-1 and uPA showed no ...
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Plasminogen activator inhibitor 1 gene deficient mice II Effects on hemostasis, thrombosis, and thrombolysis
... heterozygous PAI-1-deficient (PAI-1+/-), and PAI-1-/- mice, respectively (P = ...for PAI- 1+/+ vs PAI-1-/- ...in PAI-1+/+ and ...
6
Expression of deleted in liver cancer 1 and plasminogen activator inhibitor 1 protein in ovarian carcinoma and their clinical significance
... and PAI-1 is a strong predictor of local, as well as distant me- tastasis ...of PAI-1 was significantly higher in epithelial ovarian cancer than in benign ovarian tumor which was detected by ...
8
Combination of Thrombophilic Gene Polymorphisms as a Cause of Increased the Risk of Recurrent Pregnancy Loss
... inhibitor 1 (7q21.3-q22) (PAI-1) promoter which produces two alleles containing either four (4G) or five (5G) consecutive guanosine nucleotides (PAI-1 - 675 4G/5G), resulting in ...
6
Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
... and PAI-1 regulate adhesion and migration of cells independently of, though influenced by, urokinase, implies an intrinsic duality of the uPA/plasmin sys- ...overexpressing PAI-1 (47), and in ...
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