Palmitic Acid (PA)

Top PDF Palmitic Acid (PA):

Oleic Acid Attenuates Palmitic Acid-Induced Impairments in Mouse Blastocyst Development

Oleic Acid Attenuates Palmitic Acid-Induced Impairments in Mouse Blastocyst Development

Palmitic acid (PA) and oleic acid (OA) are the most abundant saturated and monounsaturated non- esterified fatty acids, respectively, in serum. The consequences of PA and OA treatment on preimplantation mouse embryo development were investigated. It was hypothesized that OA treatment from the two-cell stage onwards would attenuate PA-induced reductions in mouse blastocyst development. PA significantly reduced development to the blastocyst stage. Transcript analysis revealed that PA increased ER stress pathway markers activating transcription factor 3 and C/EBP homologous protein transcripts, and XBP1 splicing. Co-culture of PA-treated embryos with OA prevented this PA-induced ER stress and rescued blastocyst development. Cytoplasmic lipid droplet accumulation was significantly increased by OA co-treatment. The results indicate that PA treatment induces ER stress, which limits lipid droplet accumulation and impairs blastocyst development. Co-treatment with OA is protective in reducing PA-induced ER stress and developmental impairments. These findings have applications in improving fertility outcomes for obese patients.
Show more

93 Read more

Investigation of Two Component Phase Diagrams of Oleic Acid- Palmitic Acid and Pentadecanoic Acid - Palmitic Acid Systems, Simple Green Experiments for Under Graduation Physical Chemistry Laboratory

Investigation of Two Component Phase Diagrams of Oleic Acid- Palmitic Acid and Pentadecanoic Acid - Palmitic Acid Systems, Simple Green Experiments for Under Graduation Physical Chemistry Laboratory

The use of the solid- liquid state equilibrium systems including oleic acid - palmitic acid and palmitic acid-pentadecanoic acid for undergraduate chemistry lab is a good alternative to naphthalene-phenanthrene, naphthalene-diphenylamine, or naphthalene-phenol systems. This replacement has several benefits, including: 1- Using them in repetitive educational labs and large groups is not associated with environmental or human health problems. 2. The waste is simply recyclable or can be used in other experiments, and even if not recycled, it simply decomposes in nature. 3. In these methods, all fatty acids have a melting point below 100°C, and testing with them can be done easily with a water bath. 4. Another advantage of these methods is the similarity of the two-component system derived from these fatty acids with respect to their identical structure, their similar structure with a simple system such as naphthalene-toluene, detecting the melting point of palmitic acid from the phase diagram and calculating the enthalpy of melting which is easily possible and provides the desired educational goals.
Show more

5 Read more

Elevated palmitic acid production in soybeans

Elevated palmitic acid production in soybeans

Soybeans (i.e., Glycine max L. Merr.) possessing a novel genetic determinant for the enhanced production of palmitic acid in the endogenously formed vegetable oil of the seeds are provided. Such genetic determinant is the homogeneous recessive fap5fap5 gene pair that has been found to be capable of formation through mutagenesis. Once formed, such genetic determinant can be readily transferred to other soybean lines and cultivars where it is similarly expressed on a reliable basis under conventional field growing conditions. In a preferred embodiment when a soybean plant possesses the combined presence of the homogeneous recessive genes (1) fap2-bfap2-b, (2) fap4fap4, as well as (3) fap5fap5 for enhanced palmitic acid formation in the seeds, it has been found that an unusually high expression for palmitic acid production in the resulting vegetable oil of the seeds is provided that is in excess of 30 up to approximately 37 percent by weight based upon the total fatty acid content. A resulting vegetable oil is made possible in this instance that is particularly well suited for margarine preparation in absence of the need for hydrogenation.
Show more

9 Read more

Soybeans and soybeans products having high palmitic acid content

Soybeans and soybeans products having high palmitic acid content

A method is described for producing soybean varieties and lines exhibiting palmitic acid contents of at least about 18.0% up to 30.0% or more. The novel soybean lines are obtained from a soybean seed designated A1937NMU-85 and its descendants, particular desirable progeny resulting from the cross of A1937NMU-85 with ElginEMS-421, and further with the cross of selected progeny with A89-259098.

9 Read more

Chlorogenic acid against palmitic acid in endoplasmic reticulum stress-mediated apoptosis resulting in protective effect of primary rat hepatocytes

Chlorogenic acid against palmitic acid in endoplasmic reticulum stress-mediated apoptosis resulting in protective effect of primary rat hepatocytes

Caspase-3 activity was detected by a Caspase-3 substrate kit. Cell apoptosis was detected by Hoechst 33342 staining. Results: We demonstrated that incubation of hepatocytes for 16 h with palmitic acid elevated cell death. Moreover, Western blot analyses demonstrated increased levels of the endoplasmic reticulum stress markers — glucose regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), and glucose regulated protein 94 (GRP94). Chlorogenic acid could inhibit ER stress induced cell death and levels of indicators of ER stress caused by palmitic acid. The effect of thapsigargin, which evokes ER stress were reversed by chlorogenic acid.
Show more

8 Read more

THE CHARACTERISTICS OF THE PERIPHERAL TRANSPORT OF C14 LABELED PALMITIC ACID

THE CHARACTERISTICS OF THE PERIPHERAL TRANSPORT OF C14 LABELED PALMITIC ACID

The majority of Gordon's observations PALMITIC ACID-1-C"4 AND TOTAL IPLASMA FREE FATTY ACIDS FFA DURING CONSTANT INFUSION OF PALMITIC ACID- of the arteriovenous differences of total FFA [r]

6 Read more

Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12

Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12

Here, we aimed at understanding the protective mech- anism of polyunsaturated fatty acid (PUFA) arachidonic acid (AA) against PA-mediated lipotoxicity. AA itself is the precursor of a number of biologically active metabo- lites formed by cyclooxygenase (COX) and lipoxygenase (LOX) pathways [16]. The eicosanoids such as prostaglan- dins (PGs) and leukotrienes(LTs), which are respectively produced by COX and LOX activity, play important roles in regulating many physiological processes and acute in- flammatory responses [17]. Additionally, an esterified AA is readily converted to phospholipids for membrane bi- layer or triglycerides for storage of energy [18]. Thus, to examine the preventive effect of polyunsaturated fatty acid AA on saturated fatty acid-mediated lipotoxicity, skeletal muscle cell C2C12 was supplemented with PA in the pres- ence of AA. For reference, an AA non-metabolic analogue eicosatetraynoic acid (ETYA) was also tested with respect to cytotoxicity, DNA fragmentation and cellular response to insulin to address whether AA metabolism is respon- sible for its beneficial effects. In our results, AA but not ETYA reversed completely the deleterious effects of PA on C2C12 cells such as cell damage, impaired glucose up- take and insulin signaling pathways.
Show more

10 Read more

Comparison of sterols and fatty acids in two species of Ganoderma

Comparison of sterols and fatty acids in two species of Ganoderma

of fatty acids was higher in cluster II. Palmitic acid, lino- leic acid, oleic acid and stearic acid were the main fatty acids in Ganoderma, which were in accordance with the previous reports for G. lucidum spore [15,36]. It was reported that fatty acids from the spores of G. lucidum could inhibit tumor cell proliferation. Nonadecanoic acid (C19:0) showed the highest inhibitory activity, fol- lowed by heptadecanoic acid (C17:0), stearic acid (C18:0, SA) and palmitic acid (C16:0, PA) [20]. Actually, saturated fatty acids including SA and PA are proapop- totic agents [37]. Unsaturated fatty acids LoA and OA have been revealed their anticancer activities [38-42] by activating GPR40 [38] and inducing oxidant stress and mitochondrial dysfunction [42] in cancer cell lines. Therefore, the similarity of two species of Ganoderma in fatty acids may be related to their antitumoral prolif- eration effect.
Show more

8 Read more

Feasibility of Using NIR Spectroscopy with SVM to Identify Kinds of Oil in Character Components

Feasibility of Using NIR Spectroscopy with SVM to Identify Kinds of Oil in Character Components

Using the established quantitative models of palmitic acid, oleic acid, linoleic acid, and iodine values, to predict the content of the four components of the predicted sample in the eight oil samples, and use this value as the prediction set of the qualitative model of the edible oil, and then use real content of the iodine value, palmitic acid, oleic acid, and linoleic acid in the calibration set as input values for the calibration set of the qualitative model in 129 samples, grid optimization, genetic algorithm, particle swarm and other methods were used to optimized the parameters of the classification model, establishing a quantitative-qualitative model based on the criteria of palmitic acid, oleic acid, linoleic acid and iodine value, and it’s parameters and test results as shown in Table 4.
Show more

6 Read more

In silico adme and biological activity assessment of natural phytoconstituents for anti alzheimer potential

In silico adme and biological activity assessment of natural phytoconstituents for anti alzheimer potential

Demethylwedalolactone, Valeranone, Jatamansin, Gamma gurjunene, beta-caryophyllene alpha humulin, Oleic acid, Palmitic acid, Linoleic acid, Gallic acid, Ellagic acid, Withafirin A, Withanolide D, Bacoside A, Bacoside B, Asiaticoside, Trans Asarone, Beta/cis asarone Glycyrrhizin, Glycyrrhizic acid and Licoisoflavanone were included in the present in silico analysis to evaluate their Anti-Alzheimer’s potential. The Bioactivity properties and drug-likeness of the above mentioned selected phytoconstituents were calculated using Molinspiration, Molsoft tools.
Show more

6 Read more

Characterization and Identification of Natural Terpenic Resins employed in “Madonna con Bambino e Angeli” by Antonello da Messina using Gas Chromatography–Mass Spectrometry

Characterization and Identification of Natural Terpenic Resins employed in “Madonna con Bambino e Angeli” by Antonello da Messina using Gas Chromatography–Mass Spectrometry

Actually, also palmitic acid/azelaic acid (P/A) and pal- mitic acid/oleic acid (P/O) ratios are important markers of the ageing process but it will be not discussed in this paper. A similar characterization was performed on the natural resin added to oil paintings for increasing flexibility in oil binders. A previous study [39] reported the detection of some characteristic molecules considered markers for nat- ural resins. In particular, among the diterpenic resins, dehydroabietic acid and 7-oxo-dehydroabietic acid are characteristic for Venice turpentine. The mass spectra
Show more

10 Read more

Genetic analysis of oleic acid and linoleic acid content in relation to oil quality in groundnut

Genetic analysis of oleic acid and linoleic acid content in relation to oil quality in groundnut

Fatty acid composition can be expressed as different quality parameters of oil. The magnitude of these parameters are directly proportional to the activity of individual enzyme systems (Cherif et al., 1975) believed to be responsible for desaturation of oleic acid and linoleic acid respectively. Stearic acid is one of the component fatty acids ranging from 2 to 4% of the total oil fraction of groundnut. Stearic acid has a neutral effect on blood serum LDL cholesterol concentration and is therefore a desirable constituent of oils for food use (Byfield et al., 2006). Stearic acid was associated positively with behenic acid and O/L ratio whereas it was negatively correlated with eicosenoic acid, lignoceric acid, polyunsaturated to saturated fatty acid ratio and palmitic to stearic acid ratio in both generations. Consumption of saturated fatty acids with a chain length of 8 to 16 has been related to increased blood low density lipoprotein cholesterol content, which is main cause of coronary heart diseases (Scarth and Tang, 2006). Total saturated fatty acids was associated positively with palmitic acid, linoelic acid, behenic acid, lignoceric acid, total long chain fatty acids, polyunsaturated to saturated fatty acid ratio, iodine value and palmitic to stearic acid ratio and it exhibited negatively association with oleic acid, O/L ratio, unsaturated to saturated fatty acid ratio and oleic acid desaturation ratio.
Show more

12 Read more

The Effects of 4-Hydroxybenzoic Acid
Identified from Bamboo (Dendrocalamus
asper) Shoots on Kv1.4 Channel

The Effects of 4-Hydroxybenzoic Acid Identified from Bamboo (Dendrocalamus asper) Shoots on Kv1.4 Channel

v/v)] followed by preparative TLC afforded cholest-4-ene-3-one. Lauric acid and palmitic acid were purified from the respective fractions by recrystallisation from hexane/methanol. Biocompounds isolated were identified using co-TLC comparing synthetic compounds and purified biocompounds from the extraction process. Chemical structures of all compounds were elucidated by using spectroscopic data of Electron impact–Mass spectrometry (EIMS) and Nuclear Magnetic Resonance Spectroscopy (NMR). EIMS were recorded by Shimadzu GCMS-QP5050 (Shimadzu, Kyoto, Japan). NMR data were recorded using BrukerAvance400 MHz (BrukerAvance, Massachusetts, USA). The isolation, purification and identification of the biocompounds were all done in Institute of Marine Biotechnology, Universiti Malaysia Terengganu (UMT), Malaysia.
Show more

13 Read more

 GC-MS ANALYSIS OF CHEMICAL CONSTITUENTS IN THE METHANOLIC TUBER EXTRACT OF MOMORDICA CYMBALARIA Hook. F.

 GC-MS ANALYSIS OF CHEMICAL CONSTITUENTS IN THE METHANOLIC TUBER EXTRACT OF MOMORDICA CYMBALARIA Hook. F.

The plant Momordica cymbalaria belongs to the family Cucurbitaceae. The Momordica genus found in the Indian states of Andhra, Karnataka, Madhya Pradesh, Maharashtra and Tamil Nadu. It is a wild crop well known as Athalakkai in Tamil. It is available in various parts of India, and it is a highly acceptable wild vegetable across south India. Tubers are reported to possess antioxidant and hepatoprotective activity. Roots are reported to possess anti- implantation activity. Fruits are reported to contain citric acid, malic acid and vitamin C. The fixed oil present in fruits of Momordica cymbalaria is reported to contain palmitic acid, oleic acid, stearic acid, α-Eleostearic acid and γ-Linolenic 14 .
Show more

6 Read more

A study of the fatty acid profile in the muscle of Monopterus chuchia

A study of the fatty acid profile in the muscle of Monopterus chuchia

A common constituents of glycerides of human adipose tissue, found in high concentration in liver, is palmitoleic acid. It is biosynthesized from palmitic acid, which is also detected in this fish species. Palmitoleic acid is present in considerable amount in Monopterus chuchia. It is a beneficial fatty acid which increases insulin sensitivity by suppressing inflammation and inhibits the destruction of pancreatic beta-cells which are known to secrete insulin 27 . Linoleic acid, which is a precursor of n-6

5 Read more

Characterization and Fatty Acid Composition of Amoora rohituka Seed and Leaf Oils

Characterization and Fatty Acid Composition of Amoora rohituka Seed and Leaf Oils

Fatty acid content of each of the petroleum ether (40-60°C) extracted oils of mature seeds and leaves of Amoora rohituka, has been analyzed for the first time by GC using standard fatty acids. Oil contents of the seeds and leaves were found to be 160.58 g/kg and 50.45 g/kg respectively (weight per kg dry materials). The oil of the seeds contained five identified fatty acids, accounting 88.85% of the total fatty acids and five unidentified compounds. The predominant fatty acids were oleic acid (46.7%), stearic acid (21.23%) and palmitic acid (19.46%).The leaf oil contained six identified fatty acids, accounting 84.21% of the total fatty acids and four unidentified compounds. The predominant fatty acids were palmitic acid (42.19%), oleic acid (19.27%), stearic acid (13.64%). It has been found that both seed and leaf oils of Amoora rohituka are rich in essential fatty acids and consequently the oils especially the seed oil may prove its worth as edible oil if considered from nutritional point of view.
Show more

6 Read more

DESIGN AND DEVELOPMENT OF NOVEL ORILISTAT CHEWABLE TABLETS FOR THE TREATMENT OF OBESITY

DESIGN AND DEVELOPMENT OF NOVEL ORILISTAT CHEWABLE TABLETS FOR THE TREATMENT OF OBESITY

Orlistat was a gift sample form Biocon pharmaceutical industry, Bangalore, India. Stearic acid, Palmitic acid, Lauric acid, Myristic acids and Mannitol are supplied from signet suppliers Mumbai in India. Methanol, Acetonitrile (HPLC), IPA, Ethanol, Ortho-phosphoric acids (88%), are supplied from Merck, Mumbai in India. Lactose, Talc, Magnesium stearate, SLS, SSG is supplied from S.D. Fine Chem limited, Mumbai in India. Sodium chloride, MCC is supplied from Chemiloids, Vijayawada in India. Cross carmallose, Calcium chloride, PEG, Povidone k30 are supplied from Bayir Chemicals, Bangalore in India. And melt granulation method.
Show more

12 Read more

CHEMICAL PROFILING OF TAVERNIERA CUNEIFOLIA (ROTH) ALI, A POSSIBLE SUBSTITUTE OF GLYCYRRHIZA GLABRA L  BY GC MS

CHEMICAL PROFILING OF TAVERNIERA CUNEIFOLIA (ROTH) ALI, A POSSIBLE SUBSTITUTE OF GLYCYRRHIZA GLABRA L BY GC MS

Palmitic acid, or hexadecanoic acid as its name indicates, it is a major component of the oil from palm trees (palm oil, palm kernel and palm kernel oil). It is mainly used to produce soaps, cosmetics and release agents. Sodium palmitate is permitted as a natural additive in organic products (US Soil Association standard 50.5.3).

6 Read more

Effects of Seasonal Variations on the Fatty Acid Composition of Total Lipid, Phospholipid and Triacylglicerol in the Dorsal Muscle of Mesopotamian Catfish (Silurus triostegus Heckel, 1843 ) in Tigris River (Turkey)

Effects of Seasonal Variations on the Fatty Acid Composition of Total Lipid, Phospholipid and Triacylglicerol in the Dorsal Muscle of Mesopotamian Catfish (Silurus triostegus Heckel, 1843 ) in Tigris River (Turkey)

The seasonal effects on the fatty acid composition of total lipid, triacylglicerol and phospholipid in the dorsal muscle of Silurus triostegus were determined by gas chromatographic (GC) method. The total polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) were the most important groups of total lipid and statistically ranged (P<0.05) from 33.88% to 55.85% and from 23.37% to 38.71%, respectively. The major fatty acids of total lipid in all seasons were palmitic acid (16:0) in SFA, oleic acid (18:1) in MUFA, linoleic acid (18:2) in n-6 PUFA, and docosahexanoic acid (22:6, DHA) in n- 3 PUFA. In the present study, n-3/n-6 ratios of total lipid were 2.47, 1.20, 1.03 and 1.40 in spring, summer, autumn and winter, respectively. It was determined that MUFA and PUFA were the most important groups of triacylglicerol and statistically ranged (P<0.05) from 34.09% to 47.02% and from 33.13% to 46.12%, respectively. The main fatty acids of triacylglicerol were palmitic acid in SFA, oleic acid in MUFA and linoleic acid in PUFA. PUFA was the most important group of phospholipid except summer. The total PUFA percentages of the phospholipid statistically ranged (P<0.05) from 38.12% to 65.75%. The major fatty acids identified in the phospholipid were palmitic acid in SFA, oleic acid in MUFA, arachidonic acid (20:4, AA) in n-6 PUFA and DHA in n-3 PUFA in all seasons. DHA was very high in winter (30.41%). It was shown that the fatty acid compositions in the muscle of fish were significantly influenced by seasons.
Show more

7 Read more

Effects of quantitative feed restriction and sex on carcass traits, meat quality and meat lipid profile of Morada Nova lambs

Effects of quantitative feed restriction and sex on carcass traits, meat quality and meat lipid profile of Morada Nova lambs

More feeding can explain the higher concentration of palmitic acid, palmitoleic acid, stearic acid and oleic acid in the meat of animals subjected to AL intake and 30% FR. These effects reflect the results observed with the IMF content. As 30% FR did not significantly influence the deposition of IMF, there was no effect on the com- position of fatty acids. The kinetics of the feed in the rumen may also have influenced the exposure time of the fatty acids to biohydrogenation [57]. The more severe restriction may have resulted in a lower passage rate, higher biohydrogenation, and higher deposition of SFA. Furthermore, the incorporation of fatty acids syn- thesized in muscle tissue may have been more effective in animals subjected to AL intake and 30% FR. This is related to a more lipogenic substrate for de novo synthe- sis in muscle adipocytes [58, 59], especially glucose from the propionate originating from the fermentation of carbohydrates in the rumen [60].
Show more

12 Read more

Show all 10000 documents...