paracrine signaling
A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells
... Cellular Mechanical Stimulation: Dynamic fluid flow was generated by placing rectangular (82mm x 92mm; 10mls of media) flasks on a rocking platform which oscillated at a frequency of 0.5 Hz and with an amplitude of 1.5cm ...
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Critical behavior of spatial networks as a model of paracrine signaling in tumorigenesis
... using paracrine signaling or an alternative mechanism that is essential for the tumor to enter the metastatic phase, and that the degree of mixing and separation between cellular pop- ulations could be a ...
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The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic Performance
... identified HDAC1 as a novel mediator of CMC cell fate decisions, wherein the targeted inhibition of HDAC1, via either shRNA-mediated depletion or entinostat (MS-275, SNDX-275) exposure, effectually promoted the ...
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Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators
... multiple signaling pathways by controlling proteasome-mediated degradation of signaling ...cilia-associated signaling pathways (Shh, Wnt, and Notch) in vitro and in ...Further, signaling ...
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EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF
... EMMPRIN, a cell adhesion molecule highly expressed in a variety of tumors, is associated with poor prognosis in cancer patients. Mechanistically, EMMPRIN has been characterized to contribute to tumor development and ...
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Cardio-renal Exosomes in Myocardial Infarction Serum Regulate Proangiogenic Paracrine Signaling in Adipose Mesenchymal Stem Cells
... ADMSC-mediated angiogenesis is stimulated after MI, and serum exosomes (MI Exo) mediate this activation. The major contribution of ADMSCs in angiogenesis is due to their endothelial differentiation and the proangiogenic ...
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Expression of genes involved in progesterone receptor paracrine signaling and their effect on litter size in pigs
... a paracrine mechanism to initiate decidualization after embryonic implantation, and also plays a fundamental role in preparing the epithelium for implantation through the regulation of Fkbps and Wnt ...active ...
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Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling
... one-way paracrine signaling indirect co-culture First, primary human fibroblasts were seeded into six- well plates (Grenier-Bio-One Cellstar, Frieckenhausen, Germany) at a density of 22,000 cells/cm 2 with ...
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Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity?
... for paracrine signaling pathways in mammary gland development was first sug- gested by studies in which there was a dissociation of the localization of estrogen receptor (ER)-positive and progesterone ...
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Paracrine signaling by glial cell–derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells
... the signaling pathways that control TH action in the ...a paracrine fashion to induce T3-responsive genes, including ecto- nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), in the cocultured ...this ...
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Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung
... Senescence in cancer cells acts as a tumor suppressor, whereas in fibroblasts enhances tumor growth. Senescence has been reported in tumor associated fibroblasts (TAFs) from a growing list of cancer subtypes. However, ...
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The hepatic stem cell niche and paracrine signaling by mesenchymal cells in support of human hepatic stem cells
... Cells in the ductal plates in fetal and neonatal livers and in the Canals of Hering in pediatric and adult livers are hHpSCs. They can be isolated efficiently by selective culture conditions and by immunoselection for ...
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Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning
... a signaling molecule needed for patterning of other regions of the central nervous system, including the hindbrain and the spinal cord (Maden, ...eye signaling molecules that control patterning or cell fate ...
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Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration
... Oncogenic signaling and GBM stressness have recently been linked to the depend- ence on lipids rather than glucose as a primary substrate for energy production [5, ...
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Mouse Disp1 is required in sonic hedgehog expressing cells for paracrine activity of the cholesterol modified ligand
... Finally, given that Hh ligands undergo a second lipid modification, an N-terminal palmitoylation, how does this relate to Disp1 function? Early studies first noted that when N- Shh was highly expressed in tissue ...
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IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling
... the paracrine signaling involved in bacterial quorum sensing, in which gene expression is regulated in response to fluc- tuations in cell-population density to shape bacterial com- munities ...such ...
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Pheromones Stimulate Mating and Differentiation via Paracrine and Autocrine Signaling in Cryptococcus neoformans
... a paracrine signaling role, activating morphological changes in mating partner cells that promote cell fusion and conjugation, similar to the role of pheromones in ...autocrine signaling role, ...
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Exosomes from mesenchymal stem cells induce the conversion of hepatocytes into progenitor oval cells
... the paracrine effects of MSCs on hepatocytes, MSC-CM was collected to treat the primary ...that paracrine signaling of MSCs converted hepatocytes into small, oval-shaped ...
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Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production
... Development of the vertebrate gut is controlled by paracrine crosstalk between the endodermal epithelium and the associated splanchnic mesoderm. In the adult, the same types of signals control epithelial ...
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Integrated compensatory network is activated in the absence of NCC phosphorylation
... Although further studies will be required to identify the fac- tors responsible for activating the paracrine signaling process, there is reason to suspect that hypokalemia and metabolic alka- losis are ...
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