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Pathologic Complete response

Effect of neoadjuvant chemotherapy regimen on relapse free survival among patients with breast cancer achieving a pathologic complete response: an early step in the de escalation of neoadjuvant chemotherapy

Effect of neoadjuvant chemotherapy regimen on relapse free survival among patients with breast cancer achieving a pathologic complete response: an early step in the de escalation of neoadjuvant chemotherapy

... a pathologic complete response (pCR) in a proportion of patients, with no residual invasive disease in the breast or nodes ...reflects response to chemotherapy and predicts ...tumor ...

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Radiologic complete response (rCR) in contrast enhanced magnetic resonance imaging (CE MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence free survival but not pathologic complete response (pCR)

Radiologic complete response (rCR) in contrast enhanced magnetic resonance imaging (CE MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence free survival but not pathologic complete response (pCR)

... Neoadjuvant chemotherapy (NACT) has become standard care for most patients with high-risk early breast cancer (EBC). This is especially true for triple-negative and human epidermal growth factor receptor (HER2)-positive ...

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Better pathologic complete response and relapse-free survival after carboplatin plus paclitaxel compared with epirubicin plus paclitaxel as neoadjuvant chemotherapy for locally advanced triple-negative breast cancer: a randomized phase 2 trial

Better pathologic complete response and relapse-free survival after carboplatin plus paclitaxel compared with epirubicin plus paclitaxel as neoadjuvant chemotherapy for locally advanced triple-negative breast cancer: a randomized phase 2 trial

... pathologic complete response (pCR) rate (28%) than those of anthracycline-based (20%) or taxane-based (12%) regimens [3]. It is believed to be the most effective regimen for TNBC in neoadjuvant ...

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Pathologic Complete Response (pCR) and Survival of Women with Inflammatory Breast Cancer (IBC): An Analysis Based on Biologic Subtypes and Demographic Characteristics

Pathologic Complete Response (pCR) and Survival of Women with Inflammatory Breast Cancer (IBC): An Analysis Based on Biologic Subtypes and Demographic Characteristics

... 23. Baron, P.; Beitsch, P.; Boselli, D.; Symanowski, J.; Pellicane, J.V.; Beatty, J.; Richards, P.; Mislowsky, A.; Nash, C.; Lee, L.A., et al. Impact of Tumor Size on Probability of Pathologic Complete ...

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Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer

Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer

... pCR: Pathologic complete response; PR: Progesterone receptor; PS: Prognostic Score; RFS: Recurrence-free survival; ROC: Receiving operat- ing curve; RPPA: Reverse phase protein ...

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Clinical parameters predicting pathologic complete response following neoadjuvant chemoradiotherapy for rectal cancer

Clinical parameters predicting pathologic complete response following neoadjuvant chemoradiotherapy for rectal cancer

... with pathologic complete response (pCR) to preoperative CRT have been reported to have better outcomes than those without ...the response to neoadjuvant CRT have not been well ...

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Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer

<p>Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer</p>

... Neoadjuvant chemotherapy (NAC) is initially recommended as the standard care for locally advanced inoperable breast cancer. In recent decades, lots of studies have indicated that preoperative chemotherapy in patients ...

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Density of CD8+ lymphocytes in biopsy samples combined with the circulating lymphocyte ratio predicts pathologic complete response to chemoradiotherapy for rectal cancer

Density of CD8+ lymphocytes in biopsy samples combined with the circulating lymphocyte ratio predicts pathologic complete response to chemoradiotherapy for rectal cancer

... tumor response to neoadjuvant chemoradiotherapy (nCRT) in rectal cancer, although the utility of these measures remains con- ...predicting pathologic complete response (pCR) after ...

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Pathologic complete response after preoperative anti HER2 therapy correlates with alterations in PTEN, FOXO, phosphorylated Stat5, and autophagy protein signaling

Pathologic complete response after preoperative anti HER2 therapy correlates with alterations in PTEN, FOXO, phosphorylated Stat5, and autophagy protein signaling

... Background: To define protein molecular characteristics of tumor cells prior to, and immediately following, preoperative human epidermal growth factor receptor 2 (HER2)-targeted therapy that correlate with ...

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Meta analysis on the association between pathologic complete response and triple negative breast cancer after neoadjuvant chemotherapy

Meta analysis on the association between pathologic complete response and triple negative breast cancer after neoadjuvant chemotherapy

... whether pathologic re- sponse after NAC predicts ...the pathologic response is prognostic for relapse-free survival, disease-free survival and overall sur- ...

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Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay

Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay

... Paradoxically, our results showed that the distribution of intrinsic subtypes, as assessed using IHC, between the patients with pCR or EF appeared to be similar even though they had a completely different prognosis. In ...

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The role of magnetic resonance imaging in assessing residual disease and pathologic complete response in breast cancer patients receiving neoadjuvant chemotherapy: a systematic review

The role of magnetic resonance imaging in assessing residual disease and pathologic complete response in breast cancer patients receiving neoadjuvant chemotherapy: a systematic review

... treatment response in imaging and pathology is ...imaging response assessment were observed in other cancer types, multiple response criteria were used in the selected studies [52, ...accepted ...

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A Case with Rectal Cancer Relapses After Clinical Complete Remission Following Neoadjuvant Chemoradiotherapy

<p>A Case with Rectal Cancer Relapses After Clinical Complete Remission Following Neoadjuvant Chemoradiotherapy</p>

... had complete disappearance of their tumors ...and pathologic complete response in nonsmoking patients treated with Neo-CRT for locally advanced rectal ...tumor response and risk factor ...

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Selective elimination of breast cancer surgery in exceptional responders: historical perspective and current trials

Selective elimination of breast cancer surgery in exceptional responders: historical perspective and current trials

... and pathologic complete response (pCR), there has been dramatic improvement in pCR rates in the past decade, especially among triple-negative and human epidermal growth factor receptor 2-positive ...

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The triple negative paradox_Primary tumor chemosensitivity of breast cancer subtypes.pdf

The triple negative paradox_Primary tumor chemosensitivity of breast cancer subtypes.pdf

... and pathologic response to neoadjuvant chemotherapy and examined the relationship of response to distant disease ^ free survival and overall ...Clinical response to AC was higher among the ...

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Current neoadjuvant treatment options for HER2 positive breast cancer

Current neoadjuvant treatment options for HER2 positive breast cancer

... overall response rate was significantly higher with lapatinib plus trastuzumab versus trastuzumab alone after six weeks and at the time of ...The pathologic complete response with the ...

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Fluorouracil-based neoadjuvant chemoradiotherapy with or without oxaliplatin for treatment of locally advanced rectal cancer: An updated systematic review and meta-analysis

Fluorouracil-based neoadjuvant chemoradiotherapy with or without oxaliplatin for treatment of locally advanced rectal cancer: An updated systematic review and meta-analysis

... A debate on whether the addition of OX as a neoadjuvant modality improves the clinical outcomes for LARC is ongoing [24]. To date, seven phase III randomized controlled trials investigated the effect of OX in ...

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NSABP FB 7: a phase II randomized neoadjuvant trial with paclitaxel + trastuzumab and/or neratinib followed by chemotherapy and postoperative trastuzumab in HER2+ breast cancer

NSABP FB 7: a phase II randomized neoadjuvant trial with paclitaxel + trastuzumab and/or neratinib followed by chemotherapy and postoperative trastuzumab in HER2+ breast cancer

... As expected, the major toxicity associated with nerati- nib in FB-7 is diarrhea. In the neratinib-alone and tras- tuzumab plus neratinib arms, nearly all patients experienced some diarrhea, with the occurrence of grade 3 ...

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A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

... the pathologic complete response (pCR) and local control rate, it decreased the pathological staging compared with preoperative radiotherapy, but failed to improve the long-term survival and ...

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Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer

Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer

... A pathologic complete response (pCR) following NAC implies the absence of residual invasive or in situ disease and corre- lates strongly with both prolonged disease-free survival and overall survival ...

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