PBPK Model
A physiologically based pharmacokinetic (PBPK) model of vitamin D
... PBPK model, this study was able to fit serum concentration data for circulating.. 21.[r] ...
26
A Parameter Analysis of a Physiologically Based Pharmacokinetic (PBPK) Model Describing the Movements of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Mouse
... (PBPK) model that describes the movement of TCDD around the body of a ...The PBPK model examined in this work contains five tissue compartments: liver tissue, spleen tissue, adipose tissue, ...
69
A simulation-based comparison between parametric and nonparametric estimation methods in PBPK models
... In this paper we have compared an MCMC parametric approach to a nonparametric method for the estimation of distributions in a hierarchical setting. Extensive computations using simulated data generated with a number of ...
99
Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
... The relevant CNS physiological compartments are the brain microvascular space, the cells of the barriers in the CNS (i.e. the BBB and BCSFB), the brain parenchymal cells, the brain extracellular fluid (brain ECF ), the ...
222
Mixed nanomicelles as potential carriers for systemic delivery of Z-GP-Dox, an FAPα-based doxorubicin prodrug: formulation and pharmacokinetic evaluation
... The mechanistic PBPK model was fitted to the experimental data and used to derive the pharmacokinetic parameters (Table 2). Comparison of tissue-plasma partition coef- ficient values (K p ) for ...
12
A multicompartment liver-based pharmacokinetic model for benzene and it's metabolites in mice
... The model described here extends a previous model that predicted tissue concentrations of certain metabolites in vivo in mice as a function of exposure using metabolic parameters obtained in ...a ...
28
Application of pharmacokinetics modelling to predict human exposure of a cationic liposomal subunit antigen vaccine system
... physiological model which best mimicked the kinetics of distributional transfer and degradation kinetics of the formulation at the key target site, namely the ...The PBPK model developed was able to ...
15
Physiologically based pharmacokinetic (PBPK) modeling of benzene in humans: a Bayesian approach
... benzene PBPK model is used in a human risk assessment, but we believe there is scientific value in first testing this more stringent assumption presented ...
33
Microdialysis: the key to physiologically based model prediction of human CNS target site concentrations
... CNS PBPK model that can predict human brain compartment concentrations on the basis of the physicochemical properties of a com- pound, which can be determined by in vitro measure- ments, or in silico ...
19
Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans
... the PBPK model used the actual concentra- tion-time profiles of both the inhibitor and substrate drugs to assess real-time interactions between ...in PBPK modeling, the concentration-time profiles of ...
14
Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models
... WB-PBPK model for ITZ and OH-ITZ was developed and linked to in vitro data of their CYP3A4 inhibition ...our model was that ITZ inhibits total CYP3A activity whereas it is actually specific to the ...
15
Physiologically based pharmacokinetic modeling of zinc oxide nanoparticles and zinc nitrate in mice
... NP-based PBPK model. A nanometal PBPK model with adequate predictive power can be used to investigate mechani- cal processes, evaluate hypotheses, and guide experimental designs and also has ...
16
Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory
... The aim of this paper was to develop an analysis frame- work to investigate whether population modelling approach can be used to estimate PBPK model parameters from clinical PK data and establish the ...
12
Physiologically Based Model Development and Parameter Estimation: Benzene Dosimetry in Humans and Respiratory Irritation Response in Rodents
... benzene PBPK model is used in a human risk assessment, but we believe there is scientific value in first testing this more stringent assumption presented ...
170
Species differences in the metabolism of pyrethroid pesticides : potential implications for human health risk assessment
... Pyrethroids are a class of synthetic pesticides derived from the pyrethrins, the natural insecticidal ingredients of the pyrethrum extract of Chrysanthemum cinerariaefolium. In an effort to aid species extrapolation of ...
190
Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study
... for rivaroxaban 20 mg-equivalent doses. The solid black line shows the geometric mean of the population prediction and the light grey shaded area denotes the 90% prediction interval of the PBPK model. The ...
12
From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II-Sensitivity to Physiological and Physicochemical Properties.
... the PBPK model (black lines), including the individual contribution of each system-specific parameter in the physiologically based model (nonsolid black ...
8
A Comparison of Physiologically-Based Pharmacokinetic (PBPK) Models of Methyl-Tertiary Butyl Ether (MTBE).
... 2. Does including kidney metabolism help explain renal carcinogenicity [in humans]? PBPK models do not often/always include metabolism in the kidney compart- ment. MTBE has been known to cause kidney damage in ...
135