Peptide T
Influence of epitope polarity and adjuvants on the immunogenicity and efficacy of a synthetic peptide vaccine against Semliki Forest virus.
... Humoral response to either the B-cell epitope peptide B, the T-helper cell epitope peptide T or the combination peptide T-B, using Quil A as an adjuvant Peptide used for immunization' B [r] ...
6
Continuous acquisition of MHC:peptide complexes by recipient cells contributes to the generation of anti graft CD8+T cell immunity
... to exclude the contribution of donor-derived DCs directly presenting OVA peptide, to CD8 + T cells, Act-mOVA- expressing mice were crossed with CD11c.DTR.GFP mice. In doing so, we created a model in which ...
9
Identification of epitopes in ovalbumin that provide insights for cancer neoepitopes
... of peptide 289–297 were not ...immunizing peptide for 12 ...each peptide tested in 9 different mice over 4 independent experiments; Welch’s t ...(257–264), peptide 176–183 (also ...
13
A Spirulina maxima-derived peptide inhibits HIV-1 infection in a human T cell line MT4
... synthetic peptide to identify the specific amino acid residues responsible for the anti-HIV-1 activity of SM-peptide; however, we were unable to perform experiments in cells because of the insolubility of ...
5
Portable flanking sequences modulate CTL epitope processing
... Transient peptide transfection endogenously replicates the effect of portable flanking sequences on epi- tope processing observed with in vitro degradation ...
14
Multiepitope CD8+ T cell response to a NY ESO 1 peptide vaccine results in imprecise tumor targeting
... + T cell response to a NY-ESO-1 peptide vaccine composed of the two previously defined peptides 157-165 and 157-167, administered with GM-CSF as a systemic ...NY-ESO-1 peptide vaccine elicited a CD8 ...
11
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
... cutaneous T-cell lymphoma patients with this mimotope induced initial tumor regression in both cases ...⫹ T-cells remains unknown, it has not been possible to compare the response generated by the native ...
21
T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones
... of peptide was used in order to ensure capture of all responses, although the use of 10 −7 and 10 −8 M peptide also worked well (data not ...of peptide for screening might result in the generation of ...
8
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity
... tetramer-positive T cell ...2.5 peptide, the recombinant peptide/MHC molecules, and pancreatic islets cells, confirming the cross-reactivity between the mimotope peptide and the islet antigen ...
14
Branched multipeptide immunotherapy for glioblastoma using human leukocyte antigen-A*0201-restricted cytotoxic T-lymphocyte epitopes from ERBB2, BIRC5 and CD99
... cytotoxic T-lymphocyte (CTL) epitopes in peptide immunotherapy for ...their peptide-T2 cell binding affinities and combined in a multipeptide cocktail or a branched multipeptide synthesized with ...
13
Necrosis-inducing peptide has the beneficial effect on killing tumor cells through neuropilin (NRP-1) targeting
... a peptide containing the mitochondrial targeting domain (MTD) found in Noxa, a BH-3 only protein of Bcl-2 family, induces ...fusion peptide of neuropilin-1 (NRP-1) targeting peptide and MTD ...
13
A short peptide eluted from the H-2Kb molecule of a polyomavirus-positive tumor corresponds to polyomavirus large T antigen peptide at amino acids 578 to 585 and induces polyomavirus-specific immunity.
... small T antigen and short synthetic peptides derived from the amino acid sequences of the three T antigens could evoke polyomavirus-specific immunity (23, 24, ...three T antigens was detected on the ...
5
Heat shock proteins 70 and 90 from Clonorchis sinensis induce Th1 response and stimulate antibody production
... + T cells were purified via negative selection using magnetic- activated cell sorting (MACS) columns (Pan T Cell Isolation Kit II; Miltenyi Biotec, San Diego, CA, ...Isolated T cells were stained ...
13
Gly→Ala Point Mutation and Conformation of Poly Ala Stretch of PABPN1: A Molecular Dynamics Study
... peptide B. The α-helical length is found to be stable in peptide B with starting geometry of a right handed helix, while in the case peptide A, the helical length is short. The interactions of water ...
10
Amelioration of arthritis through mobilization of peptide specific CD8+ regulatory T cells
... 18. Lu L, Kim HJ, Werneck MB, Cantor H. Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppres- sive activity and resolution of autoimmune disease. Proc Natl Acad ...
9
Characteristics of the Vδ2 CDR3 Sequence of Peripheral γδ T Cells in Patients with Pulmonary Tuberculosis and Identification of a New Tuberculosis-Related Antigen Peptide
... specific peptide in the form of a fusion protein on the phage ...␥␦ T cells in vitro using synthesized TCR ␦2 CDR3 peptides from tumor-infiltrating lymphocytes of ovarian epithelial carcinoma as specific ...
8
The Polyomavirus BK Large T-Antigen-Derived Peptide Elicits an HLA-DR Promiscuous and Polyfunctional CD4+ T-Cell Response
... ⫹ T cells (7, 14, ...the peptide used for cell ...Moreover, T-cell clones have not been studied to determine if the same or different populations of T cells react to these closely related ...
10
Brucella abortus conjugated with a gp120 or V3 loop peptide derived from human immunodeficiency virus (HIV) type 1 induces neutralizing anti-HIV antibodies, and the V3-B. abortus conjugate is effective even after CD4+ T-cell depletion.
... The difference in isotype patterns observed when B. abortus or KLH was used as carriers suggests that these carriers stim- ulate different cytokines in the immunized mice, probably as a consequence of stimulating ...
9
Improving therapeutic HPV peptide-based vaccine potency by enhancing CD4+ T help and dendritic cell activation
... CD8+ T cells and PADRE-specific CD4+ T cells in vaccinated ...49-57) peptide, 20 μ g/mouse of PADRE peptide or a combination of the two with or without treatment with 20 μ g/mouse of ...PADRE ...
10
Comprehensive Molecular Serology of Human Chlamydia trachomatis Infections by Peptide Enzyme-Linked Immunosorbent Assays
... trachomatis-specific peptide antigens from 8 proteins for use in ...trachomatis peptide antigens were compared to results from 4 commercial ...combined peptide ELISAs was confirmed by area under the ...
17