pertussis toxin
Detection of antibodies inhibiting the ADP ribosyltransferase activity of pertussis toxin in human serum
... For the direct ADPribosyltransferase assay, diluted serum samples were added to pertussis toxin, the mixture was incubated, and the entire contents of the mixture were assayed.. A total [r] ...
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Pertussis toxin inhibits neutrophil recruitment to delay antibody mediated clearance of Bordetella pertussis
... Bordetella pertussis disease. Thus it is critical to understand how B. pertussis remains endemic even in highly vaccinated or immune ...B. pertussis from the lungs. However, antibodies affected B. ...
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Neuropeptide Y and peptide YY inhibit lipolysis in human and dog fat cells through a pertussis toxin sensitive G protein
... catecholaminergic neurons, and (b) alpha 2-adrenergic receptors of adipocytes play a major role in the regulation of lipolysis, we investigated the effect of NPY and PYY on isolated fat cells. In human fat cells NPY and ...
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Pertussis Encephalopathy With High Cerebrospinal Fluid Antibody Titers to Pertussis Toxin and Filamentous Hemagglutinin
... of toxin(s) produced by Bordetella ...B pertussis, pertussis toxin (PT) has appeared to be the only likely candidate and has been postulated to act either directly on the central nervous ...
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Evaluation of an Immunoglobulin G Enzyme-Linked Immunosorbent Assay for Pertussis Toxin and Filamentous Hemagglutinin in Diagnosis of Pertussis in Senegal
... the pertussis toxin (PT) or against filamentous hemagglutinin (FHA) in paired sera correlates with Bordetella pertussis ...of pertussis has mainly been applied to unvaccinated children, with ...
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Establishment of Diagnostic Cutoff Points for Levels of Serum Antibodies to Pertussis Toxin, Filamentous Hemagglutinin, and Fimbriae in Adolescents and Adults in the United States
... of pertussis in adolescents and ...for pertussis is not routinely available to most clinicians, and the serologic test levels or cutoff points correlated with diseases have not been ...Bordetella ...
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Prospective Evaluation of an Australian Pertussis Toxin IgG and IgA Enzyme Immunoassay
... recent pertussis infection is an important part of both clinical assessment and epidemiological docu- mentation of this ...anti-pertussis toxin (PT) IgG titer is recommended as the most accurate ...
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Synergistic Neutralization of Pertussis Toxin by a Bispecific Antibody In Vitro and In Vivo
... Bispecific antibodies are a rapidly growing class of therapeutic molecules, originally developed for the treatment of cancer but recently explored for the treatment of autoimmune and infectious diseases. Bordetella ...
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Increase of the 40,000 mol wt pertussis toxin substrate (G protein) in the failing human heart
... bacterial toxin-catalyzed ADP ...wt pertussis toxin substrate (alpha G40) was increased by 36% in failing human hearts when compared with nonfailing ...
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Chemotactic peptide activation of human neutrophils and HL 60 cells Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation
... pertussis toxin. Upon stimulation with FMLP, the cytosolic-free calcium concentration, [Ca2+]i, is increased both by stimulation of calcium influx and mobilization of cellular calcium. We have measured ...
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Development and Analytical Validation of an Immunoassay for Quantifying Serum Anti-Pertussis Toxin Antibodies Resulting from Bordetella pertussis Infection
... diagnose pertussis in adolescents and adults are not widely ...Bordetella pertussis. Since concentrations of B. pertussis-specific antibodies tend to be high during the later phases of disease, a ...
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Analysis of Bordetella pertussis pertactin and pertussis toxin types from Queensland, Australia, 1999–2003
... Australian pertussis infection data appears to support this observa- tion, whereby from 1991 to 2002 approximately 60% of Australian pertussis notifications occurred in people over 10 years of age ...bal ...
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Development of a rapid diagnostic test for pertussis: direct detection of pertussis toxin in respiratory secretions
... In preliminary studies, one MAb IB12 was selected and used in an enzyme-linked dot blot immunoassay to evaluate the ability of the method to detect known amounts of PT in control experim[r] ...
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Human antibody response to the B oligomer of pertussis toxin.
... Serum samples from patients recovering from pertussis, as well as some of the purified Ig preparations, were able to inhibit the binding of PT to the 165-kDa glycoprotein at a 1:500 dilu[r] ...
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Multilocus Sequence Typing of Bordetella pertussis Based on Surface Protein Genes
... B. pertussis housekeeping genes (34; data not shown), we attempted to increase the likelihood of identifying allelic variation by analysis of genes coding for surface proteins, which may be subject to more ...
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Extracorporeal membrane oxygenation with prone position ventilation successfully rescues infantile pertussis: a case report and literature review
... for pertussis patients receiving ECMO support [4, 5], which is rather lower than other ECMO re- spiratory ...with pertussis is characterized by increased mass of leukocytes and high level of ...
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Bacterial toxins affect early events of T lymphocyte activation
... of pertussis toxin and cholera toxin on early events of T lymphocyte activation were examined in the T lymphocyte cell line, ...Jurkat. Pertussis toxin treatment of these T cells ...
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Human fat cell lipolysis is primarily regulated by inhibitory modulators acting through distinct mechanisms
... micrograms/ml) caused a two-to threefold increase in cyclic AMP, which was associated with an increase in glycerol release averaging 150-200% above basal levels. Clonidine, N6-phenylisopropyladenosine, prostaglandin E2, ...
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Seroprevalence of Pertussis among Danish Patients with Cough of Unknown Etiology
... that pertussis is only a childhood disease is not ...Bordetella pertussis provides only short-lived protection against pertussis—and the majority of the pop- ulation is consequently at risk of ...
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Adenylate cyclase toxin from Bordetella pertussis synergises with lipopolysaccharide to promote innate IL 10 production and enhance the induction of Th2 and regulatory T cells
... and pertussis toxin (PT)—activate DC that drive the differentiation of Th1 cells (8, ...cholera toxin (CT) (13), and candida albicans yeast hyphae (9) activate DC that drive the differentiation of ...
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