PI3K/mTOR
In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC
... dual PI3K-mTOR and MEK inhibitors have been investigated in combination in the clinic [19, 29, ...of PI3K pathway signalling in cisplatin-resistant NSCLC, where GDC- 0980 was shown to induce a ...
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Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression
... leukemia (ALL) cell lines both in vitro and in vivo [3, 4]. However, the effect on in vivo growth inhibition was mar- ginal. To understand why cells display poor response to PKI-587, we used a panel of 25 acute leukemia ...
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Indolent peritoneal mesothelioma: PI3K-mTOR inhibitors as a novel therapeutic strategy
... Both patients subsequently achieved tumour shrinkage with apitolisib, the PI3K-mTOR inhibitor. Case 1 had symptomatic improvement, normalisation of the CA-125, a maintained radiological partial response and ...
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In vitro assessment of antitumor activities of the PI3K/mTOR inhibitor GSK2126458
... Intracellular caspase-3 was assessed by immunope- roxidase staining and by the synthetic cell-permeable caspase-3 substrate Ac-DEVD-AMC. Other utilized apop- totic biomarkers were immunoperoxidase staining for cytochrome ...
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Ablation of PI3K blocks BCR ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR ABL+ leukemia cells
... IA PI3K in the murine pre–B-ALL model but has not distinguished the roles of different isoforms (5, 10, ...reduces PI3K signaling output to an undetectable ...IA PI3K expression and ...
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Acetylshikonin Inhibits Colorectal Cancer Growth via PI3K/Akt/mTOR Signaling Pathway
... Acetylshikonin for 48 h. Both adherent and floating cells were collected. The tumour tissue protein was purified according to the reported method [11]. Western blotting used standard protocols. Proteins were separated by ...
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T cell receptor signaing controls Foxp3 expression via PI3K, Akt and mTOR
... and PI3K/mTOR inhibition, consistent with a recent two-stage model of Treg dif- ferentiation in which TCR signals are required for the up-regulation of genes like Cd25 that predispose to Treg ...
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PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma
... Thus, we investigated whether combination of Dox and PI3K/mTOR inhibitors would have synergistic effects on LMS growth in vitro. Furthermore, we investigated whether these drug combinations should be ...
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Original Article The exosome-mediated PI3k/Akt/mTOR signaling pathway in cervical cancer
... the PI3k/ Akt/mTOR signaling pathway is associated with the tumorigenesis and malignancy of cervical ...the PI3K/ Akt/mTOR signaling pathway are also hot drug design targets, and the ...
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Activation of IGF1R/p110β/AKT/mTOR confers resistance to α specific PI3K inhibition
... The PI3K pathway is one of the most attractive therapeutic targets and numerous inhibitors are being evaluated in clinical trials ...block PI3K activity, which may not result in acceptable ...dual ...
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Developing a novel dual PI3K–mTOR inhibitor from the prodrug of a metabolite
... dual PI3K–mTOR inhibitors, which explains the slow progress of research and development of these inhibi- ...dual PI3K–mTOR inhibitors are being evaluated actively in the clinical stage, but ...
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NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/ mTOR phosphorylation
... Background: Patients harboring activating mutations in epidermal growth factor receptors (EGFR) are particularly sensitive to EGFR tyrosine kinase inhibitors (TKIs). However, most patients develop an acquired resistance ...
9
PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
... both PI3K and mTOR. PI- 103 was the first dual mTOR/PI3K inhibitors that inhibited mTOR in an ATP-competitive manner ...promising PI3K/mTOR dual inhibitor exhibiting ...
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Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy
... 24. Li, Y., Inoki, K., Vacratsis, P. and Guan, K.L. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J. Biol. Chem. 278 (2003) ...
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Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and/or autism
... the PI3K-AKT-mTOR pathway had features of megalen- cephaly and/or brain overgrowth, rather than macro- cephaly ...the PI3K-AKT-mTOR pathway and macrocephaly and DD/ID/ASD is relatively new, we ...
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Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway
... In the present study, the results showed that Nano-SiO 2 can induce autophagic activity, accompanied by NO/NOS system disorder and an inflammatory response, eventually leading to endothelial cell dysfunction via the ...
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Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
... the PI3K/Akt/mTOR pathway via RAGE, while blockage RAGE re-activated PI3K/Akt/ mTOR pathway, however, the addition with PI3K inhibitor redeuced the cell autophagy and improve the cell ...
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Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
... of PI3K/AKT/mTOR in regulating glycolytic metabolism An increasing number of studies have demonstrated that cellular metabolism also plays an essential role in regulation of pluripotency, specifically ...
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The PI3K-AKT-mTOR pathway activates recovery from general anesthesia
... of PI3K-AKT-mTOR pathway in recovery from general ...and PI3K/Akt agonists (Group ...of PI3K-AKT-mTOR pathway were measured by RT-qPCR and Western ...in PI3K-AKT-mTOR ...
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PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
... of PI3K or Akt, or deletion of phosphatase and tensin homolog (PTEN) in mouse embryonic fibroblasts (MEFs) also suppresses PDGFR ...of mTOR activation, since rapamycin restored PDGFR expression and PDGF- ...
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