Pioglitazone hydrochloride
Estimation of Pioglitazone hydrochloride in Bulk and Pharmaceutical dosage form by UV- Spectroscopy
... Sample label claim 30 mg. The average weight was determined with 20 tablets, which were grounded in a mortar until fine powder. Accurately weighed amount of powder equivalent to 10mg of pioglitazone ...
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SOLVENT EVAPORATION METHOD FOR AMORPHOUS SOLID DISPERSIONS: PREDICTIVE TOOLS FOR IMPROVE THE DISSOLUTION RATE OF PIOGLITAZONE HYDROCHLORIDE
... Pioglitazone HCl release from the solid dispersion and alone was studied in phosphate buffer (pH 7.4) up to 2 hours. The average percentage release of the pure Pioglitazone HCL was found to be 46% in 2 ...
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A Validated Stability Indicating HPLC method for the Determination of Impurities in Pioglitazone Hydrochloride
... for Pioglitazone hydrochloride in the presence of its impurities and degradation products, generated from forced degradation ...of Pioglitazone hydrochloride was observed under base and ...
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Formulation, Evaluation and Characterization of Solid Dispersions of Pioglitazone Hydrochloride
... The aqueous solubility of Pioglitazone hydrochloride was found to be 0.05mg/ml, and the drug release was found to be only 23.5% during the in vitro dissolution study in pH 2.0 buffer, suggesting a strong ...
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Dissolution enhancement of pioglitazone hydrochloride using β- cyclodextrin
... Pioglitazone hydrochloride is an oral anti diabetic ...of Pioglitazone by preparing β- cyclodextrin complexes in different ...containing pioglitazone hydrochloride: β cyclodextrin in ...
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FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF PIOGLITAZONE HYDROCHLORIDE BY EMPLOYING MODIFIED SUPERDISINTEGRANTS
... of Pioglitazone Hydrochloride: The in vitro dissolution study was carried out in the USP dissolution test apparatus (EDISON-[ESI-06] Dissolution tester USP) type 2 ...
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FABRICATION AND CHARACTERIZATION OF GASTRORETENTIVE MUCOADHESIVE MICRO PARTICULATE SYSTEM OF PIOGLITAZONE HYDROCHLORIDE FOR SUSTAINED DELIVERY
... Pioglitazone Hydrochloride was gifted by Ranbaxy Laboratories Limited, Goa, ...of Pioglitazone Hydrochloride Mucoadhesive Microspheres ...
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RP- HPLC method for Simultaneous Estimation of Pioglitazone Hydrochloride Metformin Hydrochloride and Glibenclamide in Multicomponent Tablet Dosage Form
... development. Pioglitazone hydrochloride (PIO) is chemically, (±)-5- [p-[2-(5-ethyl-2-pyridyl)-ethoxy] benzyl]-2, 4- thiazolidinedione hydrochloride (Fig 1a), is an oral antidiabetic agent used in the ...
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Analytical Method Development And Validation For The Estimation Of Pioglitazone Hydrochloride By Using RP-HPLC
... Linearity: The linearity of detector response is determined by plotting a graph with series of standard concentration range of 10- 18μg/ml with concentration on X-axis and absorbance on Y-axis at 268nm. The correlation ...
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Estimation of Metformin Hydrochloride and Pioglitazone Hydrochloride in their Bulk and Formulation Dosage fForms by using RPHPLC Method
... 15. Shankar Madhira B, Modi Vaibhav D,Shah Dimal A, Bhatt Kashyap K, Mehta Rajendra S, Geetha Madhira et al., Estimation of Pioglitazone hydrochloride and Metformin hydrochloride in tablets by ...
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Analytical method development and validation of pioglitazone hydrochloride by RP HPLC
... of pioglitazone hydrochloride [(± pyridinyl) ethoxy] phenyl] methyl]-2,4- ...of Pioglitazone is carried out using a reversed-phase Intersil ODS C18 (150 mm × ...in Pioglitazone ...
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Design and characterization of pioglitazone hydrochloride mucoadhesive microspheres
... The result of physical test of the formulations with different mucoadhesive agents like xanthan gum, guar gum, gum kondagogu, gum olibanum different formulations of pioglitazone hydrochloride microspheres ...
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Hypoglycemic Study of Fe(II) and Zn(II) Complexes of Pioglitazone Hydrochloride on Wistar Albino Rats using Alloxan Induced Method
... The present study deals with the synthesis and hypoglycemic activity of Fe(II) and Zn(II) complexes with Pioglitazone hydrochloride a new oral antidiabetic drug. The conductometric titration using ...
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REVERSE PHASE LIQUID CHROMATOGRAPHY DETERMINATION OF ATORVASTATIN CALCIUM AND PIOGLITAZONE HYDROCHLORIDE IN TABLET DOSAGE FORM
... Resolution is the most important criteria for the method, it is imperative to achieve good resolution among the compounds. As per the value of Ka and solubility of compound various composition of mobile phase were tried. ...
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DEVELOPMENT AND EVALUATION OF MICROBALLOONS OF PIOGLITAZONE HYDROCHLORIDE USING EUDRAGIT S 100
... Pioglitazone hydrochloride (PH) acts as an agonist at peroxisome proliferator-activated receptors (PPARs) in target tissues for insulin action, such as adipose tissue, skeletal muscle, and ...
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DEVELOPMENT AND VALIDATION OF A STABILITY–INDICATING HPLC UV METHOD FOR THE DETERMINATION OF PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE IN BULK DRUG AND COMBINED DOSAGE FORM
... Pioglitazone hydrochloride, (±)-5-{[[4-2-(5-ethyl-2-pyridinyl) ethoxy] phenyl]methyl}-2,4-thiazolidinedione monohydrochloride (PIO) , is an oral anti-hyperglycemic agent belongs to the thiazolidinedione ...
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ESTIMATION OF PIOGLITAZONE HYDROCHLORIDE BY UV SPECTROPHOTOMETRIC METHOD
... Pioglitazone hydrochloride, a widely prescribed anti diabetic drug belongs to class IΙ under BCS and exhibit low and variable oral bioavailability due to its poor aqueous ...
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Effect of Solutol HS 15 in Solid Dispersions of Pioglitazone Hydrochloride: in vitro and in vivo Evaluation
... of pioglitazone hydrochloride through preparation of stable solid dispersions by melting and solvent evaporation method using Solutol HS ...of pioglitazone hydrochloride was enhanced by 9 to ...
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Potentiometric Sensor for Quantitative Analysis of Pioglitazone Hydrochloride in Tablets Based on Theoretical Studies
... Recently, electrochemical methods for fast and online monitoring of drugs have been developed which are based on cyclic voltammetry and potentiometry [10-18]. Potentiometric sensors have been used in analysis of some ...
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STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PIOGLITAZONE HYDROCHLORIDE AND ALOGLIPTIN BENZOATE IN PHARMACEUTICAL FORMULATION
... inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). DPP-4 inhibitors represent a new therapeutic approach to the treatment of type 2 diabetes that functions to stimulate glucose dependent insulin release ...
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