PK-PD model
Research on the mechanism of drug–drug interaction between salvianolate injection and aspirin based on the metabolic enzyme and PK PD model: study protocol for a PK PD trial
... A combination of salvianolate and aspirin may provide an effective and safe therapeutic option for patients with CHD; however, its DDI mechanism remains unclear. We investigate this inquiry by applying a ...
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Variability of plasma concentrations of Amitriptyline and its metabolite Nortriptyline by Blood Pressure Alterations in Patients of Depression: A PK/PD Model
... of PK/PD model makes it possible to understand the quantitative relationships and describes how drugs work by relatively simple concept that can be used to optimize the best outcome of drug therapy ...
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A SIMPLE NON INVASIVE COMPARATIVE LOG LINEAR PK PD MODEL OF DEXIBUPROFEN TABLETS IN INDIAN HEALTHY HUMAN MALE VOLUNTEERS
... The aim of the present work was to develop a simple PK-PD model for NSAIDs taking dexibuprofen as a study drug. In this study, the pharmacokinetics and pharmacodynamics of dexibuprofen were ...
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Dose escalation study of octanoic acid in patients with essential tremor
... the PK approach. Comparison of the PK (concentration) and PD (effect) time profiles revealed a clear delay in the onset of the effect compared with plasma ...the PK/PD modeling, an ...
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Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers
... A PK/PD model illustrates that the relationship between mitiglinide concentration in plasma and glucose lower- ing effect in healthy Chinese volunteers was ...The PK data of mitiglinide after ...
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Pharmacokinetic Pharmacodynamic modeling of the analgesic effect of bupredermTM, in mice
... open model was used to explain the PK properties of BTDS, and the PD model was characterized by slow receptor ...developed PK-PD model, K d values ...
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Bundling arrows: improving translational CNS drug development by integrated PK/PD-metabolomics
... with PK/PD modeling has been shown in a few ...complex PK/PD model that described the gene-expression signaling cascade in the rat liver after corticosteroid treatment ...the ...
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A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model
... cellular PK/PD model, as well as provided a method for designing or optimizing prophylactic dos- age regimens for voriconazole in high-risk immunosup- pressed patients based on Monte Carlo simulation ...
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Mechanism-based model characterizing bidirectional interaction between PEGylated liposomal CKD-602 (S-CKD602) and monocytes in cancer patients
... based PK–PD model that incorporates the interaction between PEGylated liposomal anticancer agents and monocytes was developed for S-CKD602 (Figure ...one-compartment model and the PEGylated ...
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Population pharmacokinetics of methylphenidate hydrochloride extended-release multiple-layer beads in pediatric subjects with attention deficit hyperactivity disorder
... The PK and PD data used in this analysis were collected in separate studies, which is a ...the PK/PD ...pediatric PK model was adequate, differences may exist between the ...
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Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf
... Fig. 7. Cumulative population distributions of tulathromycin doses. Comparison of the two cumulative distributions of doses of tulathromycin, as predicted by a population PK/PD model for P. multocida ...
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Pharmacological modelling to investigate antimalarial drug treatment
... of PK/PD models to investigate antimalarial drug treatment has been limited to the eight accounts describe ...specific PK/PD model for antimalarial drugs and use it to investigate the ...
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Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects
... (PD) model for moxifloxacin, to evaluate the time course of its effect on QT intervals in ...for PK analysis. The PK-PD data obtained were analyzed using a nonlinear mixed-effects ...
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Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling
... compartment PK model, which was developed first to be subsequently linked to the PK/PD ...This model included drug elimination from the brain, confirming a previously developed PK ...
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Canalization effect in the coagulation cascade and the interindividual variability of oral anticoagulant response. a simulation Study
... One potential cause of the response variability that has not been generally considered is that due to the genetic polymorphism and phenotypical expression of the proteins that intervene in the coagulation cascade. Their ...
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Dosing regimen of meropenem for adults with severe burns : a population pharmacokinetic study with Monte Carlo simulations
... In this 80 context, dosage regimens can be optimised through integration of PK-PD targets, derived from 81 both PK data and exposure-response data, with Monte Carlo simulation to predict[r] ...
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A Review of Modeling Approaches to Predict Drug Response in Clinical Oncology
... PKPD model, developed based on leukocyte and neutrophil data ob- tained in patients after administration of docetaxel, paclitaxel, and etoposide, which was then applied to myelosuppression data obtained from ...
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Development and Validation of Pharmacokinetic (PK) and Pharmacodynamic (PD) models of certain new formulations.
... pharmacodynamic analysis of systemic effect of topically applied timolol maleate ophthalmic gelling vehicle. The objective of this study was to evaluate the degree of systemic absorption and the systemic side effect ...
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Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling
... of PK/PD breakpoints [8 – 11, 13 – 15, ...link PK parameters and variables with appro- priate indices of potency, applying the general equation for systemically acting drugs ...
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PK-PD modelling of the interaction of propofol and midazolam : implementation and future perspectives
... the PK-PD interaction between propofol and midazolam becomes clear in the clinical scenario displayed in figure ...pharmacodynamic model these plasma midazolam concentrations (still in disequilibrium ...
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