PLS-DA
Rapid high-throughput characterisation, classification and selection of recombinant mammalian cell line phenotypes using intact cell MALDI-ToF mass spectrometry fingerprinting and PLS-DA modelling
... Despite many advances in the generation of high producing recombinant mammalian cell lines over the last few decades, cell line selection and development is often slowed by the inability to predict a cell line ’ s ...
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Performance of Classification Analysis: A Comparative Study between PLS DA and Integrating PCA+LDA
... that PLS-DA highly recommend for a large sample size than PCA+LDA in dimension reduction and ...classification. PLS-DA can be considered to have a good and reliable technique to be used when ...
5
Identification of biomarkers of colitis to monitor effects of dietary omega 3 polyunsaturated fatty acids in the interleukin 10 gene deficient mouse model of inflammatory bowel diseases : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Nutritional Science at Massey University, Manawatū, New Zealand
... urine of mice fed the eicosapentaenoic acid EPA diet compared to those fed the oleic acid OA diet Partial Least Squares-Discriminant Analysis PLS-DA of metabolite fingerprint from urine [r] ...
21
Infrared spectroscopy coupled to cloud based data management as a tool to diagnose malaria: a pilot study in a malaria endemic country
... The ATR-FTIR spectroscopy-based diagnostic dem- onstrated excellent sensitivity and specificity against the PCR gold standard. The support vector machine learning algorithm performed better than the PLS-DA ...
11
Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage
... Sparse PLS-DA again demonstrated that our samples are sufficiently informative to classify healthy site plaque and disease site calculus based on microbial profile ...
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PLANT GROWTH MODELING OF ZINNIA ELEGANS JACQ USING FUZZY MAMDANI AND L SYSTEM APPROACH WITH MATHEMATICA
... (PLS- DA) is a discriminant analysis method based on partial least-squares ...Smart PLS-DA (sPLS-DA) was used to classify the three types of endometrial tissue samples based on the ...
10
Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats
... not include a drug effect component (i.e. DE = 0 in Eq. (5)). A ΔOFV significance threshold was calculated to be 16.00 for each single me- tabolite, taking into account the family wise error rate (FWER) using Bonferroni ...
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Atmospheric pressure chemical ionisation mass spectrometry analysis linked with chemometrics for food classification – a case study: geographical provenance and cultivar classification of monovarietal clarified apple juices
... the PLS-DA scores plots, very good clustering was observed for the monocultivar apple juices used in the present study, with juices extracted from Jazz apples showing the largest distance from Granny Smith, ...
8
Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer
... PCA, PLS-DA and Cox Regression for clinicopathological features and survival time to explore the significance of miRNA 106b~25 expression in plasma and cancer tissues for gastric ...Via PLS-DA ...
10
Integrative analysis of metabolome and gut microbiota in diet induced hyperlipidemic rats treated with berberine compounds
... 5′-phosphate; PLS-DA: partial least squares-discriminant analysis; RDP: ribosomal database project; RSB: resuspension buffer; SSAT: spermidine/ spermine-N 1 -acetyltransferase; TBA: total bile acid; TBIL: ...
13
Effects of dietary caprine milk oligosaccharides enriched fraction on maternal large intestine and the consequences for the development of the offspring : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy, Massey University, Palmerston North, New Zealand
... plot generated from mass spectrometry spectra of urine samples from dams treated with control (+), combo (x) and caprine milk oligosaccharides (∆) diet. Samples were run in two different columns HILIC and C18 and in both ...
25
Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B
... The spectral data were exported by Micromass Marker- Lynx ™ applications manager version 4.1 software (Waters Corporation, Milford, MA, USA). The raw data of each sample was normalized to total area to correct for the MS ...
8
Original Article Serum metabolic changes in rats after conventional external beam radiotherapy by gas chromatography-mass spectrometry
... Abstract: Conventional external beam radiotherapy has been widely used in various clinical malignant and pain management applications. In this study, we developed a serum metabolomic method based on gas chromatogra- ...
8
Identification of Pinus species related to historic architecture in Korea using NIR chemometric approaches
... discriminant models using wood block or tablet samples, these showed the correct prediction rate of 100 %. Using the tablet samples reduced the spectral differences of each species; however, it provided more specific ...
12
Protein differences between human trapezius and vastus lateralis muscles determined with a proteomic approach
... The vast number of protein spots detected in the 2D- DIGE analysis is evaluated statistically for their signifi- cant higher abundance in either muscle. Different statis- tical approaches can be used on this type of ...
11
Comparative Analysis of Three Torbangun Clones (Plectranthus amboinicus (Lour ) Spreng) Based on Phenotypic Characteristics and Phenolic Content
... When comparing both loading scatter plots (part B of Figure 3 and Figure 4), the 4 h-extraction method had more complex dots than the 2 h-extraction method. This occurred because in the 4 h-extraction method, the hy- ...
12
Original Article Serum metabonomic analysis of rats with cisplatin-induced nephrotoxicity and panax notoginseng saponins treatment
... filing approach. In this study, we found that serum BUN and Scr levels of rat significantly increased, and the renal tissues were damage after a single intraperitoneal injection of cis- platin [20, 21]. Moreover, PNS ...
11
Detection of Pseudomonas aeruginosa in sputum headspace through volatile organic compound analysis
... measurement. PLS- DA, a supervised technique, was used to discriminate between non-infected patients versus patients infected with ...the PLS-DA model ...and PLS-DA analyses were ...
9
Plasma, urine and ligament tissue metabolite profiling reveals potential biomarkers of ankylosing spondylitis using NMR based metabolic profiles
... 3 Partial least squares discriminant analysis PLS-DA score plots left panel and statistical validation of the corresponding PLS-DA model by permutation analysis right panel based on the [r] ...
13
Creatine-induced activation of antioxidative defence in myotube cultures revealed by explorative NMR-based metabonomics and proteomics
... and the authors ascribed the cytoprotective effect to scavenging dependent antioxidative mechanisms [38]. In the present study on murine myotubes, we revealed an additional antioxidant effect of creatine, i.e. its ...
10