Poly-L-glutamic acid
Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
... bifunctional nature resulting in its cross-linking capability [32]. Its bifunctional nature facilitates the formation of Schiff base [33], involving the direct reaction between aldehyde groups from glutaraldehyde with ...
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<p>In vivo Studies on Pharmacokinetics, Toxicity and Immunogenicity of Polyelectrolyte Nanocapsules Functionalized with Two Different Polymers: Poly-L-Glutamic Acid or PEG</p>
... Toxicity of potential nanotherapeutics is the most common cause that hinders their use in medicine, thus all possible adverse effects must be addressed during their thorough pre- clinical evaluation. First of all, the in ...
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Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes
... µ L PBS at 24 and 48 hours. The cell suspensions were mixed with 2 µ L mixed dyes reagent (v 1 /v 2 = 1), followed by staining for 2–3 minutes in the dark, and then they were recorded by the laser scanning ...
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Renal targeting potential of a polymeric drug carrier, poly-L-glutamic acid, in normal and diabetic rats
... kDa poly(vinylpyrrolidone-co- dimethyl maleic acid), and 19 kDa acetylated low-molecular- weight chitosan, have been suggested as potential carriers for renal targeting drug ...
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Synthesis, characterization, and biological evaluation of poly(L-γ-glutamyl-glutamine)-paclitaxel nanoconjugate
... water-soluble poly(L-γ-glutamyl-glutamine)-paclitaxel nanoconjugate (PGG-PTX) that would improve the therapeutic index of paclitaxel ...of poly(L-glutamic acid)- paclitaxel ...
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POLY GLUTAMIC ACID (PGA) – STRUCTURE, SYNTHESIS, GENOMIC ORGANIZATION AND ITS APPLICATION: A REVIEW
... Immobilization of cells has received a lot of attention in the production of various bio-products. The use of immobilized cells is very common for industrial application in order to reduce the costs of biopolymer ...
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In vitro removal of toxic heavy metals by poly(γ-glutamic acid)-coated superparamagnetic nanoparticles
... To determine the weight percentage of PGA coating on SPIONs, each sample weighing 5–15 mg was heated from 25 ° C–700 ° C in a versa Therm HS model Cahn thermogravi- metric analyzer (Thermo Fisher Scientific Inc, Waltham, ...
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Poly-l-gamma-glutamic acid production by recombinant Bacillus subtilis without pgsA gene
... produced l-PGA. Hence, l-PGA can be synthesized in the absence of PgsA, suggesting interactions between PgsA and racemase and/ or conformational changes induced by binding of PgsA to PgsBC complex (Sheng et ...
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Effect of poly-α, γ, L-glutamic acid as a capping agent on morphology and oxidative stress-dependent toxicity of silver nanoparticles
... and poly-α, γ, L-glutamic acid (PGA), a naturally occurring anionic polymer, was used as a capping agent to protect the silver nanoparticles from agglomeration and render them ...
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Poly (γ Glutamic Acid) Promotes Enhanced Dechlorination of p Chlorophenol by Fe Pd Nanoparticles
... (γ-glutamic acid) (PGA), a natural anionic poly- peptide produced by Bacillus subtilis, is nontoxic, highly water-soluble, and can be chemically, physically, and en- zymatically degraded in ...of ...
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Effect of glucose on poly-γ-glutamic acid metabolism in Bacillus licheniformis
... In this study, we demonstrated the effect of glucose on fermentation products through qualitative and quantita- tive analyses for the first time. The γ-PGA concentration decreased by 31.54 and 61.62% when the culture ...
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Microbial synthesis of poly-γ-glutamic acid: current progress, challenges, and future perspectives
... Oxygen is essential in aerobic fermentation and affects cell growth, carbon source utilization, biosynthesis of products, and NAD(P)H recycling [58]. Various strategies have been deployed to maintain oxygen supply, ...
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Rewiring glycerol metabolism for enhanced production of poly-γ-glutamic acid in Bacillus licheniformis
... Background: Poly-γ-glutamic acid (γ-PGA) is a natural polymer with great potential applications in areas of agricul- ture, industry, and pharmaceutical. The biodiesel-derived glycerol can be used as ...
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Isolation, Identification and Evaluation of Egyptian Bacillus sp. Isolates for Producing Poly-γ-glutamic Acid
... Based on the dry weight of PGA collected at the end of the incubation period of each grown Bacillus sp. isolates (assigned: B1 to B49), nine isolates (18%) revealed a high production of PGA ranged from 5 to 8 gl ...
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Key role of poly γ dl glutamic acid in immune evasion and virulence of Staphylococcus epidermidis
... acid by peak integration in comparison to pure D - and L -glutamic acid. Isolation of human polymorphonuclear leukocytes and phagocytosis experi- ments. Human polymorphonuclear leukocytes ...
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Study on the Stability of Poly glutamic Acid Fermentation Broth for Agricultural Use
... of poly-glutamic acid in five different viscosity fermentation broth, and the results were shown in ...of poly-glutamic acid and the molecular ...of poly-glutamic ...
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Bioactivity in silica/poly(γ glutamic acid) sol–gel hybrids through calcium chelation
... Calcium chloride has been used as a calcium source in several hybrids, including chitosan/GPTMS/silica [26], polyvinyl alcohol/ GPTMS/silica [27], c PGA/GPTMS/silica [28] and c PGA/APTES [21]. However, the calcium was ...
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Development and validation of a hptlc method for simultaneous estimation of L-glutamic acid and ?-aminobutyric acid in mice brain
... acid levels were increased and the levels of GABA were decreased in mice brains compared with control animals, with the continuous treatment of the PTZ indicating the induction of the epilepsy in the animals. The ...
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<p>Minimally Invasive Aesthetic Treatment of the Face and Neck Using Combinations of a PCL-Based Collagen Stimulator, PLLA/PLGA Suspension Sutures, and Cross-Linked Hyaluronic Acid</p>
... reshaping, and skin quality improvement. Three versions are available (Ellansé-S ® , -M ® ,-L ® ), providing the dura- tion of effect from at least 18 months up to 3 years (Table 2), 24,25 as the degradation time ...
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THE BILIARY EXCRETION OF SULFOBROMOPHTHALEIN SODIUM (BSP) IN THE RAT AS A CONJUGATE OF GLYCINE AND GLUTAMIC ACID
... identified as glycine and glutamic acid by the following: a The ninhydrin spots assumed the positions of glycine and glutamic acid on two-dimensional chromatography in phenol-NH3 and 80 [r] ...
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