Polygenic scores
Reconstructing the History of Polygenic Scores Using Coalescent Trees
... population-mean polygenic-score time courses under neutrality and that is also well powered to detect departures from neutrality (the proportion-of-lineages ...population-mean polygenic scores for ...
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Phenome-wide analysis of genome-wide polygenic scores
... Genome-wide polygenic scores (GPS), which aggregate the effects of thousands of DNA variants from genome-wide association studies (GWAS), have the potential to make genetic predictions for ...
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Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway
... a polygenic score based on identified risk variants within this genetic ...the polygenic score were tested for an epistatic component using a training set (n = 170), which was used to develop linear ...
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Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores
... on a different genotyping array, the OncoArray, than the Axiom UK Biobank Array used in this study [10]. To match published scores, GPS calculation included all variants regardless of imputation quality. We ...
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Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome wide association and polygenic scoring study
... use polygenic score analysis in cohorts of patients with mood disorders, to test for common genetic variants for mood disor- ders and suicide ...derived polygenic scores from each sample and tested ...
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Using DNA to Predict Educational Trajectories in Early Adulthood
... Our polygenic score estimates are substantially lower when compared to SNP and twin heritability estimates of educational ...phenotypes. Polygenic scores capture only a fraction of the known ...
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Polygenic risk score for predicting weight loss after bariatric surgery
... of polygenic risk scores on postsurgery weight loss was a multivariable linear mixed model that returned a more comprehensive value of the actual genetic effect on ...between polygenic risk ...
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Clinical Relevance of Genome-Wide Polygenic Score may Be Less than Claimed
... A recent study claimed that genome-wide polygenic scores (GPSs) for five common diseases could identify individuals with risk equivalent to monogenic mutations. Receiver operator curve analyses were ...
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Search | Preprints
... 36. Andersen, A. M.; Pietrzak, R. H.; Kranzler, H. R.; Ma, L.; Zhou, H.; Liu, X.; Kramer, J.; Kuperman, S.; Edenberg, H. J.; Nurnberger, J. I. J.; Rice, J. P.; Tischfield, J. A.; Goate, A.; Foroud, T. M.; Meyers, J. L.; ...
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Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5
... Several polygenic scores were created containing SNPs according to the significance of their association with the hip ...the polygenic profiles of hip osteoarthritis and DDH and the first two PCs were ...
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The Nature of Nurture: Using a Virtual-Parent Design to Test Parenting Effects on Children's Educational Attainment in Genotyped Families
... As an initial validity check, the independence of the non- transmitted and transmitted EA polygenic scores was ver- ified using a linear model. The association did not differ significantly from zero, β = ...
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Educational attainment and personality are genetically intertwined
... reflect polygenic influences that have been previously associated with educational ...Estonians, polygenic scores for educational attainment (EPS; interpretable as estimates of molecular genetic ...
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Personality Polygenes, Positive Affect, and Life Satisfaction
... in polygenic score prediction results from larger meta-analysis GWA studies of the predictor ...create polygenic personality scores that predicted major depressive disorder (from neuroticism) and ...
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Evidence for Recent Polygenic Selection on Educational Attainment and Underlying Cognitive Abilities Inferred from GWAS Hits: A Monte Carlo Simulation Using Random SNPs
... of polygenic selection can be identified by various methods, such as correlation of allele frequencies [1-4] and the regression of population average of trait values on polygenic scores (PS) [2,5-7], ...
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Assessing the incremental contribution of common genomic variants to melanoma risk prediction in two population-based studies
... of polygenic with traditional risk score tertiles estimated that 59% of people in Australia and 49% in Leeds have a genetic risk concordant with their traditionally estimated risk, a considerable proportion (9% ...
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Tread Lightly Interpreting Polygenic Tests of Selection
... on polygenic traits is developed and applied to sev- eral human examples (Racimo et ...in polygenic traits, and a challenge for evolutionary geneticists has been that these traits can evolve by small, ...
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Population specific factors associated with fractional excretion of uric acid
... in polygenic score modelling due to a high pro- portion of missing genotyping data for these ...for polygenic score ...weighted polygenic score for FEUA. A higher polygenic score indicates a ...
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Polygenic control of neuroinvasiveness in California serogroup bunyaviruses.
... Studies of the sequential spread of virus after subcutaneous inoculation of 103 PFU into suckling mice indicated that reassortants with no attenuated RNA segments replicated to a high ti[r] ...
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Polygenic in vivovalidation of cancer mutations using transposons
... We have shown here an efficient in vivo system for valid- ating cancer genes that uses standard molecular biology and transgenic techniques. Several systems for elegant for- ward and reverse genetic screens have been ...
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Genotype-environment interactions and the maintenance of polygenic variation.
... T h e expected value of 2, averaged across all environments (including both temporal and spatial components), will be assumed to be zero. Our definition differs from theirs o[r] ...
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