Poorly soluble drug
Enhancement of solubility and dissolution of poorly soluble drug: Ketoprofen as a model drug
... a poorly soluble drug Ketoprofen with the aid of Chitosan in presence of salting out ...predominated drug dissolution rate with the increasing concentrations of ...
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FORMULATION DEVELOPMENT OF MODEL FAST DISSOLVING ORAL FILM OF A POORLY SOLUBLE DRUG WITH IMPROVED DRUG LOADING USING MIXED SOLVENCY CONCEPT AND ITS EVALUATION
... On the basis of solubility studies, combinations of five solubilizer’s aqueous blends were selected for dissolving drug because of low individual toxicity of solubilizer and achieved desired required solubility of ...
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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF POORLY SOLUBLE DRUG ACECLOFENAC
... Preparation of fast dissolving tablets required quantity of solid dispersion (drug: polymer, 1:1 ratio) was weighed and sifted through #40 mesh and then taken in a polybag. Superdisintegrant via Crosspovidone and ...
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FORMULATION AND EVALUATION OF CLARITHROMYCIN POORLY SOLUBLE DRUG AS MICROEMULSION
... Dose of clarithromycin to be administered to rats was calculated according to body surface area ratio of rats to human being. Six week-old male Albino wistar rats which were cannulated with a silicone-polyethylene tube ...
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LIQUISOLID COMPCT: A NOVEL APPROCH TO ENHANCE BIOAVAILABILITY OF POORLY SOLUBLE DRUG
... the drug is in a solid dosage form, it is held within the powder substratein solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution ...
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A review on bio-availability enhancement techniques of poorly soluble drug
... It has been known for more than a century that supercritical fluids (SCFs) can dissolve non-volatile solvents, with the critical point of carbon dioxide, the most widely used supercritical fluid. Carbon dioxide is one of ...
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SOLUBILITY ENHANCEMENT STUDIES ON THE POORLY SOLUBLE DRUG FEBUXOSTAT
... The phase solubility studies were conducted by using a simple technique, which involves the addition of excess amount of FBX i.e. 100 mg in 25 ml of water containing different weights of solubilizing agents i.e. ...
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EFFECTS OF THE EUDRAGIT AND DRUG COAT ON THE RELEASE BEHAVIOUR OF POORLY SOLUBLE DRUG BY SOLID DISPERSION TECHNIQUE
... of poorly water-soluble ...a poorly water-soluble drug, furosemide, by solid dispersion technique as well as to evaluate the potential of Eudragit RL-100, RS-100 and Drug coat L ...
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A REVIEW ON HYDROTROPY: A POTENTIAL APPROACH FOR THE SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUG:
... The hydrotropy acts as increase in the solubility of solutes by the addition of high concentration of alkali metal salts of different organic acids. Which forward by Neuberg, there are several concentrated aqueous ...
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ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE DRUG – METRONIDAZOLE BY HYDROTROPY
... of drug & urea was 1:15 whereas secondly marked higher increase was found in Batch M3 (prepared by melting method) where the ratio of drug & urea was ...of poorly soluble drug ...
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FORMULATION AND OPTIMIZATION OF RUPTURABLE MEMBRANE COATED PULSATILE DRUG DELIVERY SYSTEM OF ZALTOPROFEN USING BOXBEHNKEN DESIGN
... pulsatile drug delivery system for poorly soluble drug, Zaltoprofen for bedtime dosing and pulsed release of drug to encounter symptoms of rheumatoid arthritis (RA) in the early ...of ...
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COMPEXATION OF POORLY WATER SOLUBLE DRUG WITH CYCLODEXTRIN
... of poorly soluble drug can be achieved in many ways, such as modification of drug crystal forms, addition of cosolvents, addition of surfactants, addition of cyclodextrins, ...
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IN VITRO STUDY OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF POORLY WATER SOLUBLE DRUG SPIRONOLACTONE
... of poorly soluble drug was study in different oils, surfactants and co- ...of drug in 2 ml of different oils (Castor oil, Soya bean oil, Arachise oil, Capmul oil, Micloyol oil, Oleic acid and ...
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Solubility Enhancement of Diacerein by Solid Dispersion Technique
... of drug and its therapeutic ...of drug substances in water (less than 1µg/ml) and their low dissolution rate in aqueous ...of poorly soluble drug among them solid dispersions is one of ...
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Formulation and Evaluation of Indomethacin Solid Dispersion by using Hydrophilic Polymers
... cumulative drug release 75% in 30 mins. Results of drug content and in vitro dissolution study indicated that that batch PEG (1:5) was having considerable content uniformity and desirable ...good ...
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"Enhancement of solubility of a poorly soluble antiplatelet aggregation drug by cogrinding technique"
... Results: The results showed that the presence of PVP in relatively high ratios compared to the drug is desirable for enhancing the dissolution rate of ticagrelor. The best-optimized formulae found were that F8 and ...
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Effect of Superdisintegrants Concentration on Dissolution Profile of Poorly Soluble Antiviral Drug
... The tablets were subjected to in-vitro dissolution profiling using Varian dissolution apparatus. The dissolution profiles of the Acyclovir-800mg tablets were determined using the paddle method (Varian) set with a paddle ...
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SOLID SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) DEVOLOPMENT, APPLICATIONS AND FUTURE PERSPECTIVE: A REVIEWFebi S Kuruvila*, Flowerlet Mathew ,S KuppuswamyDOWNLOAD/VIEW
... Construction of Pseudoternary Phase Diagram Pseudoternary phase diagram is important for determination of self nanoemulsifying drug delivery system (SNEDDS). It is diagrammatic representation of oil, surfactant ...
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SOLUBILITY ENHANCEMENT OF MELOXICAM BY LIQUISOLID TECHNIQUE AND ITS CHARACTERIZATION
... FTIR spectroscopy: Fourier-transform infrared (FTIR) spectra were obtained using an FTIR spectrometer (Shimadzu 8400S, Japan). The samples (Meloxicam and excipients) were previously ground and mixed thoroughly with ...
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GREEN SYNTHESIS OF NANOSILVER AND ITS EFFECT ON PHASE SOLUBILITY OF FEW BCS CLASS II DRUGS
... Metal nanoparticles are gaining much more importance and still there has been a remarkable research interest in the area of nanotechnology to develop reliable processes for the synthesis of metal nanoparticles[1] and ...
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