Population PK
Don't be afraid! Population PK-PD modeling as the basis for individualized dosing in children and critically ill
... and PK or PD model parameters, using fixed effects ...the PK and/or ...vs. population predictions, weighted residuals vs. time and population predic- tions ...
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The role of population PK-PD modelling in paediatric clinical research
... In order to characterise the specific influence of develop- mental changes in childhood on the PK of a drug, concentration–time profiles are necessary, which require measurements of drug concentrations. For ...
12
Mechanism-based model characterizing bidirectional interaction between PEGylated liposomal CKD-602 (S-CKD602) and monocytes in cancer patients
... affects PK of these agents. We developed mechanism-based PK–PD models based on direct and on indirect cytotoxicity of S-CKD602 to monocytes, and compared the model fit of these two ...mechanism-based ...
10
<p>Population pharmacokinetic analysis of tramadol and <em>O</em>-desmethyltramadol with genetic polymorphism of <em>CYP2D6</em></p>
... tramadol PK. In a previous study 20 that population PK modeling was developed with two-compartment model of both parent and metabolite, and the parameter such as CL/F and CLPM/F do not make much ...
11
Pharmacokinetic and exploratory exposure-response analysis of pertuzumab in patients with operable HER2-positive early breast cancer in the APHINITY study
... Global PK sub-study were compared with predictions based on a pre- viously developed pertuzumab population PK model ...for population PK devel- opment were based on pertuzumab without ...
12
Predicting tacrolimus concentrations in children receiving a heart transplant using a population pharmacokinetic model
... When guided by as few as three concentrations, the constructed population PK model successfully predicted an individual’s future tacrolimus concentrations with negligible bias and acceptable accuracy. The ...
8
Predicting the serum digoxin concentrations of infants in the neonatal intensive care unit through an artificial neural network
... a PK population using NON- MEM® software ...or PK parameters without drawing blood samples from new- born ...using population PK for digoxin concentrations in critically ill newborn ...
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Population Pharmacokinetics of Alemtuzumab (Campath) in Pediatric Hematopoietic Cell Transplantation: Towards Individualized Dosing to Improve Outcome
... predicting PK, indicating a higher maximal CL rate in patients harboring more targets for ...the population and treatment setting in the current study is significantly different, our parameter estimates in ...
12
Pooled post hoc analysis of population pharmacokinetics of oxycodone and acetaminophen following a single oral dose of biphasic immediate-release/extended-release oxycodone/acetaminophen tablets
... The influence of six different covariates (sex, race, age, weight, height, and BMI) on OC and APAP total body clearance (CL/F; F = bioavailability), volume of distribu- tion (V/F), and absorption rate constant (K a ) was ...
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CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe
... using population mixed effects non-linear regression modeling in NONMEM ...typical population PK parameters, along with their random inter-individual and inter-occasional (IO) variability was ...
10
Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf
... Fig. 7. Cumulative population distributions of tulathromycin doses. Comparison of the two cumulative distributions of doses of tulathromycin, as predicted by a population PK/PD model for P. multocida ...
40
On testing global optimization algorithms for space trajectory design
... Algorithm 1 GA 1: Set values for npop , GGAP , Cr , Mp and IN SR, set nf eval = 0 and k = 1 2: Initialize a population Pk of individuals xi,k for all i ∈ [1, ..., npop ] 3: Rank Pk accor[r] ...
25
Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous hemodiafiltration on different anticoagulant modalities
... of population PK facilitates the use of sparse data and also dense data, or even a combination of dense/sparse data to gain integrated information on ...gives population PK a great advantage ...
149
Population Pharmacokinetic/Pharmacodynamic Analysis of Nociceptive Pain Models Following an Oral Pregabalin Dose Administration to Healthy Subjects
... The PK of pregabalin was best described using a one- compartment model with linear elimination ...all population PK parameters, in order of inclusion: k a (ΔOFV = −96), lag time (ΔOFV = −22), CL ...
8
Pharmacokinetics and safety of ixazomib plus lenalidomide–dexamethasone in Asian patients with relapsed/refractory myeloma: a phase 1 study
... 28 % higher than East Asian RRMM patients on day 1 of dosing (194 [78 % CV] vs 152 [95 % CV] ng*h/ mL/mg, respectively) and 49 % higher on day 15 (401 [48 % CV] vs 269 [44 % CV] ng*h/mL/mg, respect- ively). However, ...
9
Selective use of sorafenib in the treatment of thyroid cancer
... ized, double-blind, placebo-controlled study (DECISION) analyzing the efficacy of a standard dose of sorafenib 800 mg in patients with RAI-refractory locally advanced or metastatic DTC. The population included 417 ...
13
On (p1,…,pk)-spherical distributions
... q > 0, introduced in Müller and Richter ( 2019 ) to a class of p -spherical processes, p =. ( p 1 , ..., p k ) ∈ ( 0, ∞ ) × k[r] ...
18
PubMedCentral-PMC5177463.pdf
... the PK of midazolam in critically ill children divided in different age groups: group 1, infants < 12 months (n = 16); group 2, children 1–2 years (n = 12); and group 3, children age 3 years and older (n = ...
32
DNA-PK Deficiency in Alzheimer's Disease
... AD: Alzheimer’s disease; ATM: Ataxia telangiectasia mutated protein; BER: base excision repair; DNA-PK: DNA- dependent protein kinase; DSB: double strand breaks; DSBR: Double strand break repair; HR: Homologous ...
6
Observation of the Decay Ξb- →pK-K-
... → pK − K − is observed with a significance of ...→ pK − π − ...→ pK − π − and Ξ − b → pπ − π − relative to Ξ − b → pK − K − decays are also ...
11