programmed cell death 1 ligand 1
The expression status and prognostic significance of programmed cell death 1 ligand 1 in gastro­intestinal tract cancer: a systematic review and meta-analysis
... Background: Programmed cell death 1 ligand 1 (PD-L1) expression has been observed in various malignancies. However, the association between PD-L1 expression and the survival of ...
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A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients
... OR programmed cell death 1 ligand 1 OR CD274) AND (melanoma OR malignant mela- noma) AND (survival OR prognostic OR prognosis OR ...
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CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma
... CXC ligand 1; RFS: Recurrence-free survival; OS: Overall survival; PD-L1: Programmed cell death 1 ligand 1; Treg: Regulatory T; MMP9: Matrix metalloproteinase 9; ...
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Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer
... This meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Anal- yses (PRISMA) Statement [16]. Relevant studies were searched from online databases PubMed, EMBASE, Web of ...
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CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
... PD-1: Programmed cell death receptor-1; PD-L1: Programmed cell death ligand-1; NSCLC: Non- small-cell lung cancer; ADC: Adenocarcinoma; SCC: ...
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Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma
... The relationship between PD-L1 expression and patients’ response rate to anti-PD-1/PD-L1 immuno- therapy was also not clear [27]. In the phase 1b KEY- NOTE-012 study of 39 patients, pembrolizumab showed promising ...
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Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy
... grammed cell death protein 1 (PD-1). PD-1 is expressed by T cells and interacts with its ligands programmed cell death protein ligand 1 (PD-L1) and ...
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<p>Immunological nomograms predicting prognosis and guiding adjuvant chemotherapy in stage II colorectal cancer</p>
... PD-1, programmed cell death 1 protein; PD-L1, programmed death-ligand 1 protein; NGS, next-generation sequencing; TMA, tissue microarray; RFS, relapse-free ...
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Programmed death-ligand 1 is upregulated in intrahepatic lymphoepithelioma-like cholangiocarcinoma
... 7 (CK7) (Clone OV-TL 12/30, Dako A/S, Denmark), anti-cytokeratin 19 (CK19) (Clone RCK108, Dako A/S, Denmark) and anti-PD-L1 (Clone SP263, Ventana, Tucson, AZ, USA). Omission of primary antibody and substitution by ...
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<p>BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes</p>
... small- cell lung cancer (NSCLC), which accounts for 80% of lung cancers, and most are diagnosed at an advanced ...stage. 1 The curative ability of traditional treatment — radiotherapy and chemotherapy — is ...
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The Expression of Programmed Death Ligand-1 within Stages of Oral Squamous Cell Carcinoma: Immunohistochemical Analysis
... (n=37). Programmed Death Ligand-1 positivity was observed in ...of Programmed Death Ligand-1 with stage II and IV ...of Programmed Death ...
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The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody has a good effect in the treatment of non-small cell lung cancer ...
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Upregulation of programmed death 1 on T cells and programmed death ligand 1 on monocytes in septic shock patients
... Monocytes play an essential role in the innate immune defense against microbial infection. Septic immunopara- lysis is first characterized by a monocytic deactivation of phagocytic function, proinflammatory cytokine ...
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Intralymphatic histiocytosis in a patient with lung adenocarcinoma treated with pembrolizumab: a case report
... non-small- cell lung cancer (NSCLC) [1, 2]. Pembrolizumab, an anti-programmed death (PD-1) antibody, has shown favorable antitumor efficacy in NSCLC patients [1, ...of ...
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<p>Use of Programmed Death Receptor-1 and/or Programmed Death Ligand 1 Inhibitors for the Treatment of Brain Metastasis of Lung Cancer</p>
... Several studies have shown that PD-1 inhibitor coupled with CTLA-4 inhibitor has a more effective treatment outcome on brain metastasis of NSCLC. Since the dual immune blocking mode was approved by the FDA for ...
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The effect of chemotherapy on programmed cell death 1/ programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response
... agents tested in the study had similar effects on PD-L1 surface expression in breast cancer cells [18], suggesting that they may act through a common pathway (Figure 3). IFN-γ enhances cancer immunoresistance by ...
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A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced Intestinal Dysfunction
... protein programmed death-1 (PD-1 or CD279) and its ligand PD-L1 (B7-H1 or CD274) have been reported to be important in the regulation of immune function in animals and patients with ...
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Original Article Programmed death-1 and PD-1 ligand-1 expression in early onset gastric carcinoma and correlation with clinicopathological characteristics
... We also collected tumor clinicopathological features such as tumor site, size, Borrmann type [24], WHO histological classification [24], Lauren’s histological type [25], invasion depth, lymph node metastasis, vein ...
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Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives
... immune cell-based vac- cination ...as programmed cell death 1 (PD-1), pro- grammed cell death 1 ligand 1 (PD-L1) and cytotoxic ...
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Molecular imaging biomarkers for cell based immunotherapies
... PD‑L1: programmed cell death‑ligand 1; CTLA4: cytotoxic T‑lymphocyte‑associated antigen 4; PDCD1/PD1: pro‑ grammed cell death protein‑1; FDA: Food and Drug ...
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