programmed cell death ligand 1
Hyperprogression after anti-programmed cell death ligand-1 therapy in a patient with recurrent metastatic urothelial bladder carcinoma following first-line cisplatin-based chemotherapy: a case report
... results indicated urothelial carcinoma. The patient was started on PD-L1 blockade monotherapy on December 19, 2017. Chest radiography and a full-body CT on January 15, 2018 showed pronounced enlargement of a left lung ...
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Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis
... T cell exhaustion [3]. T cell exhaustion was first described in states of chronic viral infection with persistent high levels of antigen exposure ...cytotoxic cell death in targeted cells ...T ...
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Immune checkpoint therapy in liver cancer
... (CTLA-4), programmed cell death protein-1 (PD-1), and programmed cell death ligand 1 (PD-L1), have been identified to suppress anti-tumor immune ...
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CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
... PD-1: Programmed cell death receptor-1; PD-L1: Programmed cell death ligand-1; NSCLC: Non- small-cell lung cancer; ADC: Adenocarcinoma; SCC: ...
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Molecular imaging biomarkers for cell based immunotherapies
... Effective anti-cancer treatments are largely affected by the cross-talk between cancer and the patient’s immune system. Studies have demonstrated that tumors evade the host immune response via a number of mechanisms ...
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Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer
... This meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Anal- yses (PRISMA) Statement [16]. Relevant studies were searched from online databases PubMed, EMBASE, Web of ...
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Original Article Programmed death-1 and PD-1 ligand-1 expression in early onset gastric carcinoma and correlation with clinicopathological characteristics
... on cell numbers and expression intensi- ...EOGC cell molecular phenotypes such as cell adhesion molecules, E-cadherin, and mucin differ from those of GC-E ...
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Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy
... grammed cell death protein 1 (PD-1). PD-1 is expressed by T cells and interacts with its ligands programmed cell death protein ligand 1 (PD-L1) and ...
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A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced Intestinal Dysfunction
... Accumulating evidence has demon- strated that the PD-1/PD-L1 pathway plays an important role in regulating the immune-inflammatory response during sepsis, as sepsis can upregulate PD-L1 expression on a variety of ...
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<p>Immunological nomograms predicting prognosis and guiding adjuvant chemotherapy in stage II colorectal cancer</p>
... PD-1, programmed cell death 1 protein; PD-L1, programmed death-ligand 1 protein; NGS, next-generation sequencing; TMA, tissue microarray; RFS, relapse-free ...
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<p>BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes</p>
... small- cell lung cancer (NSCLC), which accounts for 80% of lung cancers, and most are diagnosed at an advanced ...stage. 1 The curative ability of traditional treatment — radiotherapy and chemotherapy — is ...
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The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody has a good effect in the treatment of non-small cell lung cancer ...
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Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma
... ing, 1 for weak staining, 2 for moderate staining, and 3 for strong ...scored 1, 26%–50% scored 2, 51%–75% scored 3, and 76%–100% scored 4 ...− 1) were used to determine the optimal cut-off score of ...
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The effect of chemotherapy on programmed cell death 1/ programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response
... agents tested in the study had similar effects on PD-L1 surface expression in breast cancer cells [18], suggesting that they may act through a common pathway (Figure 3). IFN-γ enhances cancer immunoresistance by ...
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Upregulation of programmed death 1 on T cells and programmed death ligand 1 on monocytes in septic shock patients
... Induction of T-cell apoptosis and PD-L1 blockade in vitro PBMCs were separated from whole blood of septic patients using standard gradient centrifugation with Lym- phocyte Separation Medium (PAA Laboratories GmbH, ...
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Intralymphatic histiocytosis in a patient with lung adenocarcinoma treated with pembrolizumab: a case report
... non-small- cell lung cancer (NSCLC) [1, 2]. Pembrolizumab, an anti-programmed death (PD-1) antibody, has shown favorable antitumor efficacy in NSCLC patients [1, ...of ...
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<p>Prognostic and clinicopathological value of PD-L1 in colorectal cancer: a systematic review and meta-analysis</p>
... specially programmed death 1 (PD-1) and programmed death ligand-1 ...T cell proliferation, resulting in tumor immune evasion. 17 PD-1/PD-L1 immune ...
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<p>Use of Programmed Death Receptor-1 and/or Programmed Death Ligand 1 Inhibitors for the Treatment of Brain Metastasis of Lung Cancer</p>
... of programmed death receptor-1/programmed death ligand 1 (PD-1/PD-L1) can stimulate surrounding T cells and thus have antitumor effects in the ...non-small ...
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A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients
... OR programmed cell death 1 ligand 1 OR CD274) AND (melanoma OR malignant mela- noma) AND (survival OR prognostic OR prognosis OR ...
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Original Article PD-L1 blockade improves immune dysfunction of spleen dendritic cells and T-cells in zymosan-induced multiple organs dysfunction syndromes
... and programmed death ligand 1 (PD-L1) were expressed on T-cell, B-cell, DC and ...co-inhibitor, programmed death 1 (PD-1) was mainly expressed on the ...
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