Programmed death-1
Upregulation of programmed death 1 on T cells and programmed death ligand 1 on monocytes in septic shock patients
... Sepsis produces marked alterations in the expression of membrane-associated co-stimulatory/inhibitory molecules. Expression of these accessory molecules appears to contri- bute to the morbidity/mortality seen not only in ...
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Programmed death 1 blockade, an Achilles heel for MMR-deficient tumors?
... In summary, enhanced efficacies without systemic tox- icities are the primary goals of anti-cancer therapy including immunotherapy. Major therapeutic gains have been made in a wide variety of solid tumors by blocking ...
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Original Article Programmed death-1 and PD-1 ligand-1 expression in early onset gastric carcinoma and correlation with clinicopathological characteristics
... Abstract: Purpose: Early onset gastric carcinoma (EOGC) is thought to be developed by a distinct molecular genetic profile of gastric carcinoma occurring at an older age. The aim of this study was to compare ...
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Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor
... The designed model of peptide Ar5Y_4 in complex with hPD-1 served as the initial structure for MD simulation using AMBER14 [47]. The complex was solvated by TIP3P explicit waters [48] and counter ions were added ...
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Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma
... ing, 1 for weak staining, 2 for moderate staining, and 3 for strong ...scored 1, 26%–50% scored 2, 51%–75% scored 3, and 76%–100% scored 4 ...− 1) were used to determine the optimal cut-off score of ...
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Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway
... Abstract: T-lymphocytes have the potential to recognize cancer antigens as foreign and therefore eliminate them. However, immune checkpoints such as cytotoxic T-lymphocyte- associated antigen (CTLA)-4 and ...
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A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients
... In recent years, immune inhibitory signaling path- ways have been recognized to play a pivotal role in the maintenance of an immunosuppressive microen- vironment that favors cancer development [13]. One important ...
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Wnt/beta-catenin pathway: modulating anticancer immune response
... Anti- programmed death-1; anti-PD-L1: Anti-programmed death ligand-1; APC: Adenomatous polyposis coli; CBP: cAMP response element-binding (CREB)-binding protein; COX-2: ...
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The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody has a good effect in the treatment of non-small cell lung cancer (NSCLC), but not all ...
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Original Article PD-L1 blockade improves immune dysfunction of spleen dendritic cells and T-cells in zymosan-induced multiple organs dysfunction syndromes
... and programmed death ligand 1 (PD-L1) were expressed on T-cell, B-cell, DC and ...co-inhibitor, programmed death 1 (PD-1) was mainly expressed on the surface of activated ...
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<p>BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes</p>
... stage. 1 The curative ability of traditional treatment — radiotherapy and chemotherapy — is limited, and it is not easily accepted by patients due to its high toxicity and adverse ...block programmed ...
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Programmed death-ligand 1 is upregulated in intrahepatic lymphoepithelioma-like cholangiocarcinoma
... Intrahepatic lymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare variant of cholangiocarcinoma. Here, we report the largest single series of LELCC cases yet studied (n = 13). We retrospectively analyzed the ...
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Sick sinus syndrome associated with anti-programmed cell death-1
... including cardiac enzyme, electrolytes and thyroid function were all within a normal range. Simultaneously, he complained of fatigue, dizziness and anorexia with hypotension. Lab data revealed low cortisol and ACTH ...
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Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy
... cell death protein 1 (PD-1). PD-1 is expressed by T cells and interacts with its ligands programmed cell death protein ligand 1 (PD-L1) and programmed cell ...
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The effect of chemotherapy on programmed cell death 1/ programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response
... (Table 1). PD-1 and PD-L1 antibodies have shown considerable clinical efficacy and durability across a range of malignancy subtypes, including melanoma and lung cancer [9, 58] and most recently in ...
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CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
... cell death receptor-1 (PD-1) and its ligand (PD-L1) have shown promising antitumor effects in various cancers, including non-small-cell lung cancer (NSCLC) ...
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Programmed cell death in the skin
... The programmed cell death or terminal differentiation program occurring to keratinocytes is referred to as cornification and it is distinguished from canonical apoptosis both morphologically than ...
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Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma
... Ewing sarcoma (EWS) is a poorly differentiated, aggressive malignant small blue round cell tumour of the bone and soft tissue [1]. It accounts for 34 % of primary bone tumours in people <20 years with an ...
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Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype
... Microglia/macrophages effectively regulate restoration and regeneration of the CNS. However, these molecules can act as double-edged swords, resulting in both de- struction and restoration [31]. Further studies have dem- ...
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Lineage specific cell death in postembryonic brain development of Drosophila
... regulating programmed cell death in these lineages? For the PC lineage, there is some indication that the total clone size is reduced by approximately half in en loss-of-function mutants, compared with wild ...
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