Programmed death-ligand 1 (PD-L1)
Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors
... and programmed cell death 1 (PD-1)/ programmed death ligand-1 (PD-L1)—unleash tumor- specific immune responses and are now FDA-approved to ...
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The Expression of Programmed Death Ligand-1 within Stages of Oral Squamous Cell Carcinoma: Immunohistochemical Analysis
... (n=37). Programmed Death Ligand-1 positivity was observed in ...of Programmed Death Ligand-1 with stage II and IV ...of Programmed Death ...
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Upregulation of programmed death 1 on T cells and programmed death ligand 1 on monocytes in septic shock patients
... [17,18]. Programmed death-1 (PD-1) is a newly iden- tified co-inhibitory ...receptor. PD-1 has two main ligands – PD-L1 (B7-H1) and PD-L2 (B7-DC) ...
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Programmed death-ligand 1 (PD-L1) is expressed in a significant number of the uterine cervical carcinomas
... anti-human PD-L1 monoclonal antibody (clone SP142) was obtained from Spring Bioscience (Pleasan- ton, CA) ...a 1:100 di- lution, adhering to the general guidelines recommended by the Spring ...
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Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)
... and PD-L2 demonstrated that both BMS-8 and BMS-202 are specific for ...human PD-L2 (hPD-L2) is available to date and only murine PD- L2 (mPD-L2) extracellular domain was crystallized in an apo form ...
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<p>Immunological nomograms predicting prognosis and guiding adjuvant chemotherapy in stage II colorectal cancer</p>
... T-helper 1 and cytotoxicity- related genes and helped predict tumor recurrence and ...the programmed cell death 1 protein (PD-1) and the programmed ...
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Original Article PD-L1 blockade improves immune dysfunction of spleen dendritic cells and T-cells in zymosan-induced multiple organs dysfunction syndromes
... CD86, programmed death (PD-1), programmed death ligand 1 (PD-L1), paired immunoglobulin-like receptor B (PIR-B) or T-cell proliferation in serum, ...
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A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients
... the programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1) axis ...[14]. PD-1 is expressed in a wide range of immune ...
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<p>Prognostic and clinicopathological value of PD-L1 in colorectal cancer: a systematic review and meta-analysis</p>
... specially programmed death 1 (PD-1) and programmed death ligand-1 ...of PD-L1 with its receptor PD-1 on T cells delivers a signal ...
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<p>BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes</p>
... stage. 1 The curative ability of traditional treatment — radiotherapy and chemotherapy — is limited, and it is not easily accepted by patients due to its high toxicity and adverse ...block programmed ...
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The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody has a good effect in the treatment of non-small cell lung ...
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Intralymphatic histiocytosis in a patient with lung adenocarcinoma treated with pembrolizumab: a case report
... anti-programmed death (PD-1) antibody, has shown favorable antitumor efficacy in NSCLC patients [1, ...of programmed death ligand 1 (PD-L1) ...
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Original Article Programmed death-1 and PD-1 ligand-1 expression in early onset gastric carcinoma and correlation with clinicopathological characteristics
... in PD-L1 and PD-1 expression between EOGC and ...of PD-L1 expression ...positive PD-L1 expression ...of PD-L1 and PD-1 expression in ...
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Near complete response after single dose of nivolumab in patient with advanced heavily pre-treated KRAS mutant pulmonary adenocarcinoma
... Programmed death 1 (PD-1) receptor is an inhibi- tory T cell receptor expressed by activated T-cells and engaged by ligands PD-L1 and PD-L2 of the B7-ligand ...
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PD-1/PD-L1 blockades in non-small-cell lung cancer therapy
... cancer death in males and the second leading cause of death in females ...of programmed death-1 (PD-1) receptor and its ligand PD-L1, achieved robust ...
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Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives
... as programmed cell death 1 (PD-1), pro- grammed cell death 1 ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated antigen-4 (CTLA4), resulted ...
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CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
... B; PD-1: Programmed cell death receptor-1; PD-L1: Programmed cell death ligand-1; NSCLC: Non- small-cell lung cancer; ADC: Adenocarcinoma; SCC: ...
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Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy
... cell death protein 1 (PD-1). PD-1 is expressed by T cells and interacts with its ligands programmed cell death protein ligand 1 (PD-L1) ...
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Hyperprogression after anti-programmed cell death ligand-1 therapy in a patient with recurrent metastatic urothelial bladder carcinoma following first-line cisplatin-based chemotherapy: a case report
... revealed PD-L1 expression in up to a quarter of RC tumor cells and up to a tenth of tumor-infiltrating immune cells, which suggests that PD-L1 immunopositivity is not a reliable indicator of ...
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The frequency of high PD-L1 expression is low in lung adenocarcinoma patients from Northeast Brazil
... of programmed cell death – ligand 1 (PD-L1) has been associated with good clinical response of ICPIs in lung adenocarcinoma where the rate of high PD-L1 expression ...
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