Protein aggregation, autophagy and mitochondrial dysfunction
Autophagy flux induced by ginsenoside-Rg3 attenuates human prion protein-mediated neurotoxicity and mitochondrial dysfunction
... prion-induced mitochondrial dysfunction and neurotoxicity via autophagy ...used autophagy inhibitors, 3-methyladenine (3-MA) and wortmannin, and small interfering RNA (siRNA) tools to study ...
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Herp depletion protects from protein aggregation by up-regulating autophagy
... Protein aggregation Beclin-1 Herp is an endoplasmic reticulum (ER) stress inducible protein that participates in the ER-associated protein degradation (ERAD) ...other protein ...
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Original Article Chloroquine sensitizes hepatocellular carcinoma cells to chemotherapy via blocking autophagy and promoting mitochondrial dysfunction
... an autophagy inhibitor, as a novel antitumor ...the autophagy and on the sensitivity of hepato- cellular carcinoma cells in ...the autophagy induction by cis- platin in hepatocellular carcinoma HepG2 ...
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Mitochondrial degradation by autophagy (mitophagy) in hepatocytes
... present in mitochondria to protect mtDNA and because DNA repair mechanisms in mitochondria are less robust than in the nucleus (Yakes and Van, 1997; Bohr, 2002). Moreover, virtually all mtDNA is transcriptionally active ...
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Mitochondrial dysfunction in Parkinson’s disease
... that dysfunction of mitochondria may play key roles in DA neuronal ...to mitochondrial dysfunction and PD ...inhibit mitochondrial complex I provides direct evidence linking ...
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Mitochondrial dysfunction in the pathogenesis of neurodegeneration
... of mitochondrial dysfunction in a number of neurodegenerative ...studies mitochondrial dysfunction, and the role of reactive oxygen species, nitric oxide and excitotoxicity in the pathogenesis ...
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Dysregulation of autophagy and mitochondrial function in Parkinson’s disease
... opinion, autophagy activity and mitochondrial homeostasis are of high importance in the pathogenesis of ...between autophagy and mitochondria function can give rise to novel therapeutic methods for ...
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The role of mitochondrial dysfunction in acute pancreatitis
... Ashland, MA) and allowed to attach for 30 mins at room temperature in the dark. The media was exchanged to remove unattached cells and to introduce the long term culture media described previously. Cells were exposed to ...
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Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX
... to mitochondrial dysfunction and cell ...defective mitochondrial quality control, which in turn leads to mitochondrial dys- function and cell ...
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Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction
... 3.9.3 Mitophagy inhibition prevents aSyn-associated reduction in mtGFP signal The interplay between aSyn and mitophagy remains unresolved, with some studies suggesting that mitophagy is protective, while others suggest ...
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Unravelling the role of mitochondrial dysfunction in core myopathies
... smaller mitochondrial populations, which would correspond with the presence of cores (though I found no visual evidence of cores or mitochondrial displacement in the HET ...in mitochondrial number ...
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Evaluation of Mitochondrial Dysfunction and α-Synuclein Aggregation in Yeast Models of Parkinson’s Disease
... terminus (only 2; Kessler et al., 2003; Uversky et al., 2002). These regions are found to inhibit the toxic conversion to a β-sheet-rich conformation and thus prevent fibrillization and aggregation. Yet, familial ...
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Mitochondrial dysfunction in human pathologies
... The tri-peptide glutathione (g-glutamyl-cyteinyl- glycine) is an endogenous antioxidant of great importance. GSH is required for the maintenance of the thiol redox status of the cell, protection against oxidative damage, ...
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Mitochondrial dysfunction in diabetic cardiomyopathy
... that mitochondrial ROS activate multiple pathways for cellular damage in the setting of hyperglycemia [89 – ...cardiac mitochondrial proteins in mice with Type 1 diabetes ...antioxidant protein, in ...
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Investigating the pathogenesis of mitochondrial dysfunction in mitochondrial and other myopathies
... pathological protein aggregates and mitochondrial dysfunction, found here, are very different to previous findings in sporadic inclusion body myositis ...with mitochondrial respiratory chain ...
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Megakaryocytic dysfunction in immune thrombocytopenia is linked to autophagy
... of autophagy in megakaryopoiesis, thrombopoiesis, and platelet function have been revealed in patients with thrombocytopenic disorders, insights into signalling pathways may guide future research in this ...
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Polycystic ovary syndrome and mitochondrial dysfunction
... Apoptosis is related to reduced follicular atresia, which is the mechanism underlying abnormal ovulation in PCOS. This study verified that the decrease in some apoptotic markers and increase in OS may interact in the ...
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Mitochondrial Dysfunction in Lyssavirus-Induced Apoptosis
... Matrix protein forms an in vivo complex with subunit I of the ...the mitochondrial ge- netic code and within the context of the two-hybrid assay, the CcO1 insert encodes a very small fragment corresponding ...
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Mitochondrial dysfunction associated with glucocerebrosidase deficiency
... Aberrant protein handling of α-synuclein by the ALP occurs in both GD and ...PD. Mitochondrial dysfunction is also observed in both GD and ...mitochondria dysfunction will also be discussed, ...
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Mitochondrial dysfunction in pathophysiology of heart failure
... for mitochondrial dys- function is the balance of NAD + /NADH redox, which regulates substrate oxidation, NAD + -dependent protein deacetylation, and mitochondria-initiated inflammatory ...of ...
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