Ras mutant
Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth
... To evaluate the inhibitory effect of inRas37 on RAS downstream sig- naling, various cells (10 5 cells per well) were seeded in 24-well ultralow attachment plates (Corning) in media containing 10% FBS. The cells ...
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Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression
... Additional file 1: Table S1 Primer sequences used for qRT-PCR. Figure S1 Expression of K-Ras in NSCLC cells that overexpressed or silenced K- Ras. a shRNA of K-Ras significantly suppressed ...
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Allosteric MEK1/2 Inhibitors for the Treatment of Cancer: an Overview
... (B-RAF mutant and B-RAF wild-type), NSCLC (K-RAS mutant), and CRC (K-RAS mutant) was also recently published and concluded that CH4987655 showed early signs of activity in the melanoma ...
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Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy
... and RAS signaling molecules are major drivers [11, 51, ...by RAS/ERK, but promoted by RAS/AKT in the selected ovarian cancer cell model, which are inconsistent with previous reports [53, ...of ...
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Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytes
... of RAS activity has not met with great success [62], but targeting of downstream signalling molecules (such as RAF and MEK) holds promise ...to RAS mutant cells ...the RAS signalling pathway. ...
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H-Ras and Its Oncogenic Mutants Ras G12V and Ras Q61L
... H-Ras mutant in glycerol with Tyrosine ...the mutant H-Ras in glycerol and the mutant in H-Ras in aqueous solution structures is ...between mutant H-Ras in glycerol ...
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EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition
... On the contrary, our results seem to suggest a putative negative predictive significance of K-Ras mutations for anti- EGFR TKI activity. None of the patients with K-Ras mutant tumor achieved an ...
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Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras
... Although Ras is known to signal through multiple pathways, the PI3K and MAPK pathways are the most studied and compounds targeting these pathways are in clinical development ...in Ras mutant cancers ...
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Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer.
... including RAS small GTPases and the RAF-MEK-ERK and phosphoinositide 3-kinase (PI3K)-AKT ...pathways. RAS is critical for the activation of the RAF pathway and also contributes directly to activation of the ...
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Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras
... Oncogenic Ras increases the rate of glycolysis and stimulates the pentose phosphate pathway (PPP) and the hexosamine biosynthesis pathway (HBP), thereby promoting efficient macromolecule synthesis and rapid ...
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Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells
... of mutant BRAF [64], PI3K upregulation [23], EGFR activation [54] or mutations in the allosteric pocket of MEK, which can directly block the inhibitor binding to the MEK kinase or induce constitutive MEK kinase ...
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PubMedCentral-PMC4846854.pdf
... in RAS mutant-driven mouse models of cancer ...of mutant KRAS in pancreatic cancer cells reduced proliferation, anchorage-independent growth, and tumorigenic growth ...KRAS mutant PDAC [36]; ...
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Casein kinase 1α–dependent feedback loop controls autophagy in RAS driven cancers
... status. Cells were treated with 4-OHT for 48 hours. endo, endogenous. (B) CK1α depletion further upregulates LC3B-II. Eight hours after siRNA transfec- tion, 4-OHT was added to cells for an additional 72 hours. (C) CK1α ...
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Quantitative Analysis of Ras Oncogene Isoforms Using Decision Tree and Support Vector Machine
... Abstract: Ras isoform plays a significant functional role in cell growth, cell cycle progression, cytoskeletal changes, apoptosis, and ...Mutated Ras gene causes cell ...mutated Ras is oncogenic. ...
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Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation
... RASA1 (RAS p21 protein activator (GTPase activating protein)), also called p120RasGAP, is the first identified RasGAP protein. In addition to the RasGAP domain, RASA1 contains 2 SH2 (Src homology 2) domains, a SH3 ...
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WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
... destabilizes RAS in HCC [19], so we examined whether Wdr76 regulates Ras stability in the small intes- ...restricts Ras abundance by regu- lating the stability of the Ras ...of Ras ...
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Gankyrin plays an essential role in Ras induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells
... blocks Ras-induced transformation and ...in Ras-transformed NIH3T3 cells stably expressing Gankyrin shRNA or a scramble control ...of Ras G12V–transformed NIH3T3 cells to form tumors in the nude mice ...
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The role of epithelial–mesenchymal transition programming in invasion and metastasis: a clinical perspective
... studies, we have made use of a mouse model of human lung adenocarcinoma, driven by mutant K-ras and Tp53 , where the tumors metastasize to sites commonly involved in lung cancer pa[r] ...
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Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap
... vap mutant larvae, there is, already after 1 h of heat shock, a stronger increase of MAPK activation, and the level of activation is overall higher than in wild ...
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An NF κB pathway–mediated positive feedback loop amplifies Ras activity to pathological levels in mice
... of Ras activity are critical for Ras-induced ...of Ras activity are ...oncogenic Ras, inflammatory stimuli initiate a positive feedback loop involving NF-kB that further amplifies Ras ...
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