RAS mutations
Prognostic significance of K ras mutations in pancreatic cancer: a meta analysis
... K-ras mutations in circulating DNA, which can be performed before and after operation, is much more convenient than the application of tissue ...K-ras mutations in the peripheral blood might ...
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The prognostic impact of K-RAS mutations in adult acute myeloid leukemia patients treated with high-dose cytarabine
... Eighty-nine consecutive patients with de novo AML attend- ing the Hematology and Oncology Unit, Zagazig University Hospital, Egypt were enrolled in this study cohort for the biologic and prognostic impact of RAS ...
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EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition
... K-Ras mutations for anti- EGFR TKI activity. None of the patients with K-Ras mutant tumor achieved an objective response with salvage erlotinib and these patients experienced a significantly worse ...
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The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention?
... NRAS mutations (RASmut) are recurrent within patients with MLL-r, with 58 MLL-AF4+ B-cell precursor ALL (BCP-ALL) being the most targeted ...the RAS signalling pathway offers an alternative 60 therapeutic ...
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Quantitative Analysis of Ras Oncogene Isoforms Using Decision Tree and Support Vector Machine
... H-Ras mutations have been reported in melanoma, bladder, thyroid, and mammary carcinoma; it has been reported that the H-Ras oncogene exhibits consistently greater transforming ability than oncogenic ...
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Review Article Molecular markers prognosticate the aggressiveness of papillary thyroid cancer
... human RAS genes includes HRAS, KRAS, and NRAS genes. Point mutations in 1 of the 3 RAS genes are currently the second-most common genetic alteration in thyroid cancer ...Although RAS is a ...
11
jcs.182873.full.pdf
... of RAS have focused on HRAS (Vetter, ...mutated RAS isoform in human cancers (4%), whereas KRAS is the predominantly mutated isoform (85%), followed by NRAS ...oncogenic RAS when defining the ...
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Differences in K-rasand mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients
... the mutations involve a single amino acid submission at codon 12 or 13, which decreases the intrinsic guanosine triphosphatase activity and which leads to the constitutive activation of the K-ras signaling ...
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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
... MEK inhibitors differ from most other kinase inhibitors as they do not compete with ATP binding (non-ATP competitive), which confers a high specificity [75]. Most MEK inhibitors are specific and do not inhibit many ...
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Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype
... activating Ras mutations by sequenc- ing codons 3–99 of H-Ras, 1–98 of N-Ras, and 1–94 of K- ...the mutations most commonly associated with oncogenic Ras ...found ...
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Mutations in the K ras oncogene induced by 1,2 dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa
... point mutations activating K-ras or H-ras oncogenes, induced by the procarcinogen 1,2-dimethylhydrazine (DMH), were detectable in preneoplastic or neoplastic rat colonic ...carcinomas. Ras ...
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umi-unc-2281.pdf
... EGFR mutations in the majority of responders, thus identifying a molecular marker with a high predictive value of response (Lynch et ...K-Ras mutations are resistant to EGFR inhibition in both single ...
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WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
... identified RAS- binding protein that mediates RAS degradation [19], in the suppression of CRC, especially that related with the K-RAS mutation-induced activation of ...of RAS, thus restricting ...
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Original Article The mutations of K-ras and BRAF gene in colorectal carcinoma and its clinical significance
... detect mutations in the K-ras (codons 12, 13 and 61) and BRAF genes (codon ...gene mutations and clinical pathological parameters. Results: K-ras mutations were found in 75 cases, and ...
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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
... Specific inhibitors of MEK have been developed (e.g., PD98059 (Pfizer), U0126 (DuPont), PD184352 [CI-1040] (Pfizer), PD0325901 (Pfizer), Selumetinib (a.k.a., ARRY-142886, AZD6244) (Astra-Zeneca), and RDEA119 (Ardea ...
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Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes.
... K-ras mutations in mCRC has also been described according to the geographic area of residence, with a higher prevalence found in western Europe compared to areas outside Europe (Van Cutsem et ...
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Original Article Putative Precursor Cancer Cells in Human Colorectal Cancer Tissue
... the mutations found in the major population, which are likely to be precursors of the major population, and named them precursor cancer ...carcinogenic mutations was well established in the context of tumor ...
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Targeting Autophagy Addiction in Cancer
... K-Ras mutations, we noted that all human-derived PDAC cell lines examined showed elevated basal ...oncogenic Ras- induced transformation and autophagy, further building the case for targeting ...
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A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting KRAS mutations in non small cell lung carcinomas
... Recent studies have shown that some anticancer drugs are only effective against tumors in which the KRAS signaling pathway has not undergone oncogenic activation. These include the small-molecule epidermal growth factor ...
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H-Ras and Its Oncogenic Mutants Ras G12V and Ras Q61L
... The side chains of residues Lysine 147, Leucine 120, Aspartic acid 30, and Tyrosine 32 show conformational shifts due to the presence of glycerol molecules (average R.M.S.D. for these four residues 0.22Å versus overall ...
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