Ras-Protein
Cytotoxic T lymphocyte responses to Ras protein
... p21 Ras which is identical in all three members of the Ras family of proteins in this region ...p21 Ras with an activating substitution at position 12 were immunogenic ...p21 Ras ...
217
Application of the Multiple Solvent Crystal Structures Method to Analyze the Protein Binding Surface of H-Ras Protein
... examine protein structural changes at the ...cyclic protein side ...hydrophobic protein pocket (Wilkemeyer, Menkari, et ...a protein stabilizing agent in ...
195
Photoaffinity labeling with GTP of viral p21 ras protein expressed in Escherichia coli.
... Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viru[r] ...
9
WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
... identified RAS- binding protein that mediates RAS degradation [19], in the suppression of CRC, especially that related with the K-RAS mutation-induced activation of ...of RAS, thus ...
13
Impact of Mutations on K Ras p120GAP Interaction
... The Ras proteins, H-, N- and K-Ras, are low molecular weight GTPases that play important roles in signal transduction of cell proliferation and/or differentiation ...state, Ras binds guanosine ...
9
Thesis
... of Ras codon bias. We have created transgenic versions of fly Ras that are 100% identical in amino acid sequence, but vary greatly with regards to their codons ...mammalian RAS through work done by ...
23
Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies
... of Ras protein pairs that are similar in sequence but separated from each other in the interactome (Panel III in Figure 4) contrasts with the abundance of highly divergent Ras pairs close in the ...
17
Cellular responses to oncogenic Ras signalling
... human Ras proto-oncogenes encode for four highly homologous protein isoforms, H-, K(A)-, K(B)- and N-Ras, that function as molecular switches and timers to transduce signals from activated cell ...
206
KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer
... and Ras-ERK pathways closely interact during tumorigenesis although the mechanism is poorly understood ...K-Ras protein (MT-K-Ras) in CRC cells harboring both APC and K-Ras mutations ...
14
A mouse model for Costello syndrome reveals an Ang II–mediated hypertensive condition
... Protein extracts (40 μg) from the indicated genotypes obtained from 2-month-old adult brains and E14.5 whole embryos were resolved by SDS-PAGE, transferred to a nitrocellulose mem- brane, and blotted with ...
12
The Role of Tyrosine Phosphorylation in Regulation of Signal Transduction Pathways in Unicellular Eukaryotes
... microbial ras genes to be described were those from the budding yeast Saccharomyces ...two ras genes, ras1 and ras2, that encode proteins with nearly 90% homology to the first 80 positions of the mammalian ...
24
Dysregulation of protein trafficking in neurodegeneration
... of protein trafficking in the context of neurodegenerative diseases is far from ...in protein sorting and neuropathology found in DS and AD so far, further studies are anticipated to uncover unique ...
9
Regulation of the mitogen activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts
... atypical protein kinase C (PKC) isoform PKC (Mizukami et ...mitogen-activated protein kinase- activated protein kinase 2 (MAPKAP K-2) downstream of p38 MAPK (Bogoyevitch et ...
12
The regulation of TGFβ signal transduction
... Upon binding to DNA and to their transcriptional partners, Smads recruit co-activators and histone acetyltransferases, such as p300, C/EBP-binding protein (CBP) and p300/CBP-associated factor (P/CAF), facilitating ...
16
H-Ras and Its Oncogenic Mutants Ras G12V and Ras Q61L
... The plasmid was then placed into the XL-Blue cells via the transformation protocol supplied by the Quick Change II Site-Directed Mutagenesis Kit. The cells were selectively grown on Lauria broth agar plates with ...
42
Original Article Effect of Ras homolog C gene silencing on the expression of oesophageal cancer-associated Ras homolog C and vascular endothelial growth factor
... In this study, RT-PCR, in situ hybridization and immunohistochemistry techniques were first combined to apply in the detection of RhoC mRNA and protein expression in the nude mice of each group. Results showed ...
11
Original Article Panax notoginseng saponins improves the malignancy of chronic myeloid leukemia by inducing cell apoptosis and autophagy
... matopoietic stem cells which is induced by the oncogenic Bcr-Abl tyrosine kinase [20]. In recent years, the application of tyrosine kinase inhibitors in CML treatment has been greatly improved [21, 22]. However, due to ...
8
The Novel Plant Homeodomain Protein Rhinoceros Antagonizes Ras Signaling in the Drosophila Eye
... (EGFR)/Ras/mitogen-activated protein kinase sitions and differentiate (reviewed in McConnell ...the Ras pathway) As development progresses, later-born neurons must is necessary for the specification ...
14
Ras dva, a member of novel family of small GTPases, is required for the anterior ectoderm patterning in the Xenopus laevis embryo
... on, Ras-dva expression is inhibited in the anterior neural plate by another homeodomain factor ...of Ras-dva functioning by the dominant-negative mutant or by the antisense morpholino oligonucleotides ...
10
Meta analysis of SUMO1
... While co-expression meta-analysis data has previously been shown to have a high correlation with known path- ways in other studies [2,3], prudence should still be used when interpreting novel findings until they can be ...
5